tRNA modification enzyme-dependent redox homeostasis regulates synapse formation and memory.

Autor: Madhwani KR; Neuroscience Graduate Program, Brown University, Providence, RI 02912., Sayied S; Department of Neuroscience, Brown University, Providence, RI 02912., Ogata CH; Department of Biology, Brown University, Providence, RI 02912., Hogan CA; Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706., Lentini JM; Department of Biology, Center for RNA Biology, University of Rochester, Rochester, NY 14627., Mallik M; Molecular Neurobiology Laboratory, Donders Institute for Brain, Cognition, and Behaviour, Radboud University, Nijmegen 6525 AJ, The Netherlands., Dumouchel JL; Therapeutic Sciences Graduate Program, Brown University, Providence, RI 02912., Storkebaum E; Molecular Neurobiology Laboratory, Donders Institute for Brain, Cognition, and Behaviour, Radboud University, Nijmegen 6525 AJ, The Netherlands., Fu D; Department of Biology, Center for RNA Biology, University of Rochester, Rochester, NY 14627., O'Connor-Giles KM; Department of Neuroscience, Brown University, Providence, RI 02912.; Carney Institute for Brain Sciences, Brown University, Providence, RI 02912.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Nov 12; Vol. 121 (46), pp. e2317864121. Date of Electronic Publication: 2024 Nov 04.

Insight into ALKBH8-related intellectual developmental disability based on the first pathogenic missense variant.

Autor: Maddirevula S; Department of Translational Genomics, Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, 11211, Saudi Arabia., Alameer S; Department of Pediatrics, Ministry of the National Guard-Health Affairs, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia., Ewida N; Department of Translational Genomics, Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, 11211, Saudi Arabia., de Sousa MML; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7491, Trondheim, Norway., Bjørås M; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7491, Trondheim, Norway., Vågbø CB; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7491, Trondheim, Norway.; Proteomics and Modomics Experimental Core and St. Olavs Hospital Central Staff, Trondheim, Norway., Alkuraya FS; Department of Translational Genomics, Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, 11211, Saudi Arabia. FAlKuraya@kfshrc.edu.sa.; Department of Anatomy and Cell Biology, College of Medicine, Alfaisal University, Riyadh, 11533, Saudi Arabia. FAlKuraya@kfshrc.edu.sa.

Publikováno v: Human genetics [Hum Genet] 2022 Feb; Vol. 141 (2), pp. 209-215. Date of Electronic Publication: 2021 Nov 10.

The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene.

Autor: Leonardi A; Department of Nanoscale Science and Engineering, University at Albany , Albany, NY, USA., Kovalchuk N; College of Pharmacy, Department of Toxicology and Pharmacology, University of Arizona , Tucson, AZ, USA., Yin L; College of Pharmacy, Department of Toxicology and Pharmacology, University of Arizona , Tucson, AZ, USA., Endres L; College of Arts and Sciences, SUNY Polytechnic Institute , Utica, NY, USA.; The RNA Institute, University at Albany , Albany, NY, USA., Evke S; Nanoscale Science Constellation, SUNY Polytechnic Institute , Albany, NY, USA., Nevins S; Nanoscale Science Constellation, SUNY Polytechnic Institute , Albany, NY, USA., Martin S; Department of Biological Sciences, University at Albany , Albany, NY, USA., Dedon PC; Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge, MA, USA.; Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology , Singapore., Melendez JA; The RNA Institute, University at Albany , Albany, NY, USA.; Nanoscale Science Constellation, SUNY Polytechnic Institute , Albany, NY, USA., Van Winkle L; Center for Health and the Environment, University of California Davis , Davis, CA, USA., Zhang QY; College of Pharmacy, Department of Toxicology and Pharmacology, University of Arizona , Tucson, AZ, USA., Ding X; College of Pharmacy, Department of Toxicology and Pharmacology, University of Arizona , Tucson, AZ, USA., Begley TJ; The RNA Institute, University at Albany , Albany, NY, USA.; Department of Biological Sciences, University at Albany , Albany, NY, USA.

Publikováno v: Epigenetics [Epigenetics] 2020 Oct; Vol. 15 (10), pp. 1121-1138. Date of Electronic Publication: 2020 Apr 17.

Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes.

Autor: Aherrahrou R; Center for Public Health Genomics, University of Virginia, Charlottesville (R.A., R.N.P., Y.T.A., M.D.K., J.Y.S., D.W., J.H., G.M.S., C.L.M., M.C.)., Lue D; Department of Biomedical Engineering, University of Virginia, Charlottesville (D.L., R.N.P., Y.T.A., J.Y.S., M.C.)., Perry RN; Center for Public Health Genomics, University of Virginia, Charlottesville (R.A., R.N.P., Y.T.A., M.D.K., J.Y.S., D.W., J.H., G.M.S., C.L.M., M.C.).; Department of Biomedical Engineering, University of Virginia, Charlottesville (D.L., R.N.P., Y.T.A., J.Y.S., M.C.)., Aberra YT; Center for Public Health Genomics, University of Virginia, Charlottesville (R.A., R.N.P., Y.T.A., M.D.K., J.Y.S., D.W., J.H., G.M.S., C.L.M., M.C.).; Department of Biomedical Engineering, University of Virginia, Charlottesville (D.L., R.N.P., Y.T.A., J.Y.S., M.C.)., Khan MD; Center for Public Health Genomics, University of Virginia, Charlottesville (R.A., R.N.P., Y.T.A., M.D.K., J.Y.S., D.W., J.H., G.M.S., C.L.M., M.C.)., Soh JY; Center for Public Health Genomics, University of Virginia, Charlottesville (R.A., R.N.P., Y.T.A., M.D.K., J.Y.S., D.W., J.H., G.M.S., C.L.M., M.C.).; Department of Biomedical Engineering, University of Virginia, Charlottesville (D.L., R.N.P., Y.T.A., J.Y.S., M.C.)., Örd T; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.Ö., P.S., Q.Y., H.G., M.U.K.)., Singha P; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.Ö., P.S., Q.Y., H.G., M.U.K.)., Yang Q; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.Ö., P.S., Q.Y., H.G., M.U.K.)., Gilani H; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.Ö., P.S., Q.Y., H.G., M.U.K.)., Benavente ED; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, The Netherlands (E.D.B., H.M.d.R.)., Wong D; Center for Public Health Genomics, University of Virginia, Charlottesville (R.A., R.N.P., Y.T.A., M.D.K., J.Y.S., D.W., J.H., G.M.S., C.L.M., M.C.)., Hinkle J; Center for Public Health Genomics, University of Virginia, Charlottesville (R.A., R.N.P., Y.T.A., M.D.K., J.Y.S., D.W., J.H., G.M.S., C.L.M., M.C.)., Ma L; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, NY (L.M., J.L.M.B.).; Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, NY (L.M., J.L.M.B.)., Sheynkman GM; Center for Public Health Genomics, University of Virginia, Charlottesville (R.A., R.N.P., Y.T.A., M.D.K., J.Y.S., D.W., J.H., G.M.S., C.L.M., M.C.).; Cancer Center, University of Virginia, Charlottesville (G.M.S.).; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville (G.M.S.)., den Ruijter HM; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, The Netherlands (E.D.B., H.M.d.R.)., Miller CL; Center for Public Health Genomics, University of Virginia, Charlottesville (R.A., R.N.P., Y.T.A., M.D.K., J.Y.S., D.W., J.H., G.M.S., C.L.M., M.C.)., Björkegren JLM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, NY (L.M., J.L.M.B.).; Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, NY (L.M., J.L.M.B.).; Integrated Cardio Metabolic Centre, Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden (J.L.M.B.)., Kaikkonen MU; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.Ö., P.S., Q.Y., H.G., M.U.K.)., Civelek M; Center for Public Health Genomics, University of Virginia, Charlottesville (R.A., R.N.P., Y.T.A., M.D.K., J.Y.S., D.W., J.H., G.M.S., C.L.M., M.C.).; Department of Biomedical Engineering, University of Virginia, Charlottesville (D.L., R.N.P., Y.T.A., J.Y.S., M.C.).

Publikováno v: Circulation research [Circ Res] 2023 Feb 03; Vol. 132 (3), pp. 323-338. Date of Electronic Publication: 2023 Jan 04.

Selenoproteins and the senescence-associated epitranscriptome.

Autor: Lee MY; College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA.; The RNA Institute, University at Albany, Albany, NY 12222, USA., Ojeda-Britez S; College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA., Ehrbar D; The RNA Institute, University at Albany, Albany, NY 12222, USA.; Department of Biological Sciences, University at Albany, Albany, NY 12222, USA.; RNA Epitranscriptomics and Proteomics Resource, University at Albany, Albany, NY 12222, USA., Samwer A; Munich International School, Starnberg 82319, Germany., Begley TJ; The RNA Institute, University at Albany, Albany, NY 12222, USA.; Department of Biological Sciences, University at Albany, Albany, NY 12222, USA.; RNA Epitranscriptomics and Proteomics Resource, University at Albany, Albany, NY 12222, USA., Melendez JA; College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA.; The RNA Institute, University at Albany, Albany, NY 12222, USA.

Publikováno v: Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2022 Dec; Vol. 247 (23), pp. 2090-2102. Date of Electronic Publication: 2022 Aug 29.