Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes.

Autor: Ogasawara D; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: daisuke@scripps.edu., Konrad DB; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA., Tan ZY; Immunology Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Carey KL; Immunology Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Luo J; Immunology Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Won SJ; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA., Li H; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA., Carter TR; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA., DeMeester KE; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA., Njomen E; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA., Schreiber SL; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Xavier RJ; Immunology Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Melillo B; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: bmelillo@scripps.edu., Cravatt BF; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: cravatt@scripps.edu.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2024 Dec 19; Vol. 31 (12), pp. 2138-2155.e32. Date of Electronic Publication: 2024 Nov 14.

SuFEx-based chemical diversification for the systematic discovery of CRBN molecular glues.

Autor: Carter TR; Department of Chemistry, The Scripps Research Institute, United States., Milosevich N; Department of Chemistry, The Scripps Research Institute, United States., Dada L; Department of Biochemistry, Albert Einstein College of Medicine, United States., Shaum JB; Department of Chemistry, The Scripps Research Institute, United States., Barry Sharpless K; Department of Chemistry, The Scripps Research Institute, United States., Kitamura S; Department of Chemistry, The Scripps Research Institute, United States; Department of Biochemistry, Albert Einstein College of Medicine, United States., Erb MA; Department of Chemistry, The Scripps Research Institute, United States.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Apr 15; Vol. 104, pp. 117699. Date of Electronic Publication: 2024 Apr 04.

A Four-channel Optically Pumped Magnetometer for a Magnetoencephalography Sensor Array.

Autor: Iivanainen J, Carter TR, Dhombridge JE, Read TS, Campbell K, Abate Q, Ridley DM, Borna A, Schwindt PDD

Publikováno v: ArXiv [ArXiv] 2023 Dec 22. Date of Electronic Publication: 2023 Dec 22.

Single-trial classification of evoked responses to auditory tones using OPM- and SQUID-MEG.

Autor: Iivanainen J; Sandia National Laboratories, Albuquerque, NM 87185, United States of America., Carter TR; Sandia National Laboratories, Albuquerque, NM 87185, United States of America., Trumbo MCS; Sandia National Laboratories, Albuquerque, NM 87185, United States of America., McKay J; Candoo Systems Inc, Port Coquitlam, BC, Canada., Taulu S; University of Washington, Seattle, WA, United States of America., Wang J; Department of Speech, Language, and Hearing Sciences, The University of Texas at Austin, Austin, TX, United States of America.; Department of Neurology, The University of Texas at Austin, Austin, TX, United States of America., Stephen JM; The Mind Research Network a Division of Lovelace Biomedical Research Institute, Albuquerque, NM 87106, United States of America., Schwindt PDD; Sandia National Laboratories, Albuquerque, NM 87185, United States of America., Borna A; Sandia National Laboratories, Albuquerque, NM 87185, United States of America.

Publikováno v: Journal of neural engineering [J Neural Eng] 2023 Oct 06; Vol. 20 (5). Date of Electronic Publication: 2023 Oct 06.

Development of VU6019650 : A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M 5 Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder.

Autor: Garrison AT; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Orsi DL; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Capstick RA; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Whomble D; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Li J; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Carter TR; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Felts AS; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Vinson PN; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Rodriguez AL; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Han A; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Hajari K; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Cho HP; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Teal LB; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Ragland MG; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Ghamari-Langroudi M; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Bubser M; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Chang S; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Schnetz-Boutaud NC; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Boutaud O; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Blobaum AL; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Foster DJ; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States.; Vanderbilt Kennedy Center, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Niswender CM; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States.; Vanderbilt Kennedy Center, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Conn PJ; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States.; Vanderbilt Kennedy Center, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Lindsley CW; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States.; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, United States., Jones CK; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States., Han C; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Apr 28; Vol. 65 (8), pp. 6273-6286. Date of Electronic Publication: 2022 Apr 13.