Zobrazeno 1 - 10
of 645
pro vyhledávání: '"TPH1"'
Autor:
Jorge D. Oldan, Benjamin C. Giglio, Eric Smith, Weiling Zhao, Deeanna M. Bouchard, Marija Ivanovic, Yueh Z. Lee, Frances A. Collichio, Michael O. Meyers, Diana E. Wallack, Amber Abernethy-Leinwand, Patricia K. Long, Dimitri G. Trembath, Paul B. Googe, Madeline H. Kowalski, Anastasia Ivanova, Jennifer A. Ezzell, Nana Nikolaishvili-Feinberg, Nancy E. Thomas, Terence Z. Wong, David W. Ollila, Zibo Li, Stergios J. Moschos
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTClinical trials of combined IDO/PD1 blockade in metastatic melanoma (MM) failed to show additional clinical benefit compared to PD1-alone inhibition. We reasoned that a tryptophan-metabolizing pathway other than the kynurenine one is essentia
Externí odkaz:
https://doaj.org/article/ef023c41d8c54761886b2eb17171d130
Autor:
Jadwiga Snarska, Ewa Fiedorowicz, Dominika Rozmus, Konrad Wroński, Maria Latacz, Natalia Kordulewska, Janusz Płomiński, Roman Grzybowski, Huub F.J. Savelkoul, Elżbieta Kostyra, Anna Cieślińska
Publikováno v:
BMC Gastroenterology, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background The role of serotonin and its metabolic pathway in proper functioning of the pancreas has not been thoroughly investigated yet in acute pancreatitis (AP) patients. Tryptophan hydroxylase (TPH) as the rate-limiting enzyme of seroto
Externí odkaz:
https://doaj.org/article/31ff4eaf50e44e12b1208130a13c5f04
Akademický článek
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Autor:
Sergey A. Sinenko, Andrey A. Kuzmin, Elena V. Skvortsova, Sergey V. Ponomartsev, Evgeniya V. Efimova, Michael Bader, Natalia Alenina, Alexey N. Tomilin
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4862 (2023)
The monoamine neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has important functions both in the neural system and during embryonic development in mammals. In this study, we set out to investigate whether and how endogenous serotonin affects
Externí odkaz:
https://doaj.org/article/2155db7bd6a245439ae46e6bba42ecc0
Autor:
Giulia Sbrini, Sabrina I. Hanswijk, Paola Brivio, Anthonieke Middelman, Michael Bader, Fabio Fumagalli, Natalia Alenina, Judith R. Homberg, Francesca Calabrese
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4941 (2022)
Serotonin is synthetized through the action of tryptophan hydroxylase (TPH) enzymes. While the TPH2 isoform is responsible for the production of serotonin in the brain, TPH1 is expressed in peripheral organs. Interestingly, despite its peripheral loc
Externí odkaz:
https://doaj.org/article/0d32b3b54d2345e5964bbdd298267006
Akademický článek
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Akademický článek
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Autor:
Sara Crotti, Alessandra Fraccaro, Chiara Bedin, Antonella Bertazzo, Valerio Di Marco, Salvatore Pucciarelli, Marco Agostini
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
In locally advanced rectal cancer patients (LARC), preoperative chemoradiation improves local control and sphincter preservation. The response rate to treatment varies substantially between 20 and 30%, and it is an important prognostic factor. Indeed
Externí odkaz:
https://doaj.org/article/7a613e561dbf4d09864b97f2ae8c2cab
Publikováno v:
Journal of Functional Foods, Vol 72, Iss , Pp 104077- (2020)
The present study aimed to evaluate the effects of the probiotic Lactobacillus rhamnosus GG (L.GG) on the serotonergic pathway in an animal model of peptic tryptic digested gliadin (PTG)-induced enteropathy that mimics celiac disease (CD). The seroto
Externí odkaz:
https://doaj.org/article/5d52297008ba40c59d241ebbcaece150
Autor:
Kei Sonoyama, Tatsuya Morita, Takumi Tochio, Shingo Hino, Misa Tatsuoka, Yosuke Osaki, Fumina Ohsaka, Yoshihiro Kadota, Takeshi Tsuruta
Publikováno v:
British journal of nutrition. 127(4):513-525
SCFA increase serotonin (5-hydroxytryptamine, 5-HT) synthesis and content in the colon in vitro and ex vivo, but little is known in vivo. We tested whether dietary indigestible saccharides, utilised as a substrate to produce SCFA by gut microbiota, w