Výsledky vyhledávání - "TMPMgCl.LiCl"

Selective ortho-Metalation of a Fluoroarene with Knochel–Hauser Base and Reactions with Various Electrophiles

Autor: Yifan Jiang, Gopu Kasinathan, Markus Baenziger, Sumesh Eswaran

Publikováno v: Synthesis. 51:1649-1654

Selective ortho-metalation of 1-bromo-2-(1,1-difluoroethyl)-4-fluorobenzene was achieved with the Knochel–Hauser base (TMPMgCl·LiCl) in position 5 of the aromatic ring. The magnesiated intermediate was reacted with a variety of electrophiles to ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::887b6f7e921b81a6de8e0e74cc686ef3
https://doi.org/10.1055/s-0037-1611938

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Selective functionalization of cyano-phenyl-2-oxazolines using TMPMgCl·LiCl

Autor: Leandro A. Bozzini, Giuliano C. Clososki, João H. C. Batista, Ricardo Vessecchi, Murilo B. M. de Mello

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Metalated phenyl-2-oxazolines bearing cyano groups can be selectively obtained through the reaction of TMPMgCl·LiCl with the appropriate substrate. Subsequent reaction with different electrophiles furnished the functionalized derivatives in good yie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef9e220e6172a60c1cbd897070ec0fe
https://doi.org/10.1016/j.tetlet.2017.09.051

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Regioselective ortho-functionalization of bromofluorenecarbaldehydes using TMPMgCl·LiCl

Autor: Dominik Göbel, Nils Clamor, Boris J. Nachtsheim

Publikováno v: Organicbiomolecular chemistry. 16(22)

A highly regioselective functionalization of 7-bromofluorene-2-carbaldehydes, potent organic chromophores, in position C3 using a mild ortho-metallation strategy (DoM) with TMPMgCl·LiCl has been developed. This approach allows the preparation of hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eec7a5c245fafba70016189d2e1969e
https://pubmed.ncbi.nlm.nih.gov/29785418

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Directed Functionalization of Cyano-Substituted Furans and Thiophenes with TMPMgCl·LiCl

Autor: Ricardo Vessecchi, Fernanda Santos, João H. C. Batista, Giuliano C. Clososki

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

A number of novel difunctionalized furans and thiophenes has been prepared by the reaction of the cyano-substituted substrates with TMPMgCl·LiCl followed by the reaction with electrophiles. The crucial metalation step takes place under mild conditio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394087e3719ad8f41b2b428a751e799a
https://doi.org/10.1055/s-0035-1560586

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ChemInform Abstract: Directed Functionalization of Cyano-Substituted Furans and Thiophenes with TMPMgCl·LiCl

Autor: João H. C. Batista, Fernanda Santos, Giuliano C. Clososki, Ricardo Vessecchi

Publikováno v: ChemInform. 47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::672d15108b35bc3465ed23fd47b31698
https://doi.org/10.1002/chin.201618109

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Regioselective Functionalization of the Thiazole Scaffold Using TMPMgCl·LiCl and TMP2Zn·2MgCl2·2LiCl

Autor: Paul Knochel, Cora Dunst

Publikováno v: The Journal of Organic Chemistry. 76:6972-6978

A general method for the synthesis of 2,4,5-trisubstituted thiazoles has been developed. Starting from commercially available 2-bromothiazole, successive metalations using TMPMgCl·LiCl or TMP(2)Zn·2MgCl(2)·2LiCl lead to the corresponding magnesate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8957facc8cf78e88b68e73dca47f416b
https://doi.org/10.1021/jo201250n

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Regio- and Chemoselective Multiple Functionalization of Pyrimidine Derivatives by Selective Magnesiations using TMPMgCl·LiCl

Autor: Marc Mosrin, Paul Knochel

Publikováno v: Organic Letters. 10:2497-2500

Successive regio- and chemoselective magnesiations of pyrimidines using TMPMgCl.LiCl furnish, after trapping with various electrophiles, highly functionalized derivatives in good to excellent yields. Applications to the synthesis of antiviral and ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c01bd7cc7f57ba33aadbf934bc15120
https://doi.org/10.1021/ol800790g

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ChemInform Abstract: Continuous Flow Magnesiation of Functionalized Heterocycles and Acrylates with TMPMgCl·LiCl

Autor: Paul Knochel, Matthias R. Becker, Trine P. Petersen

Publikováno v: ChemInform. 46

The flow system allows the metallation under conditions which are more convenient than the batch method.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d22229469d1b25777a204b203bef731e
https://doi.org/10.1002/chin.201503056

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Continuous flow magnesiation of functionalized heterocycles and acrylates with TMPMgCl⋅LiCl

Autor: Paul Knochel, Matthias R. Becker, Trine P. Petersen

Publikováno v: Angewandte Chemie (International ed. in English). 53(30)

A flow procedure for the metalation of functionalized heterocycles (pyridines, pyrimidines, thiophenes, and thiazoles) and various acrylates using the strong, non-nucleophilic base TMPMgCl⋅LiCl is reported. The flow conditions allow the magnesiatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2b048219cfe505ae35f749c9f5a076
https://pubmed.ncbi.nlm.nih.gov/24962240

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