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TLE4 Is a Critical Mediator of Osteoblast and Runx2-Dependent Bone Development

Autor: Thomas H. Shin, Evangelos Theodorou, Carl Holland, Rae’e Yamin, Cathleen L. Raggio, Philip F. Giampietro, David A. Sweetser

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Healthy bone homeostasis hinges upon a delicate balance and regulation of multiple processes that contribute to bone development and metabolism. While examining hematopoietic regulation by Tle4, we have uncovered a previously unappreciated role of Tl

Externí odkaz: https://doaj.org/article/9718a56ab2174675a2fafe5f2bd62eb3

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Pathway and network analysis of more than 2500 whole cancer genomes

Autor: Reyna M. A., Haan D., Paczkowska M., Verbeke L. P. C., Vazquez M., Kahraman A., Pulido-Tamayo S., Barenboim J., Wadi L., Dhingra P., Shrestha R., Getz G., Lawrence M. S., Pedersen J. S., Rubin M. A., Wheeler D. A., Brunak S., Izarzugaza J. M. G., Khurana E., Marchal K., von Mering C., Sahinalp S. C., Valencia A., Abascal F., Amin S. B., Bader G. D., Bandopadhayay P., Beroukhim R., Bertl J., Boroevich K. A., Busanovich J., Campbell P. J., Carlevaro-Fita J., Chakravarty D., Chan C. W. Y., Chen K., Choi J. K., Deu-Pons J., Diamanti K., Feuerbach L., Fink J. L., Fonseca N. A., Frigola J., Gambacorti Passerini C., Garsed D. W., Gerstein M., Guo Q., Gut I. G., Hamilton M. P., Haradhvala N. J., Harmanci A. O., Helmy M., Herrmann C., Hess J. M., Hobolth A., Hodzic E., Hong C., Hornshoj H., Isaev K., Johnson R., Johnson T. A., Juul M., Juul R. I., Kahles A., Kellis M., Kim J., Kim J. K., Kim Y., Komorowski J., Korbel J. O., Kumar S., Lanzos A., Larsson E., Lee D., Lehmann K. -V., Li S., Li X., Lin Z., Liu E. M., Lochovsky L., Lou S., Madsen T., Martincorena I., Martinez-Fundichely A., Maruvka Y. E., McGillivray P. D., Meyerson W., Muinos F., Mularoni L., Nakagawa H., Nielsen M. M., Park K., Pons T., Reyes-Salazar I., Rheinbay E., Rubio-Perez C., Saksena G., Salichos L., Sander C., Schumacher S. E., Shackleton M., Shapira O., Shen C., Shuai S., Sidiropoulos N., Sieverling L., Sinnott-Armstrong N., Stein L. D., Tamborero D., Tiao G., Tsunoda T., Umer H. M., Uuskula-Reimand L., Wadelius C., Wang J., Warrell J., Waszak S. M., Weischenfeldt J., Wu G., Yu J., Zhang J., Zhang X., Zhang Y., Zhao Z., Zou L., Reimand J., Stuart J. M., Raphael B. J.

Publikováno v: Reyna, Matthew A; Haan, David; Paczkowska, Marta; Verbeke, Lieven P C; Vazquez, Miguel; Kahraman, Abdullah; Pulido-Tamayo, Sergio; Barenboim, Jonathan; Wadi, Lina; Dhingra, Priyanka; Shrestha, Raunak; Getz, Gad; Lawrence, Michael S; Pedersen, Jakob Skou; Rubin, Mark Andrew; Wheeler, David A; Brunak, Søren; Izarzugaza, Jose M G; Khurana, Ekta; Marchal, Kathleen; ... (2020). Pathway and network analysis of more than 2500 whole cancer genomes. Nature communications, 11(1), p. 729. Nature Publishing Group 10.1038/s41467-020-14367-0
Nature Communications, 11, 1
Nature communications, vol 11, iss 1
Reyna, M A, Haan, D, Paczkowska, M, Verbeke, L P C, Vazquez, M, Kahraman, A, Pulido-Tamayo, S, Barenboim, J, Wadi, L, Dhingra, P, Shrestha, R, Getz, G, Lawrence, M S, Pedersen, J S, Rubin, M A, Wheeler, D A, Brunak, S, Izarzugaza, J M G, Khurana, E, Marchal, K, von Mering, C, Sahinalp, S C, Valencia, A, PCAWG Drivers and Functional Interpretation Working Group, Reimand, J, Stewart, J, Raphael, B & PCAWG Consortium 2020, ' Pathway and network analysis of more than 2500 whole cancer genomes ', Nature Communications, vol. 11, no. 1, 729 . https://doi.org/10.1038/s41467-020-14367-0
NATURE COMMUNICATIONS
Nature Communications
Nature Communications, 11 (1)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, 11
Reyna, M A, Haan, D, Paczkowska, M, Verbeke, L P C, Vazquez, M, Kahraman, A, Pulido-Tamayo, S, Barenboim, J, Wadi, L, Dhingra, P, Shrestha, R, Getz, G, Lawrence, M S, Pedersen, J S, Rubin, M A, Wheeler, D A, Brunak, S, Izarzugaza, J M G, Khurana, E, Marchal, K, von Mering, C, Sahinalp, S C, Valencia, A, Abascal, F, Amin, S B, Bader, G D, Bandopadhayay, P, Beroukhim, R, Bertl, J, Boroevich, K A, Busanovich, J, Campbell, P J, Carlevaro-Fita, J, Chakravarty, D, Chan, C W Y, Chen, K, Choi, J K, Deu-Pons, J, Diamanti, K, Feuerbach, L, Fink, J L, Fonseca, N A, Frigola, J, Gambacorti-Passerini, C, Garsed, D W, Gerstein, M, Larsson, E, Nielsen, M M, Sidiropoulos, N, Weischenfeldt, J, PCAWG Drivers and Functional Interpretation Working Group & PCAWG Consortium 2020, ' Pathway and network analysis of more than 2500 whole cancer genomes ', Nature Communications, vol. 11, no. 1, 729, pp. 1-17 . https://doi.org/10.1038/s41467-020-14367-0
Reyna, M A, Haan, D, Paczkowska, M, Verbeke, L P C, Vazquez, M, Kahraman, A, Pulido-Tamayo, S, Barenboim, J, Wadi, L, Dhingra, P, Shrestha, R, Getz, G, Lawrence, M S, Pedersen, J S, Rubin, M A, Wheeler, D A, Brunak, S, Izarzugaza, J M G, Khurana, E, Marchal, K, von Mering, C, Sahinalp, S C, Valencia, A, Reimand, J, Stuart, J M & Raphael, B J 2020, ' Pathway and network analysis of more than 2500 whole cancer genomes ', Nature Communications, vol. 11, no. 1, 729 . https://doi.org/10.1038/s41467-020-14367-0

The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade. However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding mutations, most notably TERT pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab9bdc4055f3e9c174d4c3aed78c672
https://boris.unibe.ch/146112/1/41467_2020_Article_14367.pdf