Mutation in the Kinase Domain Alters the VEGFR2 Membrane Dynamics

Autor: Michela Corsini, Cosetta Ravelli, Elisabetta Grillo, Mattia Domenichini, Stefania Mitola

Publikováno v: Cells, Vol 13, Iss 16, p 1346 (2024)

Background: Recently, the substitution R1051Q in VEGFR2 has been described as a cancer-associated “gain of function” mutation. VEGFR2R1051Q phosphorylation is ligand-independent and enhances the activation of intracellular pathways and cell growt

Externí odkaz: https://doaj.org/article/3eed6bccbdeb49e7a956c08d9041cf88

HCC Heterogeneity: Molecular Pathogenesis and Clinical Implications

Autor: Fransvea, Emilia, Paradiso, Angelo, Antonaci, Salvatore, Giannelli, Gianluigi

Publikováno v: Cellular Oncology, Vol 31, Iss 3, Pp 227-233 (2009)
Cellular Oncology : the Official Journal of the International Society for Cellular Oncology

Background: Hepatocellular carcinoma (HCC) poses a major challenge because of the extreme variability of the clinical outcome, which makes it difficult to properly stage the disease and thereby estimate the prognosis. There is growing evidence that t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a8d39936c81ffc930e98f75758deae