Zobrazeno 1 - 10
of 98 970
pro vyhledávání: '"TP248.13-248.65"'
Autor:
A. V. Tumaev, D. Yu. Voloshin, E. S. Berdinskikh, E. L. Sakhibgaraeva, E. V. Golovin, E. N. Subcheva, O. O. Vasileva, A. A. Galieva, A. A. Chuvashov, E. S. Novikova, A. V. Karabelsky
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 24, Iss 2, Pp 200-214 (2024)
INTRODUCTION. The development of adeno-associated virus (AAV)-based gene therapy products in Russia requires establishing reference standards, which are used throughout the pharmaceutical development cycle, and monitoring their stability during the s
Externí odkaz:
https://doaj.org/article/017e1b55522343728f9311ceb3341351
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 24, Iss 2, Pp 172-187 (2024)
INTRODUCTION. The current cell-based cartilage repair methods, such as autologous chondrocyte transplantation, are not sufficiently effective, and the surgery is painful and traumatic. Therefore, there is a need for a more effective cell therapy prod
Externí odkaz:
https://doaj.org/article/0044305a9bd74c4b994656cb0c2cae0f
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 24, Iss 2, Pp 188-199 (2024)
INTRODUCTION. The use of cationic liposomes is a promising approach to the delivery of therapeutic nucleic acids to target cells because liposomes can protect nucleic acids from degradation by extracellular nucleases. However, to ensure selective del
Externí odkaz:
https://doaj.org/article/43cf04fb55474591be5c22a513f37ce2
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 24, Iss 2, Pp 140-156 (2024)
INTRODUCTION. The development of malignant neoplasms is associated with changes in the expression of small non-coding RNAs (miRNAs). This emphasises the need for research into the development of miRNA-targeted inhibitors as a promising approach to ca
Externí odkaz:
https://doaj.org/article/6690babde4ae4d89b7cb5b8712c94f88
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 24, Iss 2, Pp 123-139 (2024)
INTRODICTION. Currently, gene therapy based on adeno-associated virus (AAV) vectors faces a number of barriers, both biomedical and technological, which require studying and overcoming for further development of this gene therapy technology.AIM. This
Externí odkaz:
https://doaj.org/article/71be6780a74542e89f7c57e1138ef4ad
Autor:
D. O. Maksimov, D. A. Naumova, E. A. Astakhova, V. V. Artemev, S. A. Biryukov, I. S. Abramov, A. A. Navoikova, N. V. Rudev, S. G. Feoktistova, O. V. Glazova, O. N. Mityaeva, P. Yu. Volchkov
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 24, Iss 2, Pp 215-228 (2024)
INTRODUCTION. The creation of synthetic adeno-associated virus (AAV) vectors during gene therapy development is a labour-intensive and expensive process. The optimal solution to minimise the time and costs associated with gene therapy development lie
Externí odkaz:
https://doaj.org/article/ca88668e6b554917a47143e75b0e751a
Autor:
I. P. Shilovskiy, G. B. Pasikhov, V. V. Smirnov, I. A. Kofiadi, M. V. Popova, P. A. Strueva, M. R. Khaitov
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 24, Iss 2, Pp 157-171 (2024)
INTRODUCTION. Small interfering RNAs (siRNAs) are among the most promising types of therapeutic nucleic acids aiming at the inhibition of pathogenetically relevant gene expression through the RNA interference mechanism. However, the limited bioavaila
Externí odkaz:
https://doaj.org/article/eb2d2fbfb84c4e88a2f8d5a7cea9133d
Autor:
Z. E. Berdnikova, A. S. Tikhonova
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 24, Iss 2, Pp 229-236 (2024)
INTRODUCTION. The distinctive nature and composition of biological medicinal products present certain challenges for the detection of microbial contamination, which affects the reliability of sterility control results. The main challenges associated
Externí odkaz:
https://doaj.org/article/ffef29ef514c4580836fe8812ac6e0ba
Autor:
Segun E. Ibitoye, Chanchal Loha, Rasheedat M. Mahamood, Tien-Chien Jen, Meraj Alam, Ishita Sarkar, Partha Das, Esther T. Akinlabi
Publikováno v:
Bioresources and Bioprocessing, Vol 11, Iss 1, Pp 1-35 (2024)
Abstract Integrating innovation and environmental responsibility has become important in pursuing sustainable industrial practices in the contemporary world. These twin imperatives have stimulated research into developing methods that optimize indust
Externí odkaz:
https://doaj.org/article/8a9168533e9a4596b52f3461eadc3922
Autor:
Xu Deng, Cheng-Cheng Song, Wen-Jing Gu, Yu-Jie Wang, Lu Feng, Xiao-Jian Zhou, Ming-Qiang Zhou, Wei-Cheng Yuan, Yong-Zheng Chen
Publikováno v:
Bioresources and Bioprocessing, Vol 11, Iss 1, Pp 1-9 (2024)
Abstract Regioselective and enantioselective hydroxylation of propargylic C-H bonds are useful reactions but often lack appropriate catalysts. Here a green and efficient asymmetric hydroxylation of primary and secondary C–H bonds at propargylic pos
Externí odkaz:
https://doaj.org/article/dc4eebd7ea9b42f397d9ad7fb3d62e48