Zobrazeno 1 - 10
of 36
pro vyhledávání: '"TOSHITO NAKAGAWA"'
Autor:
Shun Nakai, Ima Shibata, Takahiro Shitamichi, Hiroyuki Yamaguchi, Nobuyuki Takagi, Tomoaki Inoue, Toshito Nakagawa, Jumpei Kiyokawa, Satoshi Wakabayashi, Tomoya Miyoshi, Eriko Higashi, Seiichi Ishida, Nobuaki Shiraki, Shoen Kume
Publikováno v:
Biology Open, Vol 8, Iss 7 (2019)
Differentiation of stem cells to hepatocytes provides an unlimited supply of human hepatocytes and therefore has been vigorously studied. However, to date, the stem cell-derived hepatocytes were suggested to be of immature features. To obtain matured
Externí odkaz:
https://doaj.org/article/0c22b2ec0c5f4e329edacc35f03e5a7c
Autor:
Mika Sato-Nakai, Kosuke Kawashima, Toshito Nakagawa, Yukako Tachibana, Miyuki Yoshida, Kenji Takanashi, Peter N. Morcos, Martin Binder, David J Moore, Li Yu
Publikováno v:
Heliyon, Vol 3, Iss 7 (2017)
Two metabolites (M4 and M1b) in plasma and four metabolites (M4, M6, M1a and M1b) in faeces were detected through the human ADME study following a single oral administration of [14C]alectinib, a small-molecule anaplastic lymphoma kinase inhibitor, to
Externí odkaz:
https://doaj.org/article/0da9f33de37a4803b60755cf3f88fc57
Autor:
Pascale David Pierson, Christoph Ullmer, Sven Taylor, Tadakatsu Takahashi, Franz Schuler, Monique Schmitt, Rosa María Rodríguez Sarmiento, Olivier Roche, Hans Richter, Susanne Raab, Jean-Marc Plancher, Matthias Nettekoven, Toshito Nakagawa, Peter Mohr, Jörg Huwyler, Cornelia Hertel, Silvia Gatti-Mac Arthur, Christian Freichel, Ruby Wiegand
Publikováno v:
CHIMIA, Vol 63, Iss 5 (2009)
Obesity is a major risk factor for the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease and cancer. Several pieces of evidence, including data in primates, have demonstrated the beneficial effects o
Externí odkaz:
https://doaj.org/article/23147c62779544d7be95c98a70540a3c
Publikováno v:
Pharmaceutical Research. 38:1031-1039
The purpose of this research is to analyze non-linear pharmacokinetics of P-glycoprotein (P-gp) substrates in a cell based assay of a microfluidic device, which might be affected by hydrodynamic barrier (unstirred water layer, UWL). Apparent permeabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d997836218c6c38d381c726ee9ddfb7f
https://doi.org/10.1007/s11095-021-03054-4
https://doi.org/10.1007/s11095-021-03054-4
Autor:
Yoshiaki Watanabe, Haruhiko Sato, Hidetomo Kitamura, Tomoya Kotake, Yoshikazu Nishimura, Masaru Shimizu, Takashi Emura, Kotaro Ogawa, Toru Esaki, Toshito Nakagawa, Akemi Mizutani, Yoshiyuki Furuta, Shinichi Arai, Hiroshi Noda, Masateru Ohta, Tatsuya Tamura, Yoshiaki Isshiki
Publikováno v:
Journal of Medicinal Chemistry. 63:5089-5099
We have previously shown that the oral administration of the small molecule hPTHR1 agonist PCO371 and its lead compound, 1 (CH5447240) results in PTH-like calcemic and hypophostemic activity in thyroparathyroidectomized rats. However, 1 was converted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e990e3b015767e8e07afcf1625e08030
https://doi.org/10.1021/acs.jmedchem.9b01743
https://doi.org/10.1021/acs.jmedchem.9b01743
UR-1102, a novel uricosuric agent for treating gout, has been confirmed to exhibit a pharmacological effect in patients. We clarified its metabolic pathway, estimated the contribution of each metabolic enzyme, and assessed the impact of genetic polym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992f8495873509c3517877754cae9dfc
Autor:
Masaru Shimizu, Yoshikazu Nishimura, Masateru Ohta, Toshito Nakagawa, Yoshiyuki Furuta, Naoki Okamoto, Yoshiaki Isshiki, Haruhiko Sato, Yoshiaki Watanabe, Hitoshi Saito, Hiroshi Noda, Tatsuya Tamura, Tomoya Kotake, Toru Esaki
Publikováno v:
Journal of Medicinal Chemistry. 61:5949-5962
During the course of derivatization of HTS hit 4a, we have identified a novel small-molecule hPTHR1 agonist, 1-(3,5-dimethyl-4-(2-((2-((1R,4R)-4-methylcyclohexyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-1-methylurea (CH544724
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee5e48d9dacf5c4280be8d1ffd84fb9
https://doi.org/10.1021/acs.jmedchem.8b00182
https://doi.org/10.1021/acs.jmedchem.8b00182
Autor:
Jumpei Kiyokawa, Shun Nakai, Takahiro Shitamichi, Toshito Nakagawa, Nobuyuki Takagi, Tomoya Miyoshi, Eriko Higashi, Nobuaki Shiraki, Seiichi Ishida, Satoshi Wakabayashi, Shoen Kume, Hiroyuki Yamaguchi, Tomoaki Inoue, Ima Shibata
Publikováno v:
Biology Open
Biology Open, Vol 8, Iss 7 (2019)
Biology Open, Vol 8, Iss 7 (2019)
Differentiation of stem cells to hepatocytes provides an unlimited supply of human hepatocytes and therefore has been vigorously studied. However, to date, the stem cell-derived hepatocytes were suggested to be of immature features. To obtain matured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe64bfb19d6e15ba397ed94ce4d0a739
http://europepmc.org/articles/PMC6679405
http://europepmc.org/articles/PMC6679405
Autor:
Hiromitsu Kawata, Ayako Nishimoto, Nobuyuki Ishikura, Takao Houjo, Robert L. Vessella, Hitoshi Yoshino, Takashi Emura, Toshito Nakagawa, Kazutaka Tachibana, Haruhiko Sato, Miho Watanabe, Ryo Nakamura, Takuya Shiraishi, Masateru Ohta, Toshiaki Tsunenari, Yuko Aoki, Akie Honma, Eva Corey
Publikováno v:
International Journal of Oncology. 46:1560-1572
Resistance of prostate cancer to castration is currently an unavoidable problem. The major mechanisms underlying such resistance are androgen receptor (AR) overexpression, androgen-independent activation of AR, and AR mutation. To address this proble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e627101cf3300cee571ab61aa5f6c0ee
https://doi.org/10.3892/ijo.2015.2860
https://doi.org/10.3892/ijo.2015.2860
Autor:
Li Yu, Peter N. Morcos, Yukako Tachibana, Kosuke Kawashima, Mika Sato-Nakai, Miyuki Yoshida, David J Moore, Toshito Nakagawa, Martin Binder, Kenji Takanashi
Publikováno v:
Heliyon, Vol 3, Iss 7 (2017)
Heliyon
Heliyon
Two metabolites (M4 and M1b) in plasma and four metabolites (M4, M6, M1a and M1b) in faeces were detected through the human ADME study following a single oral administration of [14C]alectinib, a small-molecule anaplastic lymphoma kinase inhibitor, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a128b94e28456455e0046250e753056b
http://www.sciencedirect.com/science/article/pii/S2405844017311684
http://www.sciencedirect.com/science/article/pii/S2405844017311684