mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice

Autor: Alexander S. Ham, Kathrin Chojnowska, Lionel A. Tintignac, Shuo Lin, Alexander Schmidt, Daniel J. Ham, Michael Sinnreich, Markus A. Rüegg

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 1, Pp 259-273 (2020)

Abstract Background The balance between protein synthesis and degradation (proteostasis) is a determining factor for muscle size and function. Signalling via the mammalian target of rapamycin complex 1 (mTORC1) regulates proteostasis in skeletal musc

Externí odkaz: https://doaj.org/article/463dbe3786a54576826b6dcaf9675034

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The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation

Autor: Marino Caruso, Sébastien Meurant, Damien Detraux, Amandine Mathieu, Manon Gilson, Marc Dieu, Antoine Fattaccioli, Catherine Demazy, Mustapha Najimi, Etienne Sokal, Thierry Arnould, Catherine Verfaillie, Denis L.J. Lafontaine, Patricia Renard

Publikováno v: Stem Cell Reports, Vol. 18, no. 1, p. 254-268 (2023)
Caruso, M, Meurant, S, Detraux, D, Mathieu, A, Gilson, M, Dieu, M, Fattaccioli, A, Demazy, C, Najimi, M, Sokal, E, Arnould, T, Verfaillie, C, Lafontaine, D L J & Renard, P 2023, ' The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation ', Stem Cell Reports, vol. 18, no. 1, pp. 254-268 . https://doi.org/10.1016/j.stemcr.2022.11.020

Translational regulation is of paramount importance for proteome remodeling during stem cell differentiation at both the global and the transcript-specific levels. In this study, we characterized translational remodeling during hepatogenic differenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9eede862b95732bd2ab217cf1632f4
https://pubmed.ncbi.nlm.nih.gov/36563686

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