Thymopentin-Mediated Inhibition of Cancer Stem Cell Stemness Enhances the Cytotoxic Effect of Oxaliplatin on Colon Cancer Cells

Autor: Peng-Cheng Yu, Di Liu, Zeng-Xiang Han, Fang Liang, Cui-Yun Hao, Yun-Tao Lei, Chang-Run Guo, Wen-Hui Wang, Xing-Hua Li, Xiao-Na Yang, Chang-Zhu Li, Ye Yu, Ying-Zhe Fan

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Thymopentin (TP5) is an immunomodulatory pentapeptide that has been widely used in malignancy patients with immunodeficiency due to radiotherapy and chemotherapy. Here, we propose that TP5 directly inhibits the stemness of colon cancer cells HCT116 a

Externí odkaz: https://doaj.org/article/70253ece0db944ec84cb0da7dd676d7d

Therapeutic effects of TP5, a Cdk5/p25 inhibitor, in in vitro and in vivo models of Parkinson’s disease

Autor: Judith Tran, Shane K.B. Taylor, Anika Gupta, Niranjana Amin, Harish Pant, Bhagwati P. Gupta, Ram K. Mishra

Publikováno v: Current Research in Neurobiology, Vol 2, Iss , Pp 100006- (2021)

Parkinson’s Disease (PD) is a chronic progressive neurodegenerative disease. Current treatments for PD are symptomatic and only increase striatal dopamine levels. Proactive neuroprotective approaches that slow the progression of PD and maintain app

Externí odkaz: https://doaj.org/article/4d8c304bddba48bc9a9dacb9f7347148

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Novel Hybrid Peptide Cathelicidin 2 (1-13)-Thymopentin (TP5) and Its Derived Peptides with Effective Antibacterial, Antibiofilm, and Anti-Adhesion Activities

Autor: Marhaba Ahmat, Xu-Biao Wei, Junyong Wang, Meng-Yao Liu, Yucui Tong, Tian-Tian Yang, Pei-Yao Chen, Jing Zhang, Zheng-Chang Hua, Rijun Zhang, Zaheer Abbas, Xiao-Na Yan, Zhong-Xuan Li, Xiudong Liao, Qiang Cheng, Henan Guo, Hui-Li Wang, Lu-Lu Zhang

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 11681, p 11681 (2021)
Volume 22
Issue 21

The increasing numbers of infections caused by multidrug-resistant (MDR) pathogens highlight the urgent need for new alternatives to conventional antibiotics. Antimicrobial peptides have the potential to be promising alternatives to antibiotics becau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002cec4e11444812ca973339124120cc
https://pubmed.ncbi.nlm.nih.gov/34769113

Targeting the TLR2 Receptor With a Novel Thymopentin-Derived Peptide Modulates Immune Responses

Autor: Yucui Tong, Manyi Zhang, Xubiao Wei, Rujuan Wu, Rijun Zhang, Qiang Cheng, Dayong Si, Lulu Zhang, James N. Petitte, Henan Guo, Yanfei Hou, Baseer Ahmad

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)

The innate and adaptive immune systems act in concert to protect us from infectious agents and other harmful substances. As a state of temporary or permanent immune dysfunction, immunosuppression can make an organism more susceptible to infection, or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fd1318821b9ed9620705bef371b074
http://europepmc.org/articles/PMC8191578