Zobrazeno 1 - 10 of 824 pro vyhledávání: '"TROUGH LEVELS"'
1
Akademický článek
Studying the association between single nucleotide polymorphisms of metabolizing enzymes and the therapeutic serum levels of calcineurin inhibitors in Egyptian liver transplant patients
Autor: Nermeen N. Abuelsoud, Mohamed Bahaa, Sara A. Osman, Nouran Younis, Mohamed M. Kamal
Publikováno v: Future Journal of Pharmaceutical Sciences, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Background Many clinical variables might impact the pharmacokinetics of calcineurin inhibitors (CIs). Different alleles of cytochromes P450 (CYP)3A4/5 and drug transporter P-glycoprotein are the main variables. Other variables include reloca
Externí odkaz: https://doaj.org/article/06cde680358d425e9927969eaeb0a782
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2
Akademický článek
Effect of low vs. high vancomycin trough level on the clinical outcomes of adult patients with sepsis or gram-positive bacterial infections: a systematic review and meta-analysis
Autor: Subhash Chander, Roopa Kumari, Hong Yu Wang, Yaqub Nadeem Mohammed, Om Parkash, Sindhu Lohana, FNU Sorath, Abhi Chand Lohana, FNU Sadarat, Sheena Shiwlani
Publikováno v: BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background & objective The Infectious Disease Society of America guidelines recommend vancomycin trough levels of 15–20 mg/L for severe methicillin-resistant Staphylococcus aureus. However, recent consensus guidelines of four infectious di
Externí odkaz: https://doaj.org/article/463fe5e627f54e8bac22fd285bb2441c
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3
Akademický článek
Impact of Vancomycin trough levels monitoring on uncomplicated methilcillin-resistant Staphylococcus aureus bacteremia in chronic kidney disease on hemodialysis, retrospective cohort
Autor: Julian Felipe Ramirez-Osorio, Juan Esteban Velez-Hernandez, Nathalia Fernandez-Castaño, David Felipe Rojas-Hernandez, Fabian Jaimes
Publikováno v: BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background CKD patients on hemodialysis (HD) with Staphylococcus aureus (SA) bacteremia present high morbidity, mortality and increased risk of MRSA. Vancomycin is the antibiotic of choice in these cases, it has a narrow therapeutic margin a
Externí odkaz: https://doaj.org/article/439f6d446d2c4a4e887070145ce33e7b
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4
Akademický článek
Early CYP3A5 Genotype-Based Adjustment of Tacrolimus Dosage Reduces Risk of De Novo Donor-Specific HLA Antibodies and Rejection among CYP3A5-Expressing Renal Transplant Patients
Autor: Kristina Schönfelder, Birte Möhlendick, Ute Eisenberger, Andreas Kribben, Winfried Siffert, Falko M. Heinemann, Anja Gäckler, Benjamin Wilde, Justa Friebus-Kardash
Publikováno v: Diagnostics, Vol 14, Iss 19, p 2202 (2024)
Background/Objectives: Our previous retrospective single-center cohort study found, at 3-year follow-up, a trend toward low tacrolimus trough levels and an increased risk of de novo donor-specific anti-HLA antibodies (DSAs) and of antibody-mediated r
Externí odkaz: https://doaj.org/article/d93c3686f4fa4a33a24cacdf6a79f72e
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5
Akademický článek
Defining a therapeutic range for adalimumab serum concentrations in the management of pediatric noninfectious uveitis, a step towards personalized treatment
Autor: Jo L. Dehoorne, Helena Groth, Emma Carlé, Ilse De Schrijver, Celine Sys, Patricia Delbeke, Elke O. Kreps, Thomas Renson, Carolien Bonroy
Publikováno v: Pediatric Rheumatology Online Journal, Vol 21, Iss 1, Pp 1-11 (2023)
Abstract Background Adalimumab is currently considered the most efficacious anti-TNFα agent for childhood noninfectious uveitis (NIU). The objective of this study was to define a therapeutic range for adalimumab trough levels in the treatment of chi
Externí odkaz: https://doaj.org/article/a36938333bc7459b99d2d5631678c5ed
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6
Akademický článek
High BMI is associated with lower TNF-α inhibitor serum trough levels and higher disease activity in patients with axial spondyloarthritis
Autor: Liseth de Wolff, Suzanne Arends, Elisabeth Brouwer, Hendrika Bootsma, Anneke Spoorenberg
Publikováno v: Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-9 (2023)
Abstract Background TNF-α inhibitor (TNFi) serum trough levels have previously been found to be related to disease activity in axial spondyloarthritis (axSpA). However, most research regarding serum trough levels has been conducted in patients who o
Externí odkaz: https://doaj.org/article/a27c28729cba422a91c4cdc39990477a
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7
Akademický článek
Tacrolimus monitoring in hair samples of kidney transplant recipients
Autor: Alexander Born, Federica Bocchi, Christian Kuhn, Ursula Amstutz, Markus R. Baumgartner, Daniel Sidler
Publikováno v: Frontiers in Medicine, Vol 10 (2023)
BackgroundCalcineurin inhibitors, including tacrolimus, remain a cornerstone of immunosuppressive therapy after kidney transplantation. However, the therapeutic window is narrow, and nephrotoxic side effects occur with overdose, while the risk of all
Externí odkaz: https://doaj.org/article/eee74dc453574e5f9c0f3e80abd6cafe
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9
Akademický článek
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10
Akademický článek
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Plný text Recenzováno Digitální knihovna AV ČR
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