Zobrazeno 1 - 10
of 1 410
pro vyhledávání: '"TMZ"'
Autor:
Alireza Mafi, Neda Hedayati, Samaneh Kahkesh, Sara Khoshayand, Mina Alimohammadi, Najma Farahani, Kiavash Hushmandi
Publikováno v:
Non-coding RNA Research, Vol 9, Iss 4, Pp 1178-1189 (2024)
As the deadliest type of primary brain tumor, gliomas represent a significant worldwide health concern. Circular RNA (circRNA), a unique non-coding RNA molecule, seems to be one of the most alluring target molecules involved in the pathophysiology of
Externí odkaz:
https://doaj.org/article/5aca89d4ff464442878d6c9c54f79e18
Autor:
Tingting Yang, Nan Zhang, Yuanyuan Liu, Ruyue Yang, Zhaoyi Wei, Futai Liu, Dan Song, Longwei Wang, Jiangyan Wei, Yuanpei Li, Deliang Shen, Gaofeng Liang
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Gliomas are one of the most frequent primary brain tumors and pose a serious threat to people’s lives and health. Platelets, a crucial component of blood, have been applied as drug delivery carriers for disease diagnosis and treatment. In
Externí odkaz:
https://doaj.org/article/0d03be8434d245d0849ce7789d6de7bd
Autor:
Francesca Giammello, Chiara Biella, Erica Cecilia Priori, Matilde Amat Di San Filippo, Roberta Leone, Francesca D’Ambrosio, Martina Paterno’, Giulia Cassioli, Antea Minetti, Francesca Macchi, Cristina Spalletti, Ilaria Morella, Cristina Ruberti, Beatrice Tremonti, Federica Barbieri, Giuseppe Lombardi, Riccardo Brambilla, Tullio Florio, Rossella Galli, Paola Rossi, Federico Brandalise
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-28 (2024)
Abstract Background Glioblastoma (GBM) stands as the most prevalent and aggressive form of adult gliomas. Despite the implementation of intensive therapeutic approaches involving surgery, radiation, and chemotherapy, Glioblastoma Stem Cells contribut
Externí odkaz:
https://doaj.org/article/f620b5142f8b4c7d9c81860a86cd23a7
Autor:
Changxiao Yang, Ziwei Li, Kaifu Tian, Xiangqi Meng, Xinyu Wang, Dan Song, Xuan Wang, Tianye Xu, Penggang Sun, Junzhe Zhong, Yu Song, Wenbin Ma, Yuxiang Liu, Daohan Yu, Ruofei Shen, Chuanlu Jiang, Jinquan Cai
Publikováno v:
Advanced Science, Vol 11, Iss 44, Pp n/a-n/a (2024)
Abstract Temozolomide (TMZ) resistance is one of the major reasons for poor prognosis in patients with glioblastoma (GBM). Long noncoding RNAs (lncRNAs) are involved in multiple biological processes, including TMZ resistance. Linc00942 is a potential
Externí odkaz:
https://doaj.org/article/a29bc6c0c2a849cd92c3bcd582ccb7f3
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionGlioma represents the most prevalent primary malignant tumor in the central nervous system, a deeper understanding of the underlying molecular mechanisms driving glioma is imperative for guiding future treatment strategies. Emerging evide
Externí odkaz:
https://doaj.org/article/0712ae347f2745c4bc81622fa93deb5c
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 916-926 (2024)
UBE2C is overexpressed in gliomas, and its overexpression has been reported to be correlated with the drug resistance of gliomas to some extent. In this study, we explore the role of UBE2C in regulating temozolomide (TMZ) resistance in glioma and inv
Externí odkaz:
https://doaj.org/article/54b5445433a144d190a96a436321c21a
Autor:
Jing Wang, Lei Tian, Tasha Barr, Lewei Jin, Yuqing Chen, Zhiyao Li, Ge Wang, Jian-Chang Liu, Li-Shu Wang, Jianying Zhang, David Hsu, Mingye Feng, Michael A. Caligiuri, Jianhua Yu
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 3, Pp 200824- (2024)
Limited therapeutic options are available for patients with breast cancer brain metastases (BCBM), and thus there is an urgent need for novel treatment approaches. We previously engineered an effective oncolytic herpes simplex virus 1 (oHSV) expressi
Externí odkaz:
https://doaj.org/article/b03901e2c0404d4bafa98fbbe8c6c84b
Autor:
Jun Yu, Yonghua Xue
Publikováno v:
PeerJ, Vol 12, p e17979 (2024)
Objectives This study aims to develop brain-targeted temozolomide (TMZ) nanograins using the biodegradable polymer material PEG-PLA as a carrier. The model drug TMZ was encapsulated within the polymer using targeted nanotechnology. Key characteristic
Externí odkaz:
https://doaj.org/article/bf58945a85b843f19f64f6582525ce48
Autor:
Priya Bisht, Surendra Rajit Prasad, Khushboo Choudhary, Ruchi Pandey, Dande Aishwarya, Vulli Aravind, Peraman Ramalingam, Ravichandiran Velayutham, Nitesh Kumar
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Glioblastoma, which affects a large number of patients every year and has an average overall lifespan of around 14.6 months following diagnosis stands out as the most lethal primary invasive brain tumor. Currently, surgery, radiation, a
Externí odkaz:
https://doaj.org/article/e0b0d82c52544a8dacf0b0ab59c3492e
Autor:
Haoyue Xu, Yongkang Zhang, Linfeng Li, Yanhong Ren, Feng Qian, Lansheng Wang, Hongwei Ma, Ankang Quan, Hongmei Liu, Rutong Yu
Publikováno v:
Drug Delivery, Vol 30, Iss 1, Pp 1-13 (2023)
AbstractTemozolomide (TMZ) is a conventional chemotherapeutic drug for glioma, however, its clinical application and efficacy is severely restricted by its drug resistance properties. O6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzy
Externí odkaz:
https://doaj.org/article/e3fe945b662e44c1b0e9c54de47fea6a