Zobrazeno 1 - 10
of 1 377
pro vyhledávání: '"TP53 mutations"'
Autor:
Monika Chomczyk, Luca Gazzola, Shubhankar Dash, Patryk Firmanty, Binsah S. George, Vakul Mohanty, Hussein A. Abbas, Natalia Baran
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Acute myeloid leukemia (AML), an aggressive malignancy of hematopoietic stem cells, is characterized by the blockade of cell differentiation, uncontrolled proliferation, and cell expansion that impairs healthy hematopoiesis and results in pancytopeni
Externí odkaz:
https://doaj.org/article/62f15b57d34d4c05bbdf5ed4eaf23111
Autor:
Jan Mueller, Roman R Schimmer, Christian Koch, Florin Schneiter, Jonas Fullin, Veronika Lysenko, Christian Pellegrino, Nancy Klemm, Norman Russkamp, Renier Myburgh, Laura Volta, Alexandre PA Theocharides, Kari J Kurppa, Benjamin L Ebert, Timm Schroeder, Markus G Manz, Steffen Boettcher
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 3, Pp 445-474 (2024)
Abstract TP53-mutant acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) are characterized by chemotherapy resistance and represent an unmet clinical need. Chimeric antigen receptor (CAR) T-cells might be a promising therapeutic option f
Externí odkaz:
https://doaj.org/article/3995291a6c424aeaadea031a81b64f56
Autor:
Waled Bahaj, Tariq Kewan, Carmelo Gurnari, Arda Durmaz, Ben Ponvilawan, Ishani Pandit, Yasuo Kubota, Olisaemeka D. Ogbue, Misam Zawit, Yazan Madanat, Taha Bat, Suresh K. Balasubramanian, Hussein Awada, Ramsha Ahmed, Minako Mori, Manja Meggendorfer, Torsten Haferlach, Valeria Visconte, Jaroslaw P. Maciejewski
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-12 (2023)
Abstract Background TP53 mutations (TP53 MT ) occur in diverse genomic configurations. Particularly, biallelic inactivation is associated with poor overall survival in cancer. Lesions affecting only one allele might not be directly leukemogenic, ques
Externí odkaz:
https://doaj.org/article/be24204f0e834aaeb1aa9535926fa7e7
Optimal therapy for concomitant EGFR and TP53 mutated non-small cell lung cancer: a real-world study
Autor:
Haiyan Sun, Peng Ren, Yongzi Chen, Lan Lan, Zhuchen Yan, Yinli Yang, Bin Wang, Cong Wang, Yanwei Li, Ling Li, Yu Zhang, Yanyang Li, Zuolin Wang, Zhanyu Pan, Zhansheng Jiang
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Non-small cell cancer (NSCLC) patients with concomitant epidermal growth factor receptor (EGFR) and TP53 mutations have a poor prognosis with the treatment of tyrosine kinase inhibitors (TKIs), and may benefit from a combination r
Externí odkaz:
https://doaj.org/article/1653c72bed624742b25f78080094ec29
Autor:
Naval G. Daver, Shahed Iqbal, Camille Renard, Rebecca J. Chan, Ken Hasegawa, Hao Hu, Preston Tse, Jiajun Yan, Michael J. Zoratti, Feng Xie, Giridharan Ramsingh
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-14 (2023)
Abstract Background TP53 mutations, which are present in 5% to 10% of patients with acute myeloid leukemia (AML), are associated with treatment resistance and poor outcomes. First-line therapies for TP53-mutated (TP53m) AML consist of intensive chemo
Externí odkaz:
https://doaj.org/article/c0275210a5c448528e89d7f16677c7e9
Publikováno v:
Cells, Vol 13, Iss 4, p 345 (2024)
Ovarian cancer is a leading cause of death among women with gynecological cancers, and is often diagnosed at advanced stages, leading to poor outcomes. This review explores genetic aspects of high-grade serous, endometrioid, and clear-cell ovarian ca
Externí odkaz:
https://doaj.org/article/5728409826c34b96a69df8b4a2cf9481
TP53 mutations correlate with the non‐coding RNA content of small extracellular vesicles in melanoma
Autor:
Maureen Labbé, Estelle Menoret, Franck Letourneur, Benjamin Saint‐Pierre, Laurence deBeaurepaire, Joëlle Veziers, Brigitte Dreno, Marc G. Denis, Christophe Blanquart, Nicolas Boisgerault, Jean‐François Fonteneau, Delphine Fradin
Publikováno v:
Journal of Extracellular Biology, Vol 2, Iss 8, Pp n/a-n/a (2023)
Abstract Non‐coding RNAs (ncRNAs) are important regulators of gene expression. They are expressed not only in cells, but also in cell‐derived extracellular vesicles (EVs). The mechanisms controlling their loading and sorting remain poorly underst
Externí odkaz:
https://doaj.org/article/782c4b8f9bf447e38e1bc9e1dc7db0ed
Publikováno v:
Open Medicine, Vol 17, Iss 1, Pp 2046-2051 (2022)
Although the incidence of multiple primary malignancies (MPMs) is increasing, synchronous triple primary malignant tumours with prostate, bladder and lung is rarely reported. Gene mutation is thought to be a reason for MPMs, and severe cardiovascular
Externí odkaz:
https://doaj.org/article/b1e5e8a76e084b12a6e08cefcc35daed
Autor:
Lanxin Zhang, Siwen Sun, Xiaotian Zhao, Jingwen Liu, Yang Xu, Lingzhi Xu, Chen Song, Na Li, Jing Yu, Shanshan Zhao, Peiyao Yu, Fengqi Fang, Jiping Xie, Xuening Ji, Ruoying Yu, Qiuxiang Ou, Zuowei Zhao, Man Li
Publikováno v:
Molecular Oncology, Vol 16, Iss 20, Pp 3689-3702 (2022)
Approximately 30% of breast cancer (BC) patients suffer from disease relapse after definitive treatment. Monitoring BC at baseline and disease progression using comprehensive genomic profiling would facilitate the prediction of prognosis. We retrospe
Externí odkaz:
https://doaj.org/article/d8a35b9fa8fb4c60be1f45ee129fa64e
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