Výsledky vyhledávání - "TMD—transmembrane domain"

The repertoire of ABC proteins in Clostridioides difficile

Autor: Methinee Pipatthana, Surang Chankhamhaengdecha, Somsak Likhitrattanapisal, Tavan Janvilisri, Matthew Phanchana, Phurt Harnvoravongchai, Pisut Pongchaikul

Publikováno v: Computational and Structural Biotechnology Journal
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 2905-2920 (2021)

Graphical abstract
Highlights • ABC transporters transport substrates across membranes driven by ATP hydrolysis. • ABC proteins of C. difficile 630 can be classified into 12 sub-families. • Most NPs are found within sub-families involving

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e9053af190d87883dd74f55d18bd6d
http://europepmc.org/articles/PMC8144104

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Structural modeling of a novel membrane-bound globin-coupled sensor in Geobacter sulfurreducens

Autor: Claudio D. Schuster, David Hoogewijs, Sabine Van Doorslaer, Salvador I. Drusin, Luc Moens, Sylvia Dewilde, Catherine Vénien-Bryan, Marcelo A. Martí, Frank Sobott, Dietmar Hammerschmid, Charline Fagnen, Francesca Germani

Publikováno v: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, 2021, 19, pp.1874-1888. ⟨10.1016/j.csbj.2021.03.031⟩
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 1874-1888 (2021)

Graphical abstract
Globin-coupled sensors (GCS) usually consist of three domains: a sensor/globin, a linker, and a transmitter domain. The globin domain (GD), activated by ligand binding and/or redox change, induces an intramolecular signal tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73706640625aa1c4d5a12de7e52b01b4
https://doi.org/10.1016/j.csbj.2021.03.031

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The Sigma-1 receptor is an ER-localized type II membrane protein

Autor: Marina Shenkman, Neeraj Sharma, Nir Ben-Tal, Gerardo Z. Lederkremer, Chaitanya Patel, Amit Kessel

Publikováno v: The Journal of Biological Chemistry

The Sigma-1 receptor (S1R) is a transmembrane protein with important roles in cellular homeostasis in normal physiology and in disease. Especially in neurodegenerative diseases, S1R activation has been shown to provide neuroprotection by modulating c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8ce8865974da911ce3941dccddc42b
https://pubmed.ncbi.nlm.nih.gov/34648767

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Proteomic Analysis of Trichomonas vaginalis Phagolysosome, Lysosomal Targeting, and Unconventional Secretion of Cysteine Peptidases

Autor: Nadine, Zimmann, Petr, Rada, Vojtěch, Žárský, Tamara, Smutná, Kristína, Záhonová, Joel, Dacks, Karel, Harant, Ivan, Hrdý, Jan, Tachezy

Publikováno v: Molecular & Cellular Proteomics : MCP

The lysosome represents a central degradative compartment of eukaryote cells, yet little is known about the biogenesis and function of this organelle in parasitic protists. Whereas the mannose 6-phosphate (M6P)-dependent system is dominant for lysoso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d8b7a8dffd0ed0f52289b27ed2884830
https://pubmed.ncbi.nlm.nih.gov/34763061

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Structural basis of NF-κB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains

Autor: Zhen Li, Xianbin Tian, Lilian Kisiswa, Ajeena Ramanujan, Ning Zhang, Carlos F. Ibáñez, Wensu Yuan, Zhi Lin, Eunice Weiling Sim

Publikováno v: Zhang, N, Kisiswa, L, Ramanujan, A, Li, Z, Sim, E W, Tian, X, Yuan, W, Ibáñez, C F & Lin, Z 2021, ' Structural basis of NF-κB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains ', Journal of Biological Chemistry, vol. 297, no. 2, 100916 . https://doi.org/10.1016/j.jbc.2021.100916
The Journal of Biological Chemistry

The p75 neurotrophin receptor (p75NTR) is a critical mediator of neuronal death and tissue remodeling and has been implicated in various neurodegenerative diseases and cancers. The death domain (DD) of p75NTR is an intracellular signaling hub and has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0bbd2cb844bf0783353c7d641f4ec8
https://pure.au.dk/portal/da/publications/structural-basis-of-nfb-signaling-by-the-p75-neurotrophin-receptor-interaction-with-adaptor-protein-tradd-through-their-respective-death-domains(955eafca-a0a5-442c-8b0e-8eceffee7ca1).html

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Structure and function of the vacuolar Ccc1/VIT1 family of iron transporters and its regulation in fungi

Autor: Sergi Puig, María Teresa Martínez-Pastor, David Peris, Raquel Sorribes-Dauden

Publikováno v: Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 3712-3722 (2020)
Sorribes-Dauden, Raquel Peris Navarro, David Martínez Pastor, María Teresa Puig Todolí, Sergi 2020 Structure and function of the vacuolar Ccc1/VIT1 family of iron transporters and its regulation in fungi Computational And Structural Biotechnology Journal 18 3712 3722
RODERIC: Repositorio Institucional de la Universitat de Valéncia
Universitat de València
Digital.CSIC. Repositorio Institucional del CSIC
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RODERIC. Repositorio Institucional de la Universitat de Valéncia
Computational and Structural Biotechnology Journal

Iron is an essential micronutrient for most living beings since it participates as a redox active cofactor in many biological processes including cellular respiration, lipid biosynthesis, DNA replication and repair, and ribosome biogenesis and recycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19a7472616cb2fcad1e8ec6dc6e5551
http://www.sciencedirect.com/science/article/pii/S2001037020304669

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Identification of a clinical compound losmapimod that blocks Lassa virus entry

Autor: Feihu Yan, Ying Guo, Logan Banadyga, Shihua He, Wenjun Zhu, Guo Jiamei, Xiangguo Qiu, Qing Chen, Tang Ke, Xiaoyu Zhang

Publikováno v: Antiviral Research

Lassa virus (LASV) causes Lassa hemorrhagic fever in humans and poses a significant threat to public health in West Africa. Current therapeutic treatments for Lassa fever are limited, making the development of novel countermeasures an urgent priority

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7959b5c1d1ee0e1523e05bbdcee331bf
https://doi.org/10.1016/j.antiviral.2019.03.014

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Interaction between the transmembrane domains of neurotrophin receptors p75 and TrkA mediates their reciprocal activation

Autor: Fozia Ahmed, Kalina Hristova, Sergey A. Goncharuk, Andrea Soler-Lopez, Marçal Vilar, Kirill D. Nadezhdin, Taylor P. Light, Konstantin S. Mineev, Alexander S. Arseniev, María Luisa Franco

Publikováno v: The Journal of Biological Chemistry
Digital.CSIC. Repositorio Institucional del CSIC
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12 páginas, 6 figuras. CSs fromTrkA-TMD and p75-TMD are deposited in the Biological Magnetic Resonance Data Bank with accession number 25872for TrkA-TMD and 19673 for p75-TMD.
The neurotrophin receptors p75 and tyrosine protein kinase receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85af64fd4aa64a56d2d99d9492ad5817
http://europepmc.org/articles/PMC8327350

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Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site

Autor: Marijke Brams, Diletta Pasini, Akshay Sridhar, Chris Ulens, Sarah C. R. Lummis, Kumiko Kambara, Rebecca J. Howard, Aujan Mehregan, Erik Lindahl, Daniel Bertrand

Publikováno v: The Journal of Biological Chemistry
Journal of Biological Chemistry

Pentameric ligand-gated ion channels (pLGICs) are crucial mediators of electrochemical signal transduction in various organisms from bacteria to humans. Lipids play an important role in regulating pLGIC function, yet the structural bases for specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b160ea3186d551ffde4ccf17635eb8
http://europepmc.org/articles/PMC8327344

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