Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates

Autor: Xin-Hui Zhang, Hong-Min Liu, Yongfang Yao, Li-Ying Ma, Xue-Jian Feng, Qin Shangshang, Tingting Yu, Bing Zhao, De-Quan Yu, Xiaoling Zhang, Ying Liu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 203-221 (2021)
Acta Pharmaceutica Sinica. B

New Delhi metallo-β-lactamase-1 (NDM-1) is capable of hydrolyzing nearly all β-lactam antibiotics, posing an emerging threat to public health. There are currently less effective treatment options for treating NDM-1 positive “superbug”, and no p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44e2471539ae24953ab00f10282f4be
http://www.sciencedirect.com/science/article/pii/S2211383520306316

Aromatic ginger (Kaempferia galanga L.) extracts with ameliorative and protective potential as a functional food, beyond its flavor and nutritional benefits

Autor: Karuna Shanker, Shilpi Singh, Amit Chand Gupta, Ranjana, Suaib Luqman, Dnyaneshwar U. Bawankule, Nupur Srivastava

Publikováno v: Toxicology Reports, Vol 6, Iss, Pp 521-528 (2019)
Toxicology Reports

Graphical abstract
Highlights • Aromatic ginger is rich in essential nutrients showing potential chemopreventive potential. • Dried aromatic ginger and its hydro-distillate contains EPMC, 2.24% and 52.54%, respectively. • In-vitro antiprol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5950bc1b1c6f7215f7384573bd002960
http://www.sciencedirect.com/science/article/pii/S2214750019300393

Accurate conventional and microwave-assisted synthesis of galloyl hydrazide

Autor: Amgad M. Rabie

Publikováno v: MethodsX
MethodsX, Vol 7, Iss, Pp 100737-(2020)

Graphical abstract
The usefulness of the structure of galloyl hydrazide (3,4,5-trihydroxybenzohydrazide, coded as 2nz in this article) as a privileged structural system in pharmaceutical organic and medicinal chemistry has prompted the advances

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8685895691847c8c96ab4b4d55c4b833
https://doi.org/10.1016/j.mex.2019.11.010

Investigation on the changes of carotenoids and capsaicinoids in chili oil at different frying temperature by using ¹ H NMR.

Autor: Bai X; School of Light Industry and Food Engineering, Guangxi University, Nanning, Guangxi, 530004, China.; Department of Food Science, Guangxi University, Nanning, Guangxi, 530004, China., Wan P; School of Light Industry and Food Engineering, Guangxi University, Nanning, Guangxi, 530004, China.; Department of Food Science, Guangxi University, Nanning, Guangxi, 530004, China., Liu J; School of Light Industry and Food Engineering, Guangxi University, Nanning, Guangxi, 530004, China.; Department of Food Science, Guangxi University, Nanning, Guangxi, 530004, China., Yao J; School of Light Industry and Food Engineering, Guangxi University, Nanning, Guangxi, 530004, China.; Department of Food Science, Guangxi University, Nanning, Guangxi, 530004, China., Chen DW; Department of Food Science, Guangxi University, Nanning, Guangxi, 530004, China.

Publikováno v: Current research in food science [Curr Res Food Sci] 2022 Dec 05; Vol. 6, pp. 100411. Date of Electronic Publication: 2022 Dec 05 (Print Publication: 2023).

Discovery of thiosemicarbazone derivatives as effective New Delhi metallo- β -lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates.

Autor: Zhao B; State Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China., Zhang X; State Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China., Yu T; State Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China., Liu Y; State Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China., Zhang X; State Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China., Yao Y; State Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China., Feng X; State Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China., Liu H; State Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China., Yu D; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China., Ma L; State Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China., Qin S; State Key Laboratory of Esophageal Cancer Prevention and Treament, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Pharmaceutical Research and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.

Publikováno v: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Jan; Vol. 11 (1), pp. 203-221. Date of Electronic Publication: 2020 Jul 16.