Zobrazeno 1 - 10
of 1 570
pro vyhledávání: '"TRNA modification"'
Autor:
Yumika Sato, Ayako Takita, Kazutomo Suzue, Yusuke Hashimoto, Suguru Hiramoto, Masami Murakami, Haruyoshi Tomita, Hidetada Hirakawa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract tRNA modifications play a crucial role in ensuring accurate codon recognition and optimizing translation levels. While the significance of these modifications in eukaryotic cells for maintaining cellular homeostasis and physiological functio
Externí odkaz:
https://doaj.org/article/35696eeba1484b0ba31ef3299773b31e
Autor:
Paolo Olivieri, Arkadiuz Zupok, Tugba Yildiz, Jonathan Oltmanns, Angelika Lehmann, Ewelina Sokolowska, Aleksandra Skirycz, Volker Schünemann, Silke Leimkühler
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT All sulfur transfer pathways have generally a l-cysteine desulfurase as an initial sulfur-mobilizing enzyme in common, which serves as a sulfur donor for the biosynthesis of numerous sulfur-containing biomolecules in the cell. In Escherichia
Externí odkaz:
https://doaj.org/article/1c0f1b057c07423385460977d3c5e140
Autor:
Pan Zhao, Lin Xia, Dan Chen, Wei Xu, Huanping Guo, Yinying Xu, Bingbing Yan, Xiao Wu, Yuxia Li, Yunfang Zhang, Xi Zhang
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-17 (2024)
Abstract Background RNA modifications have been proven to play fundamental roles in regulating cellular biology process. Recently, maladjusted N7-methylguanosine (m7G) modification and its modifiers METTL1/WDR4 have been confirmed an oncogene role in
Externí odkaz:
https://doaj.org/article/c51804a50f0749e4b7d115ad558bdb4e
Autor:
Bettina Böttcher, Sandra D. Kienast, Johannes Leufken, Cristian Eggers, Puneet Sharma, Christine M. Leufken, Bianka Morgner, Hannes C. A. Drexler, Daniela Schulz, Stefanie Allert, Ilse D. Jacobsen, Slavena Vylkova, Sebastian A. Leidel, Sascha Brunke
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 5 (2024)
ABSTRACTtRNA modifications play important roles in maintaining translation accuracy in all domains of life. Disruptions in the tRNA modification machinery, especially of the anticodon stem loop, can be lethal for many bacteria and lead to a broad ran
Externí odkaz:
https://doaj.org/article/a114f64854bb4cc889551a3b09495768
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
The in vivo codon decoding preferences of tRNAs with an authentic adenosine residue at position 34 of the anticodon, the wobble position, are largely unexplored because very few unmodified A34 tRNA genes exist across the three domains of life. The ex
Externí odkaz:
https://doaj.org/article/6e99ee11419e4d288f4d7cde473ebd68
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7889 (2024)
The OSGEP gene encodes O-sialoglycoprotein endopeptidase, a catalytic unit of the highly conserved KEOPS complex (Kinase, Endopeptidase, and Other Proteins of small Size) that regulates the second biosynthetic step in the formation of N-6-threonylcar
Externí odkaz:
https://doaj.org/article/bac2be7ab33c4222b8be99a9fcbe4df0
Autor:
Samia Quaiyum, Jingjing Sun, Virginie Marchand, Guangxin Sun, Colbie J. Reed, Yuri Motorin, Peter C. Dedon, Michael F. Minnick, Valérie de Crécy-Lagard
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Transfer RNA (tRNA) modifications play a crucial role in maintaining translational fidelity and efficiency, and they may function as regulatory elements in stress response and virulence. Despite their pivotal roles, a comprehensive mapping of tRNA mo
Externí odkaz:
https://doaj.org/article/2b175cc03c7547cbb00c234e3ce585c6
Autor:
Huipeng Yao, Tingting Li, Zheng Ma, Xiyuan Wang, Lixiao Xu, Yuxin Zhang, Yi Cai, Zizhong Tang
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Rhodophyta are among the closest known relatives of green plants. Studying the codons of their genomes can help us understand the codon usage pattern and characteristics of the ancestor of green plants. By studying the codon usage pattern of
Externí odkaz:
https://doaj.org/article/d0f7e17e360d48cc926965a9f99cd474
Autor:
Jenna C. McGuffey, Clay D. Jackson-Litteken, Gisela Di Venanzio, Aubree A. Zimmer, Jessica M. Lewis, Jesus S. Distel, Kyusik Q. Kim, Hani S. Zaher, Juan Alfonzo, Nichollas E. Scott, Mario F. Feldman
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Successful pathogens must be able to adapt to a multitude of stressors imposed by their host. Acinetobacter baumannii has emerged as a major global health threat due to its exceptional ability to adapt to hostile environments and skyrocketin
Externí odkaz:
https://doaj.org/article/36fb02e91a4f408baf97b05f436e762d
Autor:
Meike Arend, Koray Ütkür, Harmen Hawer, Klaus Mayer, Namit Ranjan, Lorenz Adrian, Ulrich Brinkmann, Raffael Schaffrath
Publikováno v:
Microbial Cell, Vol 10, Iss 9, Pp 195-203 (2022)
In yeast, Elongator-dependent tRNA modifications are regulated by the Kti11•Kti13 dimer and hijacked for cell killing by zymocin, a tRNase ribotoxin. Kti11 (alias Dph3) also controls modification of elongation factor 2 (EF2) with diphthamide, the t
Externí odkaz:
https://doaj.org/article/cbab6fc1de5a40b2b53aba41197cf186