Zobrazeno 1 - 10
of 7 522
pro vyhledávání: '"TNBC"'
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-22 (2024)
Abstract Background Triple-negative breast cancer (TNBC) has pronounced stemness that is associated with relapse. N6-methyladenosine (m6A) plays a crucial role in shaping cellular behavior by modulating transcript expression. However, the role of m6A
Externí odkaz:
https://doaj.org/article/463580eb58e948299b0e729e1fca659a
Autor:
Xiuli Zhang, S. Peter Goedegebuure, Michael Y. Chen, Rashmi Mishra, Felicia Zhang, Yik Yeung Yu, Kartik Singhal, Lijin Li, Feng Gao, Nancy B. Myers, Tammi Vickery, Jasreet Hundal, Michael D. McLellan, Mark A. Sturmoski, Samuel W. Kim, Ina Chen, Jesse T. Davidson, Narendra V. Sankpal, Stephanie Myles, Rama Suresh, Cynthia X. Ma, Ademuyiwa Foluso, Andrea Wang-Gillam, Sherri Davies, Ian S. Hagemann, Elaine R. Mardis, Obi Griffith, Malachi Griffith, Christopher A. Miller, Ted H. Hansen, Timothy P. Fleming, Robert D. Schreiber, William E. Gillanders
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Neoantigen vaccines can induce or enhance highly specific antitumor immune responses with minimal risk of autoimmunity. We have developed a neoantigen DNA vaccine platform capable of efficiently presenting both HLA class I and II
Externí odkaz:
https://doaj.org/article/361f87535f3347da8e2cfda87d75ab59
Autor:
Xiaoxiao Zuo, Xiaohan Zhao, Xiaofei Zhang, Qingyuan Li, Xingyu Jiang, Shumei Huang, Xuwei Chen, Xiangfu Chen, Weihua Jia, Hequn Zou, Dongni Shi, Xueke Qian
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-16 (2024)
Abstract Background Cancer metastasis remains a major challenge in the clinical management of triple-negative breast cancer (TNBC). The NF-κB signaling pathway has been implicated as a crucial factor in the development of metastases, but the underly
Externí odkaz:
https://doaj.org/article/cb78a0c0ad7244c9bf7b7d070c1fe19e
Autor:
Goel PN, Katsumata M, Qian W, Mathur S, Ji MQ, Samanta A, Grover P, Sgouros G, Chang JC, Greene MI
Publikováno v:
Breast Cancer: Targets and Therapy, Vol Volume 16, Pp 725-733 (2024)
Peeyush N Goel,1,2,* Makoto Katsumata,3,* Wei Qian,4 Sunil Mathur,4 Mei Q Ji,1 Arabinda Samanta,1 Payal Grover,1 George Sgouros,5 Jenny C Chang,4 Mark I Greene1 1Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Un
Externí odkaz:
https://doaj.org/article/d56b31beaa78444e97ed9254dd811474
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Chronic inflammation and NLRP3 inflammasome activation are among the determining factors of breast malignancies. Paclitaxel (PTX) is a drug used in breast cancer treatment which sustains prolonged inflammation, reducing the effectiveness of
Externí odkaz:
https://doaj.org/article/7cea1cd7940a44d3ad68974f26a90af6
Autor:
Anouchka Coste Holt, Courtney A. Smith, Maurice J. Berkowitz, Jennifer L. Baker, Nicholas P. McAndrew, Nimmi S. Kapoor
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Purpose Adding pembrolizumab to neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC) improves pathologic complete response (pCR) rates and event-free survival. The impact of adding immunotherapy to NAC on surgical outcomes
Externí odkaz:
https://doaj.org/article/2705ab03abf14a5bb30ea2310267a7da
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Cancer stem cells (CSCs) have the potential to self-renew and induce cancer, which may contribute to a poor prognosis by enabling metastasis, recurrence, and therapy resistance. Hence, this study was performed to identify the association bet
Externí odkaz:
https://doaj.org/article/8824695dcd1b4090affa6514bc9533fb
Autor:
Chrispus Ngule, Ruyi Shi, Xingcong Ren, Hongyan Jia, Felix Oyelami, Dong Li, Younhee Park, Jinhwan Kim, Hami Hemati, Yi Zhang, Xiaofang Xiong, Andrew Shinkle, Nathan L. Vanderford, Sara Bachert, Binhua P. Zhou, Jianlong Wang, Jianxun Song, Xia Liu, Jin-Ming Yang
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-23 (2024)
Abstract Triple negative breast cancer (TNBC) is a particularly lethal breast cancer (BC) subtype driven by cancer stem cells (CSCs) and an immunosuppressive microenvironment. Our study reveals that nucleus accumbens associated protein 1 (NAC1), a me
Externí odkaz:
https://doaj.org/article/f74140f6f5a14ff3a6bfa413df989010
Autor:
Carolina Carlosama, Cindy Arévalo, María Camila Jimenez, Paola Lasso, Claudia Urueña, Susana Fiorentino, Alfonso Barreto
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Tumor metabolism is a crucial aspect of cancer development, and mitochondria plays a significant role in the aggressiveness and metastasis of tumors. As a result, mitochondria have become a promising therapeutic target in cancer treatment, l
Externí odkaz:
https://doaj.org/article/8cff2678565a44d9a698f467022f5443
Autor:
Soheila Montazersaheb, Aziz Eftekhari, Amir Shafaroodi, Soodeh Tavakoli, Sara Jafari, Ayşe Baran, Mehmet Fırat Baran, Sevda Jafari, Elham Ahmadian
Publikováno v:
Cancer Nanotechnology, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Background Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. Radiation therapy (RT) is a modality for TNBC management. Radiosensitizers can mitigate the adverse effects of RT. Applying green-synthesized silver n
Externí odkaz:
https://doaj.org/article/51089754c8d34974ad89b929a7939fa0