A retrospective propensity-score-matched cohort study of the impact of procalcitonin testing on antibiotic use in hospitalized patients during the first wave of COVID-19.

Autor: Sandoe JAT; Department of Microbiology, The General Infirmary at Leeds, Leeds, UK.; Healthcare Associated Infection Group, Leeds Institute of Medical Research, University of Leeds, Leeds, UK., Grozeva D; Centre for Trials Research, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK., Albur M; Department of Infection Sciences, Southmead Hospital, North Bristol NHS Trust, Bristol, UK., Bond SE; Pharmacy Department, Mid Yorkshire Teaching NHS Trust, Wakefield, UK., Brookes-Howell L; Centre for Trials Research, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK., Dark P; Division of Immunology, Immunity to Infection and Respiratory Medicine, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Euden J; Centre for Trials Research, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK., Hamilton R; Antibiotic Research UK, York, UK.; School of Pharmacy, De Montfort University, Leicester, UK., Hellyer TP; Royal Victoria Infirmary, Newcastle and Freeman Hospital, Newcastle-upon-Tyne Hospital NHS Foundation Trust, Newcastle-upon-Tyne, UK.; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK., Henley J; School of Social Sciences, Cardiff University, Cardiff, UK., Hopkins S; UK Health Security Agency, London, UK., Howard P; NHS England and NHS Improvement, North-East and Yorkshire Region, UK., Howdon D; Leeds Institute for Health Sciences, University of Leeds, Leeds, UK., Knox-Macaulay C; Public and Patient Involvement Representative, Centre for Trials Research, Cardiff University, Cardiff, UK., Llewelyn MJ; Brighton and Sussex Medical School, University of Sussex and University Hospitals Sussex NHS Foundation Trust, Brighton, UK., Maboshe W; Centre for Trials Research, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK., McCullagh IJ; Royal Victoria Infirmary, Newcastle and Freeman Hospital, Newcastle-upon-Tyne Hospital NHS Foundation Trust, Newcastle-upon-Tyne, UK.; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK., Ogden M; Public and Patient Involvement Representative, Centre for Trials Research, Cardiff University, Cardiff, UK., Parsons HK; Department of Microbiology, Laboratory Medicine, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Partridge DG; Department of Microbiology, Laboratory Medicine, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Powell N; Pharmacy Department, Royal Cornwall Hospitals NHS Foundation Trust, Truro, UK., Prestwich G; Public and Patient Involvement Representative, Centre for Trials Research, Cardiff University, Cardiff, UK., Shaw D; Leicester NIHR Biomedical Research Centre and Department of Respiratory Sciences, University of Leicester, Leicester, UK., Shinkins B; Leeds Institute for Health Sciences, University of Leeds, Leeds, UK.; Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK., Szakmany T; Critical Care Directorate, Aneurin Bevan University Health Board, Cwmbran, UK.; Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University, Cardiff, UK., Thomas-Jones E; Centre for Trials Research, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK., Todd S; Tropical and Infectious Disease Unit, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., West RM; Leeds Institute for Health Sciences, University of Leeds, Leeds, UK., Carrol ED; Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Pallmann P; Centre for Trials Research, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2024 Nov 04; Vol. 79 (11), pp. 2792-2800.

Developing a model for decision-making around antibiotic prescribing for patients with COVID-19 pneumonia in acute NHS hospitals during the first wave of the COVID-19 pandemic: qualitative results from the Procalcitonin Evaluation of Antibiotic use in COVID-19 Hospitalised patients (PEACH Study).

Autor: Henley J; School of Social Sciences, Cardiff University, Cardiff, UK HenleyJ@cardiff.ac.uk., Brookes-Howell L; Cardiff University Centre for Trials Research, Cardiff, UK., Euden J; College of Biomedical and Life Sciences, Cardiff University Centre for Trials Research, Cardiff, UK., Pallmann P; College of Biomedical and Life Sciences, Cardiff University Centre for Trials Research, Cardiff, UK., Llewelyn M; Brighton and Sussex Medical School, University of Sussex and University Hospitals Sussex NHS Foundation Trust, Brighton, UK., Howard P; School of Healthcare, University of Leeds, Leeds, UK.; Pharmacy, Leeds Teaching Hospitals, Leeds, UK., Powell N; Royal Cornwall Hospitals NHS Trust, Truro, UK., Dark P; Intensive Care Unit, University of Manchester, Salford, UK., Szakmany T; Critical Care Directorate, Aneurin Bevan University Health Board, Newport, UK.; Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff Univeristy, Cardiff, UK., Hellyer TP; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Albur M; Microbiology, North Bristol NHS Trust, Bristol, UK., Hamilton R; School of Pharmacy, De Montfort University, Leicester, UK., Prestwich G; Public Patient Representative, Leeds, UK., Ogden M; Faculty of Social Sciences, University of Stirling, Stirling, UK., Maboshe W; Cardiff University Centre for Trials Research, Cardiff, UK., Sandoe J; Department of Microbiology, The General Infirmary at Leeds, Leeds, UK.; Healthcare Associated Infection Group, Leeds Institute of Medical Research, University of Leeds, Leeds, UK., Thomas-Jones E; Cardiff University Centre for Trials Research, Cardiff, UK., Carrol E; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.

Publikováno v: BMJ open [BMJ Open] 2023 Dec 19; Vol. 13 (12), pp. e077117. Date of Electronic Publication: 2023 Dec 19.

Tracheostomy in children is associated with neutrophilic airway inflammation.

Autor: Powell J; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK jason.powell@doctors.org.uk.; Department of Paediatric Otolaryngology, Great North Children's Hospital, Newcastle upon Tyne, UK., Powell S; Department of Paediatric Otolaryngology, Great North Children's Hospital, Newcastle upon Tyne, UK., Mather MW; Department of Paediatric Otolaryngology, Great North Children's Hospital, Newcastle upon Tyne, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Beck L; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Nelson A; Department of Applied Science, Northumbria University, Newcastle upon Tyne, UK., Palmowski P; Protein and Proteome Facility, Newcastle University, Newcastle upon Tyne, UK., Porter A; Protein and Proteome Facility, Newcastle University, Newcastle upon Tyne, UK., Coxhead J; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Hedley A; Bioinformatics Support Unit, Newcastle University, Newcastle upon Tyne, UK., Scott J; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Rostron AJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Hellyer TP; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Zaidi F; Discovery and Translational Science, Metabolon, Morrisville, North Carolina, USA., Davey T; Electron Microscopy Research Services, Newcastle University, Newcastle upon Tyne, UK., Garnett JP; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Agbeko R; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Department of Paediatric Intensive Care, Great North Children's Hospital, Newcastle upon Tyne, UK., Ward C; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Stewart CJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Taggart CC; Experimental Medicine, Queen's University Belfast, Belfast, UK., Brodlie M; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Department of Paediatric Respiratory Medicine, Great North Children's Hospital, Newcastle upon Tyne, UK., Simpson AJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.

Publikováno v: Thorax [Thorax] 2023 Oct; Vol. 78 (10), pp. 1019-1027. Date of Electronic Publication: 2023 Feb 20.

Nitration of chemokine CXCL8 acts as a natural mechanism to limit acute inflammation.

Autor: Thompson S; Immunity and Inflammation Theme, Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Pang CY; Immunity and Inflammation Theme, Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Sepuru KM; Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch, Galveston, TX, 77555, USA., Cambier S; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000, Leuven, Belgium., Hellyer TP; Immunity and Inflammation Theme, Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Department of Critical Care Medicine, Royal Victoria Infirmary, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, NE1 4LP, UK., Scott J; Immunity and Inflammation Theme, Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Simpson AJ; Immunity and Inflammation Theme, Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Department of Respiratory Medicine, Royal Victoria Infirmary, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE1 4L9, UK., Proost P; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000, Leuven, Belgium., Kirby JA; Immunity and Inflammation Theme, Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Rajarathnam K; Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch, Galveston, TX, 77555, USA. krrajara@utmb.edu.; Institute for Human Infections and Immunity, The University of Texas Medical Branch, Galveston, TX, 77555, USA. krrajara@utmb.edu., Sheerin NS; Immunity and Inflammation Theme, Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. Neil.Sheerin@newcastle.ac.uk., Ali S; Immunity and Inflammation Theme, Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. Simi.Ali@newcastle.ac.uk.

Publikováno v: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2023 Jan 09; Vol. 80 (1), pp. 35. Date of Electronic Publication: 2023 Jan 09.

Development and implementation of a customised rapid syndromic diagnostic test for severe pneumonia.

Autor: Navapurkar V; John V Farman Intensive Care Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Bartholdson Scott J; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, CB2 0AW, UK., Maes M; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, CB2 0AW, UK., Hellyer TP; Translational and Clinical Research Institute, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK.; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE7 7DN, UK., Higginson E; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, CB2 0AW, UK., Forrest S; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, CB2 0AW, UK., Pereira-Dias J; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, CB2 0AW, UK., Parmar S; Clinical Microbiology and Public Health Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Heasman-Hunt E; Clinical Microbiology and Public Health Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Polgarova P; John V Farman Intensive Care Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Brown J; John V Farman Intensive Care Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Titti L; John V Farman Intensive Care Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Smith WP; School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK., Scott J; Translational and Clinical Research Institute, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK., Rostron A; Translational and Clinical Research Institute, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK., Routledge M; Clinical Microbiology and Public Health Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK.; Infectious Diseases, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Sapsford D; Pharmacy Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Török ME; Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK.; Microbiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., McMullan R; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, BT9 7BL, UK., Enoch DA; Clinical Microbiology and Public Health Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Wong V; Clinical Microbiology and Public Health Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK.; Infectious Diseases, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Curran MD; Clinical Microbiology and Public Health Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Brown NM; Clinical Microbiology and Public Health Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Simpson AJ; Translational and Clinical Research Institute, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK.; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE7 7DN, UK., Herre J; Respiratory Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Dougan G; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, CB2 0AW, UK., Conway Morris A; John V Farman Intensive Care Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK.; Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK.

Publikováno v: Wellcome open research [Wellcome Open Res] 2022 Oct 12; Vol. 6, pp. 256. Date of Electronic Publication: 2022 Oct 12 (Print Publication: 2021).