Zobrazeno 1 - 10
of 22
pro vyhledávání: '"TOSHIKAZU OGAWA"'
Publikováno v:
Spectroscopy Letters. 42:73-80
金沢大学理工研究域物質化学系
The crystal structures of 5-benzyl-2-thiohydantoin (5-BTH) and 1-acetyl-5-benzyl-2-thiohydantoin (1-Ac-5-BTH) have been determined by X-ray diffraction. In the 5-BTH crystals, the enantiomeric (R)- and
The crystal structures of 5-benzyl-2-thiohydantoin (5-BTH) and 1-acetyl-5-benzyl-2-thiohydantoin (1-Ac-5-BTH) have been determined by X-ray diffraction. In the 5-BTH crystals, the enantiomeric (R)- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30025dc620430ceeda61dfccb3d30dd
https://doi.org/10.1080/00387010802428575
https://doi.org/10.1080/00387010802428575
Autor:
Jiro Hirosumi, Masayuki Tomita, Naomi Hosogai, Seitaro Mutoh, Toshitaka Manda, Kaori Hamada, Toshikazu Ogawa
Publikováno v:
European Journal of Pharmacology. 477:171-178
Our recent study suggests that there is a reciprocal mechanism to maintain cGMP content, via both a decrease in cGMP degradation (decrease in cGMP-phosphodiesterase activity) and an increase in synthesis of cGMP (increase in guanylate cyclase activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5dbb897ceafb6264d1db8e27827e52
https://doi.org/10.1016/j.ejphar.2003.08.014
https://doi.org/10.1016/j.ejphar.2003.08.014
Autor:
Susumu Miyata, Fusako Nishigaki, Shozo Sakuma, Toshitaka Ohkubo, Toshikazu Ogawa, Toshio Goto
Publikováno v:
European Journal of Pharmacology. 437:123-128
FK506 (Tacrolimus) and cyclosporin A exert their immunosuppressive effects via a common mechanism, calcineurin inhibition, after binding to intracellular proteins termed immunophilins: FK506-binding protein (FKBP) and cyclophilin. In this study, FK50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc685a83800d1f088f7090b077bfac13
https://doi.org/10.1016/s0014-2999(02)01269-4
https://doi.org/10.1016/s0014-2999(02)01269-4
Autor:
Shozo Sakuma, Masakazu Kobayashi, Toshikazu Ogawa, Yuka Akiyama, Kouichi Tamura, Takashi Fujitsu, Yasutomo Fujii, Hongsi Jiang
Publikováno v:
Transplant International. 12:92-99
Although tacrolimus has been studied in a wide variety of experimental animal models, we are the first group to systematically study the effect of tacrolimus on rat renal allograft survival, as primary therapy and as anti-rejection therapy, in compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c9080479f2542df3d2b90aeb3f442e
https://doi.org/10.1007/s001470050192
https://doi.org/10.1007/s001470050192
Publikováno v:
Molecular Immunology. 34:663-669
The protein phosphatase calcineurin is known to be an essential intracellular signal transducer involved in the TCR-mediated signal transduction pathway and is the common target of the immunosuppressive drugs cyclosporin A (CsA) and FK506. The cataly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66574ac885bc7473eb86c0ba6c7759f6
https://doi.org/10.1016/s0161-5890(97)00054-0
https://doi.org/10.1016/s0161-5890(97)00054-0
Publikováno v:
Acta Crystallographica Section E Structure Reports Online. 62:o153-o155
金沢大学理工研究域物質化学系
The title compound, C8H12N+·C 23H36,NO3-·H2O, has one molecule of N-tetradecanoyl-L-phenylalanine and one molecule of (R)-l-phenylethylamine as a diastereoisomeric salt, and a water molecule in the as
The title compound, C8H12N+·C 23H36,NO3-·H2O, has one molecule of N-tetradecanoyl-L-phenylalanine and one molecule of (R)-l-phenylethylamine as a diastereoisomeric salt, and a water molecule in the as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c22e496a5686a516fd88a20c88b9cd
https://doi.org/10.1107/s1600536805040511
https://doi.org/10.1107/s1600536805040511
Autor:
KOUCHIT TAMUKA, TAKAO FUJIMURA, TAKESHI TSUTSUMI, KEIKO NAKAMURA, TOSHIKAZU OGAWA, CHIZURU ATLIMARU, YURI HIRANO, KANAME OHARA, KAZUYUKI OHTSUKA, KYOICHI SHIMOMURA, MASAKAZU KOBAYASHI
Publikováno v:
Transplantation. 59:1606-1612
FK506 (tacrolimus) is a strong immunosuppressant: it has been approved as a drug for liver transplantation in Japan, the United States, and the United Kingdom. One of its main adverse effects is hyperglycemia. Thus, in this study, we investigated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66a633b2837ac7472a2a3b71ffba2b92
https://doi.org/10.1097/00007890-199506000-00018
https://doi.org/10.1097/00007890-199506000-00018
Autor:
Susumu Satoh, Hachiro Senoh, Elaine O'Neill, Hiromi Fujiwara, Hidekazu Mizuhara, Chihiro Kusunoki, Kazuyuki Otsuka, Toshikazu Ogawa, Mineo Niwa, Nobuo Seki
Publikováno v:
The Journal of Experimental Medicine
This study investigates the molecular mechanisms underlying the induction of and protection from T cell activation-associated hepatic injury. When BALB/c mice were given a single intravenous injection of concanavalin A (Con A) (> or = 0.3 mg/mouse),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789427229616e3d3496c83fcd9420ac7
https://doi.org/10.1084/jem.179.5.1529
https://doi.org/10.1084/jem.179.5.1529
Publikováno v:
Pharmacology. 63(2)
We established an Ascaris-induced biphasic skin allergic reaction in mice. In the early-phase reaction (EPR), mast cell degranulation was observed, and tranilast inhibited ear edema. In mast-cell-deficient mice (WBB6F1-W/WV mice), ear edema in the EP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5c5f9610aef3a4ef3c02407b2fcaf5
https://pubmed.ncbi.nlm.nih.gov/11490200
https://pubmed.ncbi.nlm.nih.gov/11490200
Publikováno v:
Analytical Sciences: X-ray Structure Analysis Online. 23:x199-x200
The crystal structure of 5-phenyl-2-thioxo-4-imidazolidinone has been determined by X-ray diffraction. The crystal, C9H8N2OS, belongs to space group P1 with cell dimensions of a = 8.971(3)A, b = 9.651(3)A, c = 10.497(3)A, α = 82.39(2)°, β = 80.15(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99bd224c4fca806967e0eba3fd47df81
http://hdl.handle.net/2297/28466
http://hdl.handle.net/2297/28466