Zobrazeno 1 - 10
of 28 968
pro vyhledávání: '"TRANSACTIVATION"'
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-23 (2024)
Abstract Transactivation of epidermal growth factor receptors (EGFR) provides intricate control over multiple regulatory cellular processes that merge the diversity of G protein-coupled receptors (GPCRs) with the robust signaling capacities of recept
Externí odkaz:
https://doaj.org/article/c809f781c35341f786a27114164239b3
Akademický článek
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Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
P65, a protein subunit of NF-κB, is a widely distributed transcription factor in eukaryotic cells and exerts diverse regulatory functions. Post-translational modifications such as phosphorylation, acetylation, methylation and ubiquitination modulate
Externí odkaz:
https://doaj.org/article/67b5adc33c6a4ba7a43a3420d2e07234
Publikováno v:
Biochemistry and Biophysics Reports, Vol 38, Iss , Pp 101667- (2024)
The ETV6-MECOM fusion gene, produced by the rare and recurrent chromosomal translocation t(3; 12) (q26; p13), is associated with high mortality and short survival in myeloid leukemia. However, its function and underlying mechanisms in leukemia progre
Externí odkaz:
https://doaj.org/article/73dd715c4edd49b698d3f7c9f902fba2
Autor:
David A. Vesey, Abishek Iyer, Evan Owen, Danielle Kamato, David W. Johnson, Glenda C. Gobe, David P. Fairlie, David J. Nikolic-Paterson
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Key features of chronic kidney disease (CKD) include tubulointerstitial inflammation and fibrosis. Protease activated receptor-2 (PAR2), a G-protein coupled receptor (GPCR) expressed by the kidney proximal tubular cells, induces potent proinflammator
Externí odkaz:
https://doaj.org/article/acd3f424f03c4ce7a40cc0c7435e9fc3
Autor:
Amanda Lopes da Silva, Bruno Luiz Miranda Guedes, Samuel Nascimento Santos, Giovanna Francisco Correa, Ariane Nardy, Luiz Henrique da Silva Nali, Andre Luis Lacerda Bachi, Camila Malta Romano
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
The notion that viruses played a crucial role in the evolution of life is not a new concept. However, more recent insights suggest that this perception might be even more expansive, highlighting the ongoing impact of viruses on host evolution. Endoge
Externí odkaz:
https://doaj.org/article/592478b15b83471398eed2091df05e2f
Akademický článek
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Akademický článek
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Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-17 (2023)
Abstract HIV-1 remains a global health concern and to date, nearly 38 million people are living with HIV. The complexity of HIV-1 pathogenesis and its subsequent prevalence is influenced by several factors including the HIV-1 subtype. HIV-1 subtype v
Externí odkaz:
https://doaj.org/article/61d83d15d75f4a9dbcb35ba12026b466
Autor:
Ekaterina M. Zhidkova, Leyla R. Tilova, Timur I. Fetisov, Kirill I. Kirsanov, Evgeny P. Kulikov, Adel D. Enikeev, Irina V. Budunova, Gennadii A. Badun, Maria G. Chernysheva, Valerii Z. Shirinian, Marianna G. Yakubovskaya, Ekaterina A. Lesovaya
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8904 (2024)
Glucocorticoids (GCs) are widely used for treating hematological malignancies despite their multiple adverse effects. The biological response to GCs relies on glucocorticoid receptor (GR) transrepression (TR) that mediates the anticancer effects and
Externí odkaz:
https://doaj.org/article/b75ad0ba91b04240a79d0a95e6cbc916