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pro vyhledávání: '"TREX2"'
Akademický článek
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Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102072- (2023)
Paired SpCas9 nickases (SpCas9n) are an effective strategy to reduce off-target effect in genome editing. However, this approach is not efficient with 3′-overhanging ends, limiting its applications. In order to expand the utility of paired SpCas9n
Externí odkaz:
https://doaj.org/article/8c880b1b54f84caeabaf083b01abb9ed
Autor:
Wang, Yue, Feng, Yi-Li, Liu, Qian, Xiao, Jing-Jing, Liu, Si-Cheng, Huang, Zhi-Cheng, Xie, An-Yong
Publikováno v:
In Molecular Therapy - Nucleic Acids 12 December 2023 34
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113637- (2024)
Summary: TREX2, a 3′-5′ exonuclease, is a part of the DNA damage tolerance (DDT) pathway that stabilizes replication forks (RFs) by ubiquitinating PCNA along with the ubiquitin E3 ligase RAD18 and other DDT factors. Mismatch repair (MMR) corrects
Externí odkaz:
https://doaj.org/article/668be8cc974341a1a9bbc18f90cf34e9
Autor:
Marc Güell
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102119- (2024)
Externí odkaz:
https://doaj.org/article/0b031ccdaeb04f319b060e7e64c23144
Autor:
Ko, Jun Ho, Son, Mi Young, Zhou, Qing, Molnarova, Lucia, Song, Lambert, Mlcouskova, Jarmila, Jekabsons, Atis, Montagna, Cristina, Krejci, Lumir, Hasty, Paul
Publikováno v:
In Cell Reports 22 December 2020 33(12)
Autor:
Hasty, Paul1 hastyhsc@gmail.com
Publikováno v:
Molecular & Cellular Oncology. 2021, Vol. 8 Issue 2, p1-3. 3p.
Autor:
Güell M; Universitat Pompeu Fabra, Barcelona, Spain.; ICREA, Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.
Publikováno v:
Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2024 Jan 19; Vol. 35 (1), pp. 102119. Date of Electronic Publication: 2024 Jan 19 (Print Publication: 2024).
Autor:
Manils, Joan, Casas, Eduard, Viña-Vilaseca, Arnau, López-Cano, Marc, Díez-Villanueva, Anna, Gómez, Diana, Marruecos, Laura, Ferran, Marta, Benito, Carmen, Perrino, Fred W., Vavouri, Tanya, de Anta, Josep Maria, Ciruela, Francisco, Soler, Concepció
Publikováno v:
In Journal of Investigative Dermatology December 2016 136(12):2345-2355
Autor:
Paul Hasty
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 2 (2021)
Three prime Repair Exonuclease 2 (Trex2) alters replication fork (RF) stability and mutation levels in cells defective for homologous recombination (HR). Trex2 has multiple functions that can either cause or supress RF instability in cells with diffe
Externí odkaz:
https://doaj.org/article/a99ddbd2c11a493f94b5935b8d9221b6