A scaffold vaccine to promote tumor antigen cross-presentation via sustained toll-like receptor-2 (TLR2) activation

Autor: Daping Xie, Congwei Han, Chonghao Chen, Zhencheng Liao, Senio Campos de Souza, Yiming Niu, João F. Mano, Lei Dong, Chunming Wang

Publikováno v: Bioactive Materials, Vol 37, Iss , Pp 315-330 (2024)

Cancer vaccination holds great promise for cancer treatment, but its effectiveness is hindered by suboptimal activation of CD8+ cytotoxic T lymphocytes, which are potent effectors to mediate anti-tumor immune responses. A possible solution is to swit

Externí odkaz: https://doaj.org/article/63cce374d08d4b5183ab56a352bb148e

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TGFβ primes alveolar-like macrophages to induce type I IFN following TLR2 activation.

Autor: Thomas SM; Department of Microbiology, Genetics, and Immunology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI., Ankley LM; Department of Microbiology, Genetics, and Immunology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI., Conner KN; Department of Microbiology, Genetics, and Immunology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI., Rapp AW; Department of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH., McGee AP; Department of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH., LeSage F; Department of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH., Tanner CD; Department of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH., Vielma TE; Department of Microbiology, Genetics, and Immunology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI., Scheeres EC; Department of Microbiology, Genetics, and Immunology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI., Obar JJ; Department of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH., Olive AJ; Department of Microbiology, Genetics, and Immunology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 08. Date of Electronic Publication: 2024 Sep 08.

A scaffold vaccine to promote tumor antigen cross-presentation viasustained toll-like receptor-2 (TLR2) activation

Autor: Xie, Daping, Han, Congwei, Chen, Chonghao, Liao, Zhencheng, Campos de Souza, Senio, Niu, Yiming, Mano, João F., Dong, Lei, Wang, Chunming

Publikováno v: Bioactive Materials; July 2024, Vol. 37 Issue: 1 p315-330, 16p

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