Zobrazeno 1 - 10
of 305
pro vyhledávání: '"TOSHIO NARAHASHI"'
Autor:
Hideaki Tagashira, Kohji Fukunaga, Toshio Narahashi, Jay Z. Yeh, Toru Ishizuka, Yuzuru Sasaki, Shigeki Moriguchi, Yasushi Yabuki, Hiromu Yawo, Norifumi Shioda, Hiroyuki Sakagami
Publikováno v:
Molecular Psychiatry. 23:211-221
Here, we report a novel target of the drug memantine, ATP-sensitive K+ (KATP) channels, potentially relevant to memory improvement. We confirmed that memantine antagonizes memory impairment in Alzheimer's model APP23 mice. Memantine increased CaMKII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4be84a32d2d4f1f97e7a874ef3542f1
https://doi.org/10.1038/mp.2016.187
https://doi.org/10.1038/mp.2016.187
Autor:
Toshio Narahashi, Shigeki Moriguchi, Jay Z. Yeh, Hideaki Tagashira, Hiroyuki Sakagami, Kohji Fukunaga, Yuzuru Sasaki
Publikováno v:
Journal of Neurochemistry. 128:927-937
Because the cholinergic system is down-regulated in the brain of Alzheimer's disease patients, cognitive deficits in Alzheimer's disease patients are significantly improved by rivastigmine treatment. To address the mechanism underlying rivastigmine-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c7e31efdf64ccae22cd7d6123fd411
https://doi.org/10.1111/jnc.12510
https://doi.org/10.1111/jnc.12510
Publikováno v:
Hippocampus. 23:942-951
Sunifiram is a novel pyrrolidone nootropic drug structurally related to piracetam, which was developed for neurodegenerative disorder like Alzheimer's disease. Sunifiram is known to enhance cognitive function in some behavioral experiments such as Mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::496f36357a775c27645ae482a540560b
https://doi.org/10.1002/hipo.22150
https://doi.org/10.1002/hipo.22150
Autor:
Takashi Mori, Miyuki Kuno, Akira Asada, Megumi Hasaka, Tadashi Matsuura, Kiyonobu Nishikawa, Toshio Narahashi
Publikováno v:
NeuroReport. 23:601-605
The purinergic P2X4 receptors (P2X4Rs) of spinal microglia are upregulated after a peripheral nerve injury and play important roles in the pathogenesis of chronic pain. The effects of general anesthetics on chronic pain and the mechanisms are still u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330f176c924de81e223ce520913aaf58
https://doi.org/10.1097/wnr.0b013e32835509db
https://doi.org/10.1097/wnr.0b013e32835509db
Autor:
Megumi Hasaka, Miyuki Kuno, Kiyonobu Nishikawa, Makoto Sawada, Junko Kawawaki, Toshio Narahashi, Takashi Mori, Tadashi Matsuura, Akira Asada
Publikováno v:
The Journal of Physiology. 590:827-844
Voltage-gated proton channels play crucial roles during the respiratory burst in phagocytes, such as microglia. As local anaesthetics have a variety of anti-inflammatory properties, including inhibition of phagocytosis, they may act on the proton cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cf18ff6a6d37e8d56c26b96b374debc
https://doi.org/10.1113/jphysiol.2011.218149
https://doi.org/10.1113/jphysiol.2011.218149
Glutamate-activated chloride channels: Unique fipronil targets present in insects but not in mammals
Publikováno v:
Pesticide Biochemistry and Physiology. 97:149-152
Selectivity to insects over mammals is one of the important characteristics for a chemical to become a useful insecticide. Fipronil was found to block cockroach GABA receptors more potently than rat GABA(A) receptors. Furthermore, glutamate-activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd44d0055ee143fb5d122dfaf1b7ae11
https://doi.org/10.1016/j.pestbp.2009.07.008
https://doi.org/10.1016/j.pestbp.2009.07.008
Autor:
Takeshi Tadano, Shigeki Moriguchi, Osamu Nakagawasai, Yui Yamamoto, Feng Han, Toshio Narahashi, Takeharu Nakajima, Jay Z. Yeh, Kohji Fukunaga, Norifumi Shioda
Publikováno v:
Journal of Neurochemistry. 110:170-181
Aberrant behaviors related to learning and memory in olfactory bulbectomized (OBX) mice have been documented in the previous studies. We reported that the impairment of long-term potentiation (LTP) of hippocampal CA1 regions from OBX mice was associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8e18f859d6a843ce101b46cdaf3bb4
https://doi.org/10.1111/j.1471-4159.2009.06122.x
https://doi.org/10.1111/j.1471-4159.2009.06122.x
Publikováno v:
Journal of Neurochemistry. 106:1092-1103
Nefiracetam is a pyrrolidine-related nootropic drug exhibiting various pharmacological actions such as cognitive-enhancing effect. We previously showed that nefiracetam potentiates NMDA-induced currents in cultured rat cortical neurons. To address qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5efc9ad16af0269fbc5363cb395aff
https://doi.org/10.1111/j.1471-4159.2008.05440.x
https://doi.org/10.1111/j.1471-4159.2008.05440.x
Autor:
Ke Dong, Richard Nass, Windy A. Boyd, Toshio Narahashi, Jonathan H. Freedman, Randall T. Peterson
Publikováno v:
NeuroToxicology. 29:546-555
The field of neurotoxicology needs to satisfy two opposing demands: the testing of a growing list of chemicals, and resource limitations and ethical concerns associated with testing using traditional mammalian species. National and international gove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37b50f439f63203575be111202ed1f5
https://doi.org/10.1016/j.neuro.2008.04.006
https://doi.org/10.1016/j.neuro.2008.04.006
Autor:
Toshio Narahashi
Publikováno v:
Proceedings of the Japan Academy, Series B. 84:147-154
Tetrodotoxin (TTX), contained in puffer, has become an extremely popular chemical tool in the physiological and pharmacological laboratories since our discovery of its channel blocking action in the early 1960s. This brief review describes the histor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe95e7087085b1cea3797f89e8802da8
https://doi.org/10.2183/pjab.84.147
https://doi.org/10.2183/pjab.84.147