Zobrazeno 1 - 10
of 7 271
pro vyhledávání: '"TRANSCRIPTIONAL ACTIVITY"'
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Objectives Serum/glucocorticoid-inducible kinase 1 (SGK1) gene encodes a serine/threonine protein kinase that plays an essential role in cellular stress response and regulation of multiple metabolic processes. However, its role in bovine adi
Externí odkaz:
https://doaj.org/article/63e7807a6eb74072ac4f3da16000bd9d
Autor:
Gaochan Qin, Mingzhu Pan, Dong Huang, Xinxin Li, Yue Liu, Xiaojun Yu, Kangsen Mai, Wenbing Zhang
Publikováno v:
Cells, Vol 13, Iss 23, p 1949 (2024)
To explore the molecular targets for regulating glucose metabolism in carnivorous fish, the turbot (Scophthalmus maximus) was selected as the research object to study. Farnesoid X receptor (FXR; NR1H4), as a ligand-activated transcription factor, pla
Externí odkaz:
https://doaj.org/article/5a4fd751162642ddb2eaeb7b893024e3
Autor:
Xiangqian Gao, Guiyan Yang, Dapei Li, Muhong Xie, Yujie Mei, Lan Hu, Yongqi Zheng, Evangelia V. Avramidou
Publikováno v:
Agriculture, Vol 14, Iss 11, p 2047 (2024)
Rubus idaeus is one of the primary cultivated species of raspberries, renowned for its appealing color, distinctive flavor and numerous health benefits. WIP proteins, which contain three conserved amino acids (W: Tryptophan, I: Isoleucine, P: Proline
Externí odkaz:
https://doaj.org/article/68a1fb8c07de4509adfc44aee7d646f0
Publikováno v:
Molecules, Vol 29, Iss 22, p 5312 (2024)
The expression of therapeutic genes is critical for the efficacy of gene therapy products. However, existing methods such as immunological analysis at the protein level or reverse-transcription PCR at the RNA level are unable to accurately quantify t
Externí odkaz:
https://doaj.org/article/7f1fa865d23646389766262477271d35
Autor:
Yu Wei, Dian Zhang, He Shi, Husun Qian, Hongling Chen, Qian Zeng, Fangfang Jin, Yan Ye, Zuli Ou, Minkang Guo, Bianqin Guo, Tingmei Chen
Publikováno v:
Genes and Diseases, Vol 11, Iss 4, Pp 101041- (2024)
Pyruvate dehydrogenase kinase 1 (PDK1) phosphorylates the pyruvate dehydrogenase complex, which inhibits its activity. Inhibiting pyruvate dehydrogenase complex inhibits the tricarboxylic acid cycle and the reprogramming of tumor cell metabolism to g
Externí odkaz:
https://doaj.org/article/50920ea8a3fb4725b15b4adbeb683a89
Autor:
Sydorchuk Larysa, Lytvyn Bogdan, Sydorchuk Andrii, Yarynych Yulia, Daruvuri Sai Praveen, Semenenko Svitlana, Hoshovska Alisa, Sydorchuk Ruslan, Biryuk Igor
Publikováno v:
Endocrine Regulations, Vol 58, Iss 1, Pp 195-205 (2024)
Objective. The aim of this study was to evaluate the association of the α-adducin-1 gene (ADD1) (Gly460Trp [rs4961]) polymorphism and its expression in association with renal dysfunction and sodium sensitivity in hypertensive patients in western Ukr
Externí odkaz:
https://doaj.org/article/9d90904d3bad45e49e523e8705c106ce
Publikováno v:
Cell Regeneration, Vol 12, Iss 1, Pp 1-13 (2023)
Abstract Naïve pluripotent state can be obtained by several strategies from various types of cells, in which the cell fate roadmap as well as key biological events involved in the journey have been described in detail. Here, we carefully explored th
Externí odkaz:
https://doaj.org/article/63795d3103fe4022ae6dbc97daff140d
Autor:
Long-Long Yang, Xin-Yu Zhang, Li-Ying Wang, Yan-Ge Li, Xiao-Ting Li, Yi Yang, Qing Su, Ning Chen, Yu-Lan Zhang, Ning Li, Chuan-Liang Deng, Shu-Fen Li, Wu-Jun Gao
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Background Long terminal repeat (LTR)-retrotransposons (LTR-RTs) are ubiquitous and make up the majority of nearly all sequenced plant genomes, whereas their pivotal roles in genome evolution, gene expression regulation as well as their epig
Externí odkaz:
https://doaj.org/article/282d64129ad14e449ab761b984cfc66e
Publikováno v:
Virology Journal, Vol 20, Iss 1, Pp 1-10 (2023)
Abstract Background High-risk human papillomaviruses (HPVs) are responsible for the development of cervical and other anogenital cancers. Intratype sequence variants of certain high-risk HPV types (e.g. 16, 18 and 31) are thought to have different on
Externí odkaz:
https://doaj.org/article/5231750f82774ab9b2d16c7cd45a6562
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-11 (2023)
Abstract FOXM1 (Forkhead box M1) is an oncogenic transcription factor that is greatly upregulated in breast cancer and many other cancers where it promotes tumorigenesis, and cancer growth and progression. It is expressed in all subtypes of breast ca
Externí odkaz:
https://doaj.org/article/1ca00effc74743619a82dfd0a0897736