Zobrazeno 1 - 10
of 561
pro vyhledávání: '"TRANSGENERATIONAL EPIGENETIC INHERITANCE"'
Autor:
Andy Madrid, Joyce Koueik, Ligia A. Papale, Roy Chebel, Isabelle Renteria, Emily Cannon, Kirk J. Hogan, Reid S. Alisch, Bermans J. Iskandar
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
In mammals, the molecular mechanisms underlying transgenerational inheritance of phenotypic traits in serial generations of progeny after ancestral environmental exposures, without variation in DNA sequence, remain elusive. We’ve recently described
Externí odkaz:
https://doaj.org/article/cff0eaec72b24cc19201473d4aae2412
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
While transgenerational epigenetic inheritance has been extensively documented in plants, nematodes, and fruit flies, its existence in mammals remains controversial. Several factors have contributed to this debate, including the lack of a clear disti
Externí odkaz:
https://doaj.org/article/112751af57224b8ba7a719666fcf5a02
Autor:
Daniel M. Sapozhnikov, Moshe Szyf
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
Transgenerational epigenetic inheritance in mammals remains a controversial phenomenon. A recent study by Takahashi et al. provides evidence for this mode of inheritance in mice by using a CRISPR/Cas9-based epigenetic editing technique to modify DNA
Externí odkaz:
https://doaj.org/article/4d383914f15e48b3a9642ed8b465d9f0
Publikováno v:
eLife, Vol 13 (2024)
Endocrine disrupting chemicals (EDCs) such as bisphenol S (BPS) are xenobiotic compounds that can disrupt endocrine signaling due to steric similarities to endogenous hormones. EDCs have been shown to induce disruptions in normal epigenetic programmi
Externí odkaz:
https://doaj.org/article/a107967b518c48938b0178a04dc584dc
Autor:
Xiaobing Huang, Qunshan Ye, Wenyu Dai, Jingming Zheng, Yimin Li, Cheng Wang, Zhenhuan Luo, Jing Yang, Wenyan Zhuo, Qin-Li Wan
Publikováno v:
Environment International, Vol 191, Iss , Pp 108952- (2024)
Cadmium is a significant environmental pollutant that poses a substantial health hazard to humans due to its propensity to accumulate in the body and resist excretion. We have a comprehensive understanding of the damage caused by Cd exposure and the
Externí odkaz:
https://doaj.org/article/03d74135278447249bc5581e16f30c07
Autor:
Adrian Bird
Publikováno v:
Frontiers in Epigenetics and Epigenomics, Vol 2 (2024)
Transgenerational epigenetic inheritance in humans and other vertebrates has been controversial for over 150 years and remains so. It currently depends on the assumption that the environment is able to influence the genome, in particular by altering
Externí odkaz:
https://doaj.org/article/3381b4c42fcc4871993d09eb33da9ece
Autor:
Antony M Jose
Publikováno v:
eLife, Vol 12 (2024)
Interacting molecules create regulatory architectures that can persist despite turnover of molecules. Although epigenetic changes occur within the context of such architectures, there is limited understanding of how they can influence the heritabilit
Externí odkaz:
https://doaj.org/article/1bc8d018707d44a39253d9ff546904b8
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Most epigenetic information is reprogrammed during gametogenesis and early development. However, some epigenetic information persists and can be inherited, a phenomenon that is common in plants. On the other hand, there are increasing examples of epi
Externí odkaz:
https://doaj.org/article/4f3ab6b6813149148734deca088292e5
Autor:
Yanghua He, Robert L. Taylor, Jr., Hao Bai, Christopher M. Ashwell, Keji Zhao, Yaokun Li, Guirong Sun, Huanmin Zhang, Jiuzhou Song
Publikováno v:
Poultry Science, Vol 102, Iss 12, Pp 103036- (2023)
Marek's disease virus (MDV), a naturally oncogenic, highly contagious alpha herpesvirus, induces a T cell lymphoma in chickens that causes severe economic loss. Marek's disease (MD) outcome in an individual is attributed to genetic and environmental
Externí odkaz:
https://doaj.org/article/d319400e11ee497cb3ba567ff524a5d5
Autor:
Mark T. Mc Auley
Publikováno v:
Experimental Gerontology, Vol 179, Iss , Pp 112256- (2023)
In the last decade epigenetics has come to the fore as a discipline which is central to biogerontology. Age associated epigenetic changes are routinely linked with pathologies, including cardiovascular disease, cancer, and Alzheimer's disease; moreov
Externí odkaz:
https://doaj.org/article/b423180570de4d3cbabeb9565ec9df6e