Risk assessment of venous thrombosis in families with known hereditary thrombophilia: the MARseilles‐NImes prediction model

Autor: Cohen, W., Castelli, C., Suchon, P., Bouvet, S., Aillaud, M.F., Brunet, D., Barthet, M.C., Alessi, M.C., Trégouët, D.A., Morange, P.E. ^*

Publikováno v: In Journal of Thrombosis and Haemostasis February 2014 12(2):138-146

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Cerebral small vessel disease genomics and its implications across the lifespan

Autor: Sargurupremraj, M., Suzuki, H., Jian, X.Q., Sarnowski, C., Evans, T.E., Bis, J.C., Eiriksdottir, G., Sakaue, S., Terzikhan, N., Habes, M., Zhao, W., Armstrong, N.J., Hofer, E., Yanek, L.R., Hagenaars, S.P., Kumar, R.B., Akker, E.B. van den, McWhirter, R.E., Trompet, S., Mishra, A., Saba, Y., Satizabal, C.L., Beaudet, G., Petit, L., Tsuchida, A., Zago, L., Schilling, S., Sigurdsson, S., Gottesman, R.F., Lewis, C.E., Aggarwal, N.T., Lopez, O.L., Smith, J.A., Hernandez, M.C.V., Grond, J. van der, Wright, M.J., Knol, M.J., Dorr, M., Thomson, R.J., Bordes, C., Grand, Q. le, Duperron, M.G., Smith, A.V., Knopman, D.S., Schreiner, P.J., Evans, D.A., Rotter, J.I., Beiser, A.S., Maniega, S.M., Beekman, M., Trollor, J., Stott, D.J., Vernooij, M.W., Wittfeld, K., Niessen, W.J., Soumare, A., Boerwinkle, E., Sidney, S., Turner, S.T., Davies, G., Thalamuthu, A., Volker, U., Buchem, M.A. van, Bryan, R.N., Dupuis, J., Bastin, M.E., Ames, D., Teumer, A., Amouyel, P., Kwok, J.B., Bulow, R., Deary, I.J., Schofield, P.R., Brodaty, H., Jiang, J.Y., Tabara, Y., Setoh, K., Miyamoto, S., Yoshida, K., Nagata, M., Kamatani, Y., Matsuda, F., Psaty, B.M., Bennett, D.A., Jager, P.L. de, Mosley, T.H., Sachdev, P.S., Schmidt, R., Warren, H.R., Evangelou, E., Tregouet, D.A., Ikram, M.A., Wen, W., DeCarli, C., Srikanth, V.K., Jukema, J.W., Slagboom, E.P., Kardia, S.L.R., Okada, Y., Mazoyer, B., Wardlaw, J.M., Nyquist, P.A., Mather, K.A., Grabe, H.J., Schmidt, H., Duijn, C.M. van, Gudnason, V., Longstreth, W.T., Launer, L.J., Lathrop, M., Seshadri, S., Tzourio, C., Adams, H.H., Matthews, P.M., Fornage, M., Debette, S., Int Network Thrombosis INVENT Cons, Int Headache Genomics Consortium I

Publikováno v: Nature Communications, 11(1). NATURE RESEARCH
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)

White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older indi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::524d593a80669e714de9730254819978
http://hdl.handle.net/20.500.12278/26449

Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism

Autor: Lindstrom, S., Wang, L., Smith, E.N., Gordon, W., Vlieg, A.V., Andrade, M. de, Brody, J.A., Pattee, J.W., Haessler, J., Brumpton, B., Chasman, D.I., Suchon, P., Chen, M.H., Turman, C., Germain, M., Wiggins, K.L., MacDonald, J., Braekkan, S.K., Armasu, S.M., Pankratz, N., Jackson, R.D., Nielsen, J.B., Giulianini, F., Puurunen, M.K., Ibrahim, M., Heckbert, S.R., Damrauer, S.M., Natarajan, P., Klarin, D., Vries, P.S. de, Sabater-Lleal, M., Huffman, J.E., Bammler, T.K., Frazer, K.A., McCauley, B.M., Taylor, K., Pankow, J.S., Reiner, A.P., Gabrielsen, M.E., Deleuze, J.F., O'Donnell, C.J., Kim, J., McKnight, B., Kraft, P., Hansen, J.B., Rosendaal, F.R., Heit, J.A., Psaty, B.M., Tang, W.H., Kooperberg, C., Hveem, K., Ridker, P.M., Morange, P.E., Johnson, A.D., Kabrhel, C., Tregouet, D.A., Smith, N.L., Busenkell, E., Judy, R., Lynch, J., Levin, M., Aragam, J.H.K., Chaffin, M., Haas, M., Assimes, T.L., Huang, J., Lee, K.M., Shao, Q., Huang, Y.F., Sun, Y.V., Vujkovic, M., Saleheen, D., Miller, D.R., Reaven, P., DuVall, S., Boden, W., Pyarajan, S., Henke, P., Gaziano, J.M., Concato, J., Rader, D.J., Cho, K., Chang, K.M., Wilson, P.W.F., Tsao, P.S., Kathiresan, S., Obi, A., Million Veteran Program, CHARGE Hemostasis Working Grp, INVENT Consortium

Publikováno v: Blood
Blood, American Society of Hematology, 2019, 134 (19), pp.1645-1657. ⟨10.1182/blood.2019000435⟩
Blood, 2019, 134 (19), pp.1645-1657. ⟨10.1182/blood.2019000435⟩
Blood, 134(19), 1645-1657. AMER SOC HEMATOLOGY

Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality. To advance our understanding of the biology contributing to VTE, we conducted a genome-wide association study (GWAS) of VTE and a transcriptome-wide association stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e181c9b2a0dfde198d7f744ad77b132
https://doi.org/10.1182/blood.2019000435

Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis

Autor: Mandaviya, P.R., Aissi, D., Dekkers, K.F., Joehanes, R., Kasela, S., Truong, V., Stolk, L., Heemst, D. van, Ikram, M.A., Lindemans, J., Slagboom, P.E., Tregouet, D.A., Uitterlinden, A.G., Wei, C., Wells, P., Gagnon, F., Greevenbroek, M.M.J. van, Heijmans, B.T., Milani, L., Morange, P.E., Meurs, J.B.J. van, Heil, S.G., BIOS Consortium

Publikováno v: Epigenomics
Epigenomics, 2017, 9 (11), pp.1403-1422. ⟨10.2217/epi-2017-0038⟩
Epigenomics, Future Medicine, 2017, 9 (11), pp.1403-1422. ⟨10.2217/epi-2017-0038⟩
Epigenomics, 9(11), 1403-1422. Future Medicine Ltd.
Epigenomics, 9(11), 1403-1422

International audience; Aim: Homocysteine (Hcy) is a sensitive marker of one-carbon metabolism. Higher Hcy levels have been associated with global DNA hypomethylation. We investigated the association between plasma Hcy and epigenome-wide DNA methylat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b19b6964c81bf912455d3f579cb82c
https://hdl.handle.net/1887/115574