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Trim71/lin-41 Links an Ancient miRNA Pathway to Human Congenital Hydrocephalus

Autor: Charuta G. Furey, Kristopher T. Kahle, Phan Q. Duy

Publikováno v: Trends in molecular medicine. 25(6)

Tripartite motif 71 (Trim71)/lineage defective 41 (lin-41) is the primary target of the ancient lethal 7 (let-7) miRNA that is essential for survival and development across animal phylogeny. Recent work identified Trim71 as a critical regulator of ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e9d12fee007e175be9eb0d04e95f85
https://pubmed.ncbi.nlm.nih.gov/30975633

TRIM71 Deficiency Causes Germ Cell Loss During Mouse Embryogenesis and Is Associated With Human Male Infertility

Autor: Lucia A. Torres-Fernández, Jana Emich, Yasmine Port, Sibylle Mitschka, Marius Wöste, Simon Schneider, Daniela Fietz, Manon S. Oud, Sara Di Persio, Nina Neuhaus, Sabine Kliesch, Michael Hölzel, Hubert Schorle, Corinna Friedrich, Frank Tüttelmann, Waldemar Kolanus

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Mutations affecting the germline can result in infertility or the generation of germ cell tumors (GCT), highlighting the need to identify and characterize the genes controlling germ cell development. The RNA-binding protein and E3 ubiquitin ligase TR

Externí odkaz: https://doaj.org/article/bbb96f35293748e18f3b5a151fccdc44

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The Conundrum of Mechanics Versus Genetics in Congenital Hydrocephalus and Its Implications for Fetal Therapy Approaches: A Scoping Review.

Autor: Herzeg A; Department of Surgery, University of California, San Francisco, San Francisco, California, USA.; UCSF Center for Maternal-Fetal Precision Medicine, University of California San Francisco, San Francisco, California, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, USA.; Department of Obstetrics and Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA., Borges B; Department of Surgery, University of California, San Francisco, San Francisco, California, USA.; UCSF Center for Maternal-Fetal Precision Medicine, University of California San Francisco, San Francisco, California, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, USA., Diafos LN; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, USA.; Department of Pediatrics and Benioff Children's Hospital, University of California, San Francisco, San Francisco, California, USA., Gupta N; UCSF Center for Maternal-Fetal Precision Medicine, University of California San Francisco, San Francisco, California, USA.; Department of Pediatrics and Benioff Children's Hospital, University of California, San Francisco, San Francisco, California, USA.; Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.; Brain Tumor Research Center, University of California, San Francisco, San Francisco, California, USA., MacKenzie TC; Department of Surgery, University of California, San Francisco, San Francisco, California, USA.; UCSF Center for Maternal-Fetal Precision Medicine, University of California San Francisco, San Francisco, California, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, USA.; Department of Obstetrics and Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA.; Department of Pediatrics and Benioff Children's Hospital, University of California, San Francisco, San Francisco, California, USA., Sanders SJ; UCSF Center for Maternal-Fetal Precision Medicine, University of California San Francisco, San Francisco, California, USA.; Department of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.; Institute for Developmental and Regenerative Medicine, Oxford University, Oxford, UK.

Publikováno v: Prenatal diagnosis [Prenat Diagn] 2024 Oct; Vol. 44 (11), pp. 1354-1366. Date of Electronic Publication: 2024 Sep 01.