Zobrazeno 1 - 10
of 23
pro vyhledávání: '"TM, transmembrane (domain)"'
Publikováno v:
Translational Oncology, Vol 14, Iss 7, Pp 101097-(2021)
Translational Oncology
Translational Oncology
A recent study in Scientific Reports identified glypican-3 (GPC3) as a novel extracellular interacting protein for FAT1 in hepato-cellular carcinoma (HCC) cells. FAT1 is a large transmembrane atypical cadherin with limited knowledge existing about it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d16b235ca31683abbf42554ed5af0f
http://www.sciencedirect.com/science/article/pii/S1936523321000899
http://www.sciencedirect.com/science/article/pii/S1936523321000899
Publikováno v:
Gene Reports
SARS-CoV-2 is mutating and creating divergent variants by altering the composition of essential constituent proteins. Pharmacologically, it is crucial to understand the diverse mechanism of mutations for stable vaccine or anti-viral drug design. Our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd2e5948552ae82510808cd1a09329d
http://europepmc.org/articles/PMC7893251
http://europepmc.org/articles/PMC7893251
Publikováno v:
The Journal of Biological Chemistry
The envelopment of hepatitis C virus (HCV) is believed to occur primarily in the endoplasmic reticulum (ER)-associated membrane, and the translocation of viral Core protein from lipid droplets (LDs) to the ER is essential for the envelopment of viral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c1466e2fb68edfd93f95f5ad023564
http://europepmc.org/articles/PMC7949066
http://europepmc.org/articles/PMC7949066
Publikováno v:
Developmental and Comparative Immunology
C-Type Lectin Receptors (CTLR) are involved in the activation of innate and adaptative immune responses. Among these receptors, the Dendritic Cell-Specific ICAM-3-Grabbing nonintegrin (DC-SIGN/CD209) has become a hot topic due to its ability to bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e67d431a312c5f9eb6a0edee725fd11
https://pubmed.ncbi.nlm.nih.gov/32739503
https://pubmed.ncbi.nlm.nih.gov/32739503
Autor:
Jens Meiler, Hope Woods, Jonathan P. Schlebach, Beata Jastrzebska, Charles P. Kuntz, Joseph T. Ortega, Francis J. Roushar, Victoria Most, Andrew G. McKee
Publikováno v:
The Journal of Biological Chemistry
Membrane protein variants with diminished conformational stability often exhibit enhanced cellular expression at reduced growth temperatures. The expression of "temperature-sensitive" variants is also typically sensitive to corrector molecules that b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9142578362bd4d540ceabc59ad0ffcb2
https://doi.org/10.1016/j.jbc.2021.101359
https://doi.org/10.1016/j.jbc.2021.101359
Autor:
Dana Khdr Sabir
Publikováno v:
Gene Reports
The ongoing pandemic of COVID-19 caused by the SARS-COV2 virus has triggered millions of deaths around the globe. Emerging several variants of the virus with increased transmissibility, the severity of disease, and the ability of the virus to escape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9501a6bfebfbfa7e7193206f1457b380
http://europepmc.org/articles/PMC8568320
http://europepmc.org/articles/PMC8568320
Publikováno v:
Neuropharmacology
G protein-coupled receptors (GPCRs) have been classically described as monomeric entities that function by binding in a 1:1 stoichiometric ratio to both ligand and downstream signalling proteins. However, in recent years, a growing number of studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e681f8b2af627c7275cbc4231d35f3fe
http://europepmc.org/articles/PMC6078712
http://europepmc.org/articles/PMC6078712
Autor:
Rocco Pizzarelli, Andrea Barberis, Antonino Cattaneo, Enrico Cherubini, Enrica Maria Petrini, Marilena Griguoli, Paola Zacchi
Publikováno v:
Neuroscience
To be highly reliable, synaptic transmission needs postsynaptic receptors (Rs) in precise apposition to the presynaptic release sites. At inhibitory synapses, the postsynaptic protein gephyrin self-assembles to form a scaffold that anchors glycine an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90608b4dcd3ea52993f032731e6b4192
https://hdl.handle.net/11384/126845
https://hdl.handle.net/11384/126845
Autor:
Lauren E. Heusinkveld, Jaclyn M. Kline, Sergio M. Pontejo, Eleanor Taranto, Kyoungin Cho, Isabel J. Hsu, Jaspal S. Khillan, Philip M. Murphy, Alessandra G. Tomasi, Clare B. Martin
Publikováno v:
The Journal of Biological Chemistry
Mouse Ccr1l1 (Ccr1-like 1) encodes an orphan G-protein-coupled receptor (GPCR) with the highest homology to the inflammatory and highly promiscuous chemokine receptors Ccr1 and Ccr3 (70 and 50% amino acid identity, respectively). Ccr1l1 was first clo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d8eb04029dd1ca8a1ca05532d4c0ca
https://doi.org/10.1016/j.jbc.2021.100373
https://doi.org/10.1016/j.jbc.2021.100373
Autor:
Celine Valant, Patrick M. Sexton, Elham Khajehali, Peter J. Scammells, Manuela Jörg, Craig W. Lindsley, Arthur Christopoulos, Andrew B. Tobin, P. Jeffrey Conn
Publikováno v:
Biochemical Pharmacology
Graphical abstract
Subtype-selective allosteric modulation of the M1 muscarinic acetylcholine (ACh) receptor (M1 mAChR) is an attractive approach for the treatment of numerous disorders, including cognitive deficits. The discovery of benzyl quin
Subtype-selective allosteric modulation of the M1 muscarinic acetylcholine (ACh) receptor (M1 mAChR) is an attractive approach for the treatment of numerous disorders, including cognitive deficits. The discovery of benzyl quin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9825fb21ad2045775ecf4d26ab83b0c2
https://eprints.gla.ac.uk/163141/1/163141.pdf
https://eprints.gla.ac.uk/163141/1/163141.pdf