Zobrazeno 1 - 10
of 121
pro vyhledávání: '"TKIs resistance"'
Autor:
Shanshan Huang, Yaling Long, Yuan Gao, Wanling Lin, Lei Wang, Jizong Jiang, Xun Yuan, Yuan Chen, Peng Zhang, Qian Chu
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-14 (2024)
Abstract Background Aberrant activation of mesenchymal epithelial transition (MET) has been considered to mediate primary and acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant non-small ce
Externí odkaz:
https://doaj.org/article/072706ab2ba84703ae0b7712ea79cc75
Autor:
Diao Yunlian, Huang Shibo, Liu Fangpeng, Liao Shu, Guan Chenxi, Xiong Xiaojian, Zhang Ping, Li Junyao, Zhang Wei, Ying Ying
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 1549-1560 (2024)
Acquired resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) represents a primary cause of treatment failure in non-small cell lung cancer (NSCLC) patients. Chemokine (C-C motif) ligand 2 (CCL2) is recently found to play a pivotal role in deter
Externí odkaz:
https://doaj.org/article/2104750fcc1545be8f0a691301454a65
Publikováno v:
Frontiers in Chemistry, Vol 11 (2024)
Glioblastoma multiforme (GBM) is a highly aggressive malignant primary tumor in the central nervous system. Despite extensive efforts in radiotherapy, chemotherapy, and neurosurgery, there remains an inadequate level of improvement in treatment outco
Externí odkaz:
https://doaj.org/article/70e826bab88d43609369fa0a07aa7d85
Publikováno v:
Chinese Journal of Lung Cancer, Vol 25, Iss 8, Pp 601-608 (2022)
The follow-up treatment of patients with advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutation after drug resistance to EGFR-tyrosine kinase inhibitors (TKIs) have become a hotspot and difficulty at present
Externí odkaz:
https://doaj.org/article/07ce93ce70d54bcab9b5e595703d82da
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract The tumor microenvironment is a dynamic cellular milieu that interacts with cancer cells and promotes tumor progression and metastasis. However, the specific mechanisms by which the tumor microenvironment impacts cancer cells’ behaviors re
Externí odkaz:
https://doaj.org/article/670a69c5bac64b47ac386195cd00e2dd
Autor:
Zhenzhen Pan, Kai Wang, Xiniao Wang, Zhirong Jia, Yuqi Yang, Yalei Duan, Lianzhan Huang, Zhuo-Xun Wu, Jian-ye Zhang, Xuansheng Ding
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-17 (2022)
Abstract Background The use of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) brings remarkable benefits for the survival of patients with advanced NSCLC harboring EGFR mutations. Unfortunately, acquired resistance seems to b
Externí odkaz:
https://doaj.org/article/d60880850d5b4603bc028aaf3864412d
Autor:
Huibin Song, Dongcheng Liu, Lingwei Wang, Kaisheng Liu, Chen Chen, Le Wang, Yi Ren, Bing Ju, Fuhua Zhong, Xingyu Jiang, Guangsuo Wang, Zhe-Sheng Chen, Chang Zou
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-20 (2022)
Abstract Background Identification of potential novel targets for reversing resistance to Epidermal Growth Factor Receptor (EGFR)-tyrosine kinase inhibitors (EGFR-TKIs) holds great promise for the treatment of relapsed lung adenocarcinoma (LUAD). In
Externí odkaz:
https://doaj.org/article/849d19aab0f44f8ab19ba4a76e68143c
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Shunli Peng, Rong Wang, Xiaojuan Zhang, Yueyun Ma, Longhui Zhong, Ke Li, Akihiro Nishiyama, Sachiko Arai, Seiji Yano, Wei Wang
Publikováno v:
Molecular Cancer, Vol 18, Iss 1, Pp 1-14 (2019)
Abstract Background The ATLANTIC trial reported that higher PD-L1 expression in tumors was involved in a higher objective response in patients with EGFR + /ALK + non-small cell lung cancer (NSCLC), indicating the possibility of anti-PD-1/PD-L1 therap
Externí odkaz:
https://doaj.org/article/d003dc1a9b6d4f60a1547e423fc09596