Novel CAR-T cells targeting TRKB for the treatment of solid cancer.

Autor: Liang D; Department of Targeting Therapy & Immunology and Laboratory of Animal Tumor Models, Cancer Center and State Key Laboratory of Respiratory Health and Multimorbidity and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Tang J; Department of Targeting Therapy & Immunology and Laboratory of Animal Tumor Models, Cancer Center and State Key Laboratory of Respiratory Health and Multimorbidity and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Sun B; Department of Targeting Therapy & Immunology and Laboratory of Animal Tumor Models, Cancer Center and State Key Laboratory of Respiratory Health and Multimorbidity and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China., He S; Department of Targeting Therapy & Immunology and Laboratory of Animal Tumor Models, Cancer Center and State Key Laboratory of Respiratory Health and Multimorbidity and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Yang D; Department of Targeting Therapy & Immunology and Laboratory of Animal Tumor Models, Cancer Center and State Key Laboratory of Respiratory Health and Multimorbidity and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Ma H; Department of Targeting Therapy & Immunology and Laboratory of Animal Tumor Models, Cancer Center and State Key Laboratory of Respiratory Health and Multimorbidity and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Yun Y; Department of Targeting Therapy & Immunology and Laboratory of Animal Tumor Models, Cancer Center and State Key Laboratory of Respiratory Health and Multimorbidity and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Zhu Y; Department of Targeting Therapy & Immunology and Laboratory of Animal Tumor Models, Cancer Center and State Key Laboratory of Respiratory Health and Multimorbidity and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Wei W; Department of Targeting Therapy & Immunology and Laboratory of Animal Tumor Models, Cancer Center and State Key Laboratory of Respiratory Health and Multimorbidity and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Chen H; Laboratory of Metabolism and Aging Research, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China. chenhy82@scu.edu.cn., Zhao X; Department of Targeting Therapy & Immunology and Laboratory of Animal Tumor Models, Cancer Center and State Key Laboratory of Respiratory Health and Multimorbidity and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. zhaoxudong@wchscu.cn.

Publikováno v: Apoptosis : an international journal on programmed cell death [Apoptosis] 2024 Dec; Vol. 29 (11-12), pp. 2183-2196. Date of Electronic Publication: 2024 Mar 18.

Exercise-conditioned plasma ameliorates postoperative cognitive dysfunction by activating hippocampal cholinergic circuit and enhancing BDNF/TrkB signaling.

Autor: Lu, Xiaodi¹ (AUTHOR), Xiong, Weijie² (AUTHOR), Chen, Zhuo¹ (AUTHOR), Li, Yurou² (AUTHOR), Xu, Fengyan² (AUTHOR), Yang, Xue² (AUTHOR), Long, Meiwen² (AUTHOR), Guo, Wenhan² (AUTHOR), Wu, Shuliang² (AUTHOR) wushuliang@ems.hrbmu.edu.cn, Sun, Liang² (AUTHOR) sunliang@hrbmu.edu.cn, Wang, Guonian³ (AUTHOR) wangguonian609cn@aliyun.com

Publikováno v: Cell Communication & Signaling. 11/18/2024, Vol. 22 Issue 1, p1-30. 30p.

Activation of BDNF-TrkB Signaling in Specific Structures of the Sheep Brain by Kynurenic Acid.

Autor: Roszkowicz-Ostrowska K; The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Str., 05-110 Jabłonna, Poland., Młotkowska P; The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Str., 05-110 Jabłonna, Poland., Marciniak E; The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Str., 05-110 Jabłonna, Poland., Szlis M; The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Str., 05-110 Jabłonna, Poland., Barszcz M; The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Str., 05-110 Jabłonna, Poland., Misztal T; The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Str., 05-110 Jabłonna, Poland.

Publikováno v: Cells [Cells] 2024 Nov 21; Vol. 13 (23). Date of Electronic Publication: 2024 Nov 21.

Inhibition of TrkB kinase activity impairs autophagy in cervical motor neurons of young but not old mice.

Autor: Pareja-Cajiao M; Department of Anesthesiology & Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA., Gransee HM; Department of Anesthesiology & Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA., Jahanian S; Department of Anesthesiology & Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA., Sieck GC; Department of Anesthesiology & Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Physiology & Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA., Mantilla CB; Department of Anesthesiology & Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Physiology & Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.

Publikováno v: Experimental physiology [Exp Physiol] 2025 Jan; Vol. 110 (1), pp. 166-178. Date of Electronic Publication: 2024 Nov 22.

Flavonoid chrysin activates both TrkB and FGFR1 receptors while upregulates their endogenous ligands such as brain derived neurotrophic factor to promote human neurogenesis.

Autor: Dong X; School of Life Science and Technology, Shanghai Tech University, Shanghai, China.; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China., Pei G; School of Life Science and Technology, Shanghai Tech University, Shanghai, China.; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-Based Biomedicine, The Collaborative Innovation Center for Brain Science, School of Life Sciences and Technology, Tongji University, Shanghai, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China., Yang Z; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China., Huang S; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.

Publikováno v: Cell proliferation [Cell Prolif] 2025 Jan; Vol. 58 (1), pp. e13732. Date of Electronic Publication: 2024 Sep 27.