Zobrazeno 1 - 10
of 1 227
pro vyhledávání: '"TNFR1"'
Autor:
Muhammad S. Alam, Matthias M. Gaida, Hagen R. Witzel, Shizuka Otsuka, Aamna Abbasi, Theresa Guerin, Abdalla Abdelmaksoud, Nathan Wong, Margaret C. Cam, Serguei Kozlov, Jonathan D. Ashwell
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101696- (2024)
Summary: Pancreatic adenocarcinoma (PDAC) is one the most intractable cancers, in part due to its highly inflammatory microenvironment and paucity of infiltrating dendritic cells (DCs). Here, we find that genetic ablation or antibody blockade of tumo
Externí odkaz:
https://doaj.org/article/9670d27153fc4e16929024a035649b41
Autor:
Ritasha Sawoo, Biswadev Bishayi
Publikováno v:
Immunobiology, Vol 229, Iss 5, Pp 152840- (2024)
Due to the urgent need to create appropriate treatment techniques, which are currently unavailable, LPS-induced sepsis has become a serious concern on a global scale. The primary active component in the pathophysiology of inflammatory diseases such a
Externí odkaz:
https://doaj.org/article/ca4848d3552e4b7ab693e43fa836c1ed
Autor:
Wei Yang Sit, Mei-Ling Cheng, Tsan-Jan Chen, Chia-Jo Chen, Bo-Nian Chen, Ding-Jun Huang, Pei-Lien Chen, Yun-Ching Chen, Chi-Jen Lo, Deng-Chyang Wu, Wan-Chen Hsieh, Chung-Ting Chang, Ruey-Hwa Chen, Wen-Ching Wang
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Helicobacter pylori, a dominant member of the gastric microbiota was associated with various gastrointestinal diseases and presents a significant challenge due to increasing antibiotic resistance. This study identifies H. pylori’s phospholipase A (
Externí odkaz:
https://doaj.org/article/663a62325ec84f488aef70da7b4ba32c
Publikováno v:
Журнал медико-биологических исследований, Vol 12, Iss 1, Pp 32-39 (2024)
Цель исследования – изучение экспрессии гена TNFR1 в бронхах крыс с овальбумининдуцированной бронхиальной астмой с учетом влияния интра
Externí odkaz:
https://doaj.org/article/d8388e1b85fe483e8149150c587aacab
Autor:
Kyeong Ah Park, Chan Seok Jung, Kyung-Cheol Sohn, Eunjin Ju, Sanghee Shin, InWha Park, MinKyun Na, Gang Min Hur
Publikováno v:
Heliyon, Vol 10, Iss 6, Pp e28092- (2024)
Ubiquitination of RIPK1 plays an essential role in the recruitment of the IKK complex, an upstream component of pro-survival NF-κB. It also limits TNF-induced programmed cell death by inhibiting the spatial transition from TNFR1-associated complex-I
Externí odkaz:
https://doaj.org/article/cd093fc4e66a44d782ed0140992fd3e6
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-22 (2023)
Abstract Background Patients with metastatic triple-negative breast cancer (mTNBC) have a higher probability of developing visceral metastasis within 5 years after the initial diagnosis. Therefore, a deeper understanding of the progression and spread
Externí odkaz:
https://doaj.org/article/96bb062fbf6542e19156f021f5a0be75
Autor:
Daria M. Yurkina, Elena A. Romanova, Kirill A. Shcherbakov, Rustam H. Ziganshin, Denis V. Yashin, Lidia P. Sashchenko
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6633 (2024)
Receptors of cytokines are major regulators of the immune response. In this work, we have discovered two new ligands that can activate the TNFR1 (tumor necrosis factor receptor 1) receptor. Earlier, we found that the peptide of the Tag (PGLYRP1) prot
Externí odkaz:
https://doaj.org/article/acda8c31feb44e5fa229e76f0179cfc1
Autor:
Yi Yang, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Wenyan Li, Caiqun Zhang, Li Guo, Chenyang Han
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/32aeb75708964fc8a79150be17a49fd8
Autor:
Valentina Pegoretti, Jan Bauer, Roman Fischer, Iskra Paro, Wanda Douwenga, Roland E. Kontermann, Klaus Pfizenmaier, Evelien Houben, Bieke Broux, Niels Hellings, Wia Baron, Jon D. Laman, Ulrich L. M. Eisel
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract TNF signaling is an essential regulator of cellular homeostasis. Through its two receptors TNFR1 and TNFR2, soluble versus membrane-bound TNF enable cell death or survival in a variety of cell types. TNF-TNFRs signaling orchestrates importan
Externí odkaz:
https://doaj.org/article/5841bf7052c54683ab34c56469546a89
Autor:
Timon Fiedler, Richard Fairless, Kira Pichi, Roman Fischer, Fabian Richter, Roland E. Kontermann, Klaus Pfizenmaier, Ricarda Diem, Sarah K. Williams
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Background Tumour necrosis factor (TNF) is a pleiotropic cytokine and master regulator of the immune system. It acts through two receptors resulting in often opposing biological effects, which may explain the lack of therapeutic potential ob
Externí odkaz:
https://doaj.org/article/419220a7d4354d2c8e22cb1683c5790a