Zobrazeno 1 - 10
of 492
pro vyhledávání: '"TRPC4"'
Autor:
Xingjuan Chen, Yunzheng Yan, Zhiqiang Liu, Shaokang Yang, Wei Li, Zhuang Wang, Mengyuan Wang, Juan Guo, Zhenyang Li, Weiyan Zhu, Jingjing Yang, Jiye Yin, Qingsong Dai, Yuexiang Li, Cui Wang, Lei Zhao, Xiaotong Yang, Xiaojia Guo, Ling Leng, Jiaxi Xu, Alexander G Obukhov, Ruiyuan Cao, Wu Zhong
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 8, Pp 1817-1839 (2024)
Abstract Zika virus (ZIKV) infection may lead to severe neurological consequences, including seizures, and early infancy death. However, the involved mechanisms are still largely unknown. TRPC channels play an important role in regulating nervous sys
Externí odkaz:
https://doaj.org/article/f40606a0be644b1b80177e9be7140294
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
GPCR-Gi protein pathways are involved in the regulation of vagus muscarinic pathway under physiological conditions and are closely associated with the regulation of internal visceral organs. The muscarinic receptor-operated cationic channel is import
Externí odkaz:
https://doaj.org/article/8b43921b1c9342f697c3ec712f91337d
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115672- (2023)
In intestinal smooth muscle cells, receptor-operated TRPC4 are responsible for the majority of muscarinic receptor cation current (mICAT), which initiates cholinergic excitation-contraction coupling. Our aim was to examine the effects of the TRPC4 in
Externí odkaz:
https://doaj.org/article/96d674eac48e42afbf777a4d68942345
Autor:
Vijay Gupta, Afif Ben-Mahmoud, Bonsu Ku, Dinesh Velayutham, Zainab Jan, Abdi Yousef Aden, Ahmad Kubbar, Fouad Alshaban, Lawrence W. Stanton, Puthen Veettil Jithesh, Lawrence C. Layman, Hyung-Goo Kim
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
This study investigated the genetic underpinnings of autism spectrum disorder (ASD) in a Middle Eastern cohort in Qatar using exome sequencing. The study identified six candidate autism genes in independent simplex families, including both four known
Externí odkaz:
https://doaj.org/article/c16ac00a1bcd4c16a7757d6b44f8f09c
Akademický článek
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Autor:
Mizael C. Araújo, Suzany H. S. Soczek, Jaqueline P. Pontes, Bruno A. S. Pinto, Lucas M. França, Bruna da Silva Soley, Gabriela S. Santos, Warlison F. de Silva Saminez, Fernanda K. M. Fernandes, João L. do Carmo Lima, Daniele Maria-Ferreira, João F. S. Rodrigues, Nara L. M. Quintão, Valério Monteiro-Neto, Antônio M. A. Paes, Elizabeth S. Fernandes
Publikováno v:
Pharmaceuticals, Vol 16, Iss 8, p 1100 (2023)
Sugar-induced metabolic imbalances are a major health problem since an excessive consumption of saccharides has been linked to greater obesity rates at a global level. Sucrose, a disaccharide composed of 50% glucose and 50% fructose, is commonly used
Externí odkaz:
https://doaj.org/article/0d17aba08b35470ca8c4c0dfbdab2808
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Ethanolamine-containing alkenyl ether glycerophospholipids, plasmalogens, are major cell membrane components of mammalian cells that activate membrane protein receptors such as ion transporters and G-protein coupled receptors. However, the mechanism
Externí odkaz:
https://doaj.org/article/adcc572234f9468c9c93469fe8923ff3
Akademický článek
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Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 7897 (2023)
Migraine is a neurovascular disorder that affects approximately 12% of the global population. While its exact causes are still being studied, researchers believe that nociceptive neurons in the trigeminal ganglia play a key role in the pain signals o
Externí odkaz:
https://doaj.org/article/8ce6d0199eb849ada67cc198959faf91
Autor:
Babak Saber Marouf, Antonio Reboreda, Frederik Theissen, Rahul Kaushik, Magdalena Sauvage, Alexander Dityatev, Motoharu Yoshida
Publikováno v:
Biology, Vol 12, Iss 4, p 629 (2023)
Hippocampal local field potentials (LFP) are highly related to behavior and memory functions. It has been shown that beta band LFP oscillations are correlated with contextual novelty and mnemonic performance. Evidence suggests that changes in neuromo
Externí odkaz:
https://doaj.org/article/d60927e8ef414b07a4e688b2fb319205