Zobrazeno 1 - 10
of 226
pro vyhledávání: '"TPL2"'
Autor:
Yuanyuan Wang, Tiffany Wu, Ming-Chi Tsai, Mitchell G Rezzonico, Alyaa M Abdel-Haleem, Luke Xie, Vineela D Gandham, Hai Ngu, Kimberly Stark, Caspar Glock, Daqi Xu, Oded Foreman, Brad A Friedman, Morgan Sheng, Jesse E Hanson
Publikováno v:
eLife, Vol 12 (2023)
Tumor progression locus 2 (TPL2) (MAP3K8) is a central signaling node in the inflammatory response of peripheral immune cells. We find that TPL2 kinase activity modulates microglial cytokine release and is required for microglia-mediated neuron death
Externí odkaz:
https://doaj.org/article/0de297db33c643f2ae2e401f38b89b3b
Autor:
Serkan Ismail Göktuna
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 21, Pp 436-453 (2022)
IKBKE have been associated with numerous cancers. As a result, IKBKE have emerged as potential target for cancer therapy. Accumulating evidence support that IKBKE orchestrate tumor cell survival in cancers. Here we evaluated the possible link between
Externí odkaz:
https://doaj.org/article/61f437f8d8724caf8f6e5af7c053c9a1
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Excessive inflammation in patients with severe influenza disease may lead to acute lung injury that results in acute respiratory distress syndrome (ARDS). ARDS is associated with alveolar damage and pulmonary edema that severely impair gas e
Externí odkaz:
https://doaj.org/article/70a6d14eeee34cc5b7768114305903de
Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Tumor progression locus 2 (Tpl2) is a serine-threonine kinase known to promote inflammation in response to various pathogen-associated molecular patterns (PAMPs), inflammatory cytokines and G-protein-coupled receptors and consequently aids in host re
Externí odkaz:
https://doaj.org/article/6868df64b6104dada2d61d1b3763c951
Akademický článek
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Akademický článek
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Autor:
Zhe Qiang, Zong-yuan Zhou, Ting Peng, Pu-zi Jiang, Nan Shi, Emmanuel Mfotie Njoya, Bahtigul Azimova, Wan-li Liu, Wei-hua Chen, Guo-lin Zhang, Fei Wang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-15 (2018)
Abstract Background Drugs that inhibit the MEK/ERK pathway have therapeutic benefit in bladder cancer treatment but responses vary with patients, for reasons that are still not very clear. Interferon-α (IFN-α) is also used as a therapeutic agent fo
Externí odkaz:
https://doaj.org/article/7378701b6d8647c5862510b9d26271f5
Autor:
Anna Chorzalska, Nagib Ahsan, R. Shyama Prasad Rao, Karim Roder, Xiaoqing Yu, John Morgan, Alexander Tepper, Steven Hines, Peng Zhang, Diana O. Treaba, Ting C. Zhao, Adam J. Olszewski, John L. Reagan, Olin Liang, Philip A. Gruppuso, Patrycja M. Dubielecka
Publikováno v:
Molecular Oncology, Vol 12, Iss 5, Pp 630-647 (2018)
The introduction of tyrosine kinase inhibitors (TKI) has transformed chronic myeloid leukemia (CML) into a chronic disease with long‐term survival exceeding 85%. However, resistance of CML stem cells to TKI may contribute to the 50% relapse rate ob
Externí odkaz:
https://doaj.org/article/61e7c5610dee4650acd0483ee9489b8a
Autor:
Yasser Morsy, Nathalie Brillant, Yannick Franc, Michael Scharl, Marcin Wawrzyniak, on behalf of the Swiss IBD Cohort Study Group
Publikováno v:
Cells, Vol 10, Iss 12, p 3589 (2021)
Background: The single nucleotide polymorphism (SNP) rs1042058 within the gene locus encoding tumor progression locus 2 (TPL2) has been recently identified as a risk gene for inflammatory bowel disease (IBD). TPL2 has been shown to regulate pro-infla
Externí odkaz:
https://doaj.org/article/86511608606b44c5bad591b0d67467a7