Zobrazeno 1 - 10
of 54
pro vyhledávání: '"TNFα, tumour necrosis factor α"'
Autor:
Anna M Price, Charles J. Ferro, Larissa Fabritz, Luke Pickup, Richard P. Steeds, Jonathan N. Townend, Ashwin Radhakrishnan, Kirsty McGee, Jonathan P Law, Roxy Senior
Publikováno v:
International Journal of Cardiology
Background Coronary microvascular dysfunction is prevalent in chronic kidney disease (CKD), and may contribute to the development of myocardial dysfunction in CKD. Coronary flow velocity reserve (CFVR) is a marker of coronary microvascular function a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002f9c8b26d13c97133b5438f8bb719e
http://europepmc.org/articles/PMC7584109
http://europepmc.org/articles/PMC7584109
Publikováno v:
JHEP Reports
JHEP Reports, Vol 3, Iss 4, Pp 100295-(2021)
JHEP Reports, Vol 3, Iss 4, Pp 100295-(2021)
Background & Aims Current standard-of-care suppresses HBV replication, but does not lead to a functional cure. Treatment aiming to cure chronic hepatitis B (CHB) is believed to require the induction of strong cellular immune responses, such as by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa6a662c3c140792ac90ba2679e0c6e
http://europepmc.org/articles/PMC8203848
http://europepmc.org/articles/PMC8203848
Autor:
Hilde Herrema, Torsten P. M. Scheithauer, Albert K. Groen, Max Nieuwdorp, Jeffrey Kroon, Abraham S. Meijnikman
Publikováno v:
JHEP Reports
Summary Cellular senescence is a state of irreversible cell cycle arrest that has important physiological functions. However, cellular senescence is also a hallmark of ageing and has been associated with several pathological conditions. A wide range
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49cf6b852a0781adc214c7756b7b84c9
https://pubmed.ncbi.nlm.nih.gov/34113839
https://pubmed.ncbi.nlm.nih.gov/34113839
Publikováno v:
JHEP Reports
Summary HDV is a small, defective RNA virus that requires the HBsAg of HBV for its assembly, release, and transmission. Chronic HBV/HDV infection often has a severe clinical outcome and is difficult to treat. The important role of a robust virus-spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa0b0d9a5a9df24a3799dfa6a9f62d4
https://doi.org/10.1016/j.jhepr.2021.100294
https://doi.org/10.1016/j.jhepr.2021.100294
Autor:
Pei Y. Ng, Riccardo Perbellini, Alfonso Tan-Garcia, Sergio Erdal Irac, Su P. Choo, Evan W. Newell, Nina Le Bert, Jeffrey Chun Tatt Lim, Christine Y.L. Tham, Roberta D'Ambrosio, Elisabetta Degasperi, Lu-En Wai, Antonio Bertoletti, Qingfeng Chen, Charles-Antoine Dutertre, Dan Y. Young, Joe Poh Sheng Yeong, Fritz Lai, Tony Kiat Hon Lim, Rasha Msallam, Florent Ginhoux
Publikováno v:
JHEP Reports
JHEP Reports, Vol 2, Iss 1, Pp-(2020)
JHEP Reports, Vol 2, Iss 1, Pp-(2020)
Background & Aims Chronic liver inflammation leads to fibrosis and cirrhosis and is associated with an accumulation of intrahepatic TNFα-secreting CD206+ macrophages, which may participate in maintaining chronic liver disease in a GM-CSF-dependent m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881a96fcfe34f315d21ab70ebbab498d
https://pubmed.ncbi.nlm.nih.gov/32039403
https://pubmed.ncbi.nlm.nih.gov/32039403
Autor:
Emmerich, Christoph H., Bakshi, Siddharth, Kelsall, Ian R., Ortiz-Guerrero, Juanma, Shpiro, Natalia, Cohen, Philip
Publikováno v:
Biochemical and Biophysical Research Communications
We have reported previously that activation of the MyD88-signaling network rapidly induces the formation of hybrid ubiquitin chains containing both Lys63-linked and Met1-linked ubiquitin (Ub) oligomers, some of which are attached covalently to Interl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2e3cf84b76d359cbd3a99a232d37b0c7
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 563-569 (2014)
Redox Biology
Redox Biology
Curcumin has been shown to have many potentially health beneficial properties in vitro and in animal models with clinical studies on the toxicity of curcumin reporting no major side effects. However, curcumin may chelate dietary trace elements and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34111eb52cef8c02b7b58ec3fd7d6591
http://www.sciencedirect.com/science/article/pii/S2213231714000330
http://www.sciencedirect.com/science/article/pii/S2213231714000330
Autor:
Sarah Mustafa, Heather Martin, Ross B. Mounsey, Michael C. Nelson, Ronald M. Evans, Kinnari Sathe, Peter Teismann
Publikováno v:
Neuroscience
Highlights • We investigate the role of PPARδ in a model of Parkinson’s disease. • PPARδ is upregulated after the neurotoxin MPTP. • PPARδ antagonism enhances MPP+ toxicity which is reversible by PPARδ agonism. • PPARδ agonism protects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddcb5e841eab2aa04672192ba2bb0d2
https://doi.org/10.1016/j.neuroscience.2013.02.058
https://doi.org/10.1016/j.neuroscience.2013.02.058
Autor:
Elsa M. Rodarte, Joo-Heon Yoon, Rustam Bagirzadeh, Zoulikha Azzegagh, Rupesh Nigam, James A. McNew, Binhui Ren, Brenton L. Scott, Youlia Petrova, Kyubo Kim, Michael J. Tuvim, Lucia Piccotti, Anurag Agrawal, Alejandra Gomez, Roberto Adachi, Christopher M. Evans, Burton F. Dickey, Vesa M. Olkkonen
Publikováno v:
Biochemical Journal
Airway mucin secretion and MC (mast cell) degranulation must be tightly controlled for homoeostasis of the lungs and immune system respectively. We found the exocytic protein Munc18b to be highly expressed in mouse airway epithelial cells and MCs, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a16dcc44d03feca71748d207a23da21
https://doi.org/10.1042/bj20120057
https://doi.org/10.1042/bj20120057
Autor:
Irene Locatelli, Francesco Vizzutti, N. Navari, Emanuele Albano, Alessandra Caligiuri, Erica Novo, Maurizio Parola, Massimo Pinzani, W. Delogu, E. Zamara, Fabio Marra, Salvatore Sutti, S. Galastri, E. Vivoli, A. Provenzano, Stefano Milani
Publikováno v:
Clinical Science (London, England : 1979)
Clinical Science
Clinical Science; Vol 123
Clinical Science
Clinical Science; Vol 123
Expression of CCL2 (CC chemokine ligand 2) (or monocyte chemoattractant protein-1) regulates inflammatory cell infiltration in the liver and adipose tissue, favouring steatosis. However, its role in the pathogenesis of steatohepatitis is still uncert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6301da5ba54f78553e0c47b589df9625
http://europepmc.org/articles/PMC3369401
http://europepmc.org/articles/PMC3369401