Zobrazeno 1 - 10
of 1 327
pro vyhledávání: '"TMEM16A"'
Autor:
Eamon Dubaissi, Emma N. Hilton, Sarah Lilley, Richard Collins, Charlotte Holt, Peter March, Henry Danahay, Martin Gosling, Richard K Grencis, Ian S Roberts, David J Thornton
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The TMEM16A chloride channel is proposed as a therapeutic target in cystic fibrosis, where activation of this ion channel might restore airway surface hydration and mitigate respiratory symptoms. While TMEM16A is associated with increased mu
Externí odkaz:
https://doaj.org/article/862848294a45463c8ad8b0615eb98903
Autor:
Mercè Cases, Jonatan Dorca‐Arévalo, Marta Blanch, Sergi Rodil, Beatrice Terni, Mireia Martín‐Satué, Artur Llobet, Juan Blasi, Carles Solsona
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 5, Pp n/a-n/a (2024)
Abstract The epsilon toxin (Etx) from Clostridium perfringens has been identified as a potential trigger of multiple sclerosis, functioning as a pore‐forming toxin that selectively targets cells expressing the plasma membrane (PM) myelin and lympho
Externí odkaz:
https://doaj.org/article/914e5c64d72f4982908239b999830e6a
Autor:
Kai-Ting Huang, Larry E Wagner, Takahiro Takano, Xiao-Xuan Lin, Harini Bagavant, Umesh Deshmukh, David I Yule
Publikováno v:
eLife, Vol 13 (2024)
The molecular mechanisms leading to saliva secretion are largely established, but factors that underlie secretory hypofunction, specifically related to the autoimmune disease Sjögren’s syndrome (SS) are not fully understood. A major conundrum is t
Externí odkaz:
https://doaj.org/article/e07abbfbd21f45a2aa0390bf625a9080
Akademický článek
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Akademický článek
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Autor:
Abdulkader Yassin-Kassab, Suman Chatterjee, Nayel Khan, Nathaniel Wang, Vlad C. Sandulache, Eric H-B. Huang, Timothy F. Burns, Umamaheswar Duvvuri
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Head and neck squamous cell carcinoma (HNSCC) constitutes one of the most common types of human cancers and often metastasizes to lymph nodes. Platinum-based chemotherapeutic drugs are commonly used for treatment of a wide range of cancers,
Externí odkaz:
https://doaj.org/article/51729d77fd4f4e76a3435a6037e5e191
Autor:
Pongkorpsakol P, Yimnual C, Satianrapapong W, Worakajit N, Kaewin S, Saetang P, Rukachaisirikul V, Muanprasat C
Publikováno v:
Journal of Experimental Pharmacology, Vol Volume 15, Pp 449-466 (2023)
Pawin Pongkorpsakol,1,* Chantapol Yimnual,2,* Wilasinee Satianrapapong,3 Nichakorn Worakajit,4 Suchada Kaewin,2 Praphatsorn Saetang,5 Vatcharin Rukachaisirikul,5 Chatchai Muanprasat2 1Princess Srisavangavadhana College of Medicine, Chulabhorn
Externí odkaz:
https://doaj.org/article/f3cfabe75f4d47b496f88fcfff6b5eed
Publikováno v:
European Pharmaceutical Journal, Vol 70, Iss 1, Pp 1-7 (2023)
The family of calcium-activated chloride channels, TMEM16, plays a significant role in contributing to the pathogenesis of airway inflammatory diseases. Targeting these ion channels and aiming to modulate them may provide an interesting new approach
Externí odkaz:
https://doaj.org/article/e94d798a96ca48d3a8a605bee732118b
Autor:
Martina Zangari, Giuliano Zabucchi, Martina Conti, Paola Lorenzon, Violetta Borelli, Andrew Constanti, Francesco Dellisanti, Sara Leone, Lisa Vaccari, Annalisa Bernareggi
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8661 (2024)
Many years ago, asbestos fibers were banned and replaced by synthetic vitreous fibers because of their carcinogenicity. However, the toxicity of the latter fibers is still under debate, especially when it concerns the early fiber interactions with bi
Externí odkaz:
https://doaj.org/article/c2d09eee0987498bb1e595b04839bab3