Chloroquine Dosing Recommendations for Pediatric COVID‐19 Supported by Modeling and Simulation

Autor: Tjitske M van der Zanden, Saskia N. de Wildt, Frans G. M. Russel, Laurens F. M. Verscheijden, TN Johnson, Lianne P M van Bussel, Marika de Hoop-Sommen

Publikováno v: Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics, 108, 2, pp. 248-252
Clinical Pharmacology and Therapeutics, 108, 248-252
Clinical Pharmacology & Therapeutics
Clinical Pharmacology and Therapeutics, 108(2), 248-252. Wiley-Blackwell

Contains fulltext : 225414.pdf (Publisher’s version ) (Open Access) As chloroquine (CHQ) is part of the Dutch Centre for Infectious Disease Control coronavirus disease 2019 (COVID-19) experimental treatment guideline, pediatric dosing guidelines ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3368c3982ff87ae8a0cf2801a9fc45
http://europepmc.org/articles/PMC7264731

Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method

Autor: Elke H. J. Krekels, Elisa A. M. Calvier, Amin Rostami-Hodjegan, Catherijne A. J. Knibbe, Dick Tibboel, TN Johnson

Publikováno v: AAPS Journal, 21(3):Unsp 38. Springer New York
Calvier, E A M, Krekels, E H J, Johnson, T N, Rostami-Hodjegan, A, Tibboel, D & Knibbe, C A J 2019, ' Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism : A Simulation Study to Search for the Simplest Scaling Method ', AAPS Journal, vol. 21, no. 3, 38 . https://doi.org/10.1208/s12248-019-0295-0
The AAPS Journal
AAPS Journal, 21(3), 38

Previous research showed that scaling drug clearance from adults to children based on body weight alone is not accurate for all hepatically cleared drugs in very young children. This study systematically assesses the accuracy of scaling methods that,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782eb04e5c8043ac66994ce7a8895b53
https://pure.eur.nl/en/publications/ccc5df5b-4704-4d8a-b33c-a369c2167e57

Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future

Autor: SN de Wildt, Lawrence J. Lesko, J Boiani, J. S. Leeder, Niloufar Marsousi, Amin Rostami-Hodjegan, Alexander A. Vinks, Athena F. Zuppa, Adam S. Darwich, Kayode Ogungbenro, Michael Neely, Leon Aarons, Paolo Vicini, Youssef Daali, TN Johnson, C. A. J. Knibbe, Jeannine S. McCune, J. R. Powell, James M. Cook, J-L Reny, D Fairman

Publikováno v: Clinical Pharmacology & Therapeutics, 101(5), 646-656. Wiley-Blackwell
Clinical Pharmacology and Therapeutics, 101, 5, pp. 646-656
Clinical Pharmacology and Therapeutics, 101, 646-656
Clinical Pharmacology and Therapeutics, Vol. 101, No 5 (2017) pp. 646-656
Darwich, A, Ogungbenro, K, Vinks, A A, Powell, J R, Reny, J-L, Marsousi, N, Daali, Y, Fairman, D, Cook, J, Lesko, L J, McCune, J S, Knibbe, C A J, de Wildt, S N, Leeder, J S, Neely, M N, Zuppa, A F, Vicini, P, Aarons, L, Johnson, T N, Boiani, J & Rostami-Hodjegan, A 2017, ' Why has model-informed precision dosing not yet become common clinical reality? Lessons from the past and a roadmap for the future ', Clinical Pharmacology & Therapeutics . https://doi.org/10.1002/cpt.659

Item does not contain fulltext Patient groups prone to polypharmacy and special subpopulations are susceptible to suboptimal treatment. Refined dosing in special populations is imperative to improve therapeutic response and/or lowering the risk of to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e093e184dffced0a86f5bdc936df3f2
https://pure.eur.nl/en/publications/5b047b0e-521f-4858-b9a2-9be56bee6d3b

The Effect of Age on Drug Metabolism

Autor: Saskia N. de Wildt, Imti Choonara, TN Johnson

Publikováno v: Paediatric and Perinatal Drug Therapy. 5:101-106

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4307ab7409e3a5fbb1c7ee0d6d78d68
https://doi.org/10.1185/146300903322012013

Developmental Changes in the Processes Governing Oral Drug Absorption

Autor: Miriam G. Mooij, Saskia N. de Wildt, TN Johnson, Barbara A. E. de Koning

Publikováno v: Pediatric Formulations ISBN: 9781489980106

Pharmacotherapy in children often consists of oral medication. Effectiveness of oral prescriptions may be influenced by extrinsic (formulation, nutrition, and co-medication) and intrinsic factors (physiological and disease-related variation).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a63fce5ac2ba7e173d98af41ea9a4826
https://doi.org/10.1007/978-1-4899-8011-3_3