Phase 1/2a study of AZD5305, a novel poly(adenosine diphosphate ribose) polymerase (PARP) 1-selective inhibitor in combination with new hormonal agents (NHAs) in patients (pts) with metastatic prostate cancer (mPC)

Autor: Arun Azad, Mark Voskoboynik, Ana Filipa Palma dos Reis, Anthony M. Joshua, Andrew James Weickhardt, Robert J. Jones, Pasquale Rescigno, Ben Tran, Caroline Kennedy, Spiros Linardopoulos, Ganesh Moorthy, TJ Zhou, Jessica S Brown, Edit Lukacs, Richard Francis, Andrew Hudson

Publikováno v: Journal of Clinical Oncology. 41:TPS296-TPS296

TPS296 Background: AZD5305 is a potent and selective oral PARP inhibitor (PARPi) that specifically targets and traps PARP1, in contrast to approved PARPis which target both PARP1 and PARP2. Preclinical data suggest that PARP1 inhibition confers antip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1f98df56d18636c48d468c52af05a8f
https://doi.org/10.1200/jco.2023.41.6_suppl.tps296

A Computational Study on Effects of PID Temperature Target and RF Frequency for PID-Controlled Nonablative RF Cosmetic Systems.

Autor: Wang LX; School of Health Science and Engineering, University of Shanghai for Science and Technology, Yangpu, Shanghai, China., Kong XY; School of Health Science and Engineering, University of Shanghai for Science and Technology, Yangpu, Shanghai, China., Zhou TJ; Dermatological Department, Shanghai Jiangcheng Dermatology Hospital, Shanghai, China.

Publikováno v: Lasers in surgery and medicine [Lasers Surg Med] 2024 Dec; Vol. 56 (10), pp. 865-879. Date of Electronic Publication: 2024 Nov 04.

Improving agreement in assessing subtrochanteric fracture healing among orthopedic surgeons using the Radiographic Union Score for Hip (RUSH).

Autor: Zhou TJ; Department of Orthopedic Surgery, Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, P.R. China. zhou.tianjian@szhospital.com.; The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510405, P.R. China. zhou.tianjian@szhospital.com., Jiang S; Department of Orthopedic Surgery, Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, P.R. China., Ren JK; Department of Orthopedic Surgery, Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, P.R. China., Zhang X; Department of Orthopedic Surgery, Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, P.R. China., Liu WX; Department of Orthopedic Surgery, Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, P.R. China., Yan P; Department of Orthopedic Surgery, Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, P.R. China., Li JW; Department of Orthopedic Surgery, Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, P.R. China., Zeng T; Department of Orthopedic Surgery, Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, P.R. China., Xu ZS; Department of Orthopedic Surgery, Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, P.R. China. xuzhongshi@mail.sustech.edu.cn.

Publikováno v: BMC musculoskeletal disorders [BMC Musculoskelet Disord] 2024 Oct 09; Vol. 25 (1), pp. 798. Date of Electronic Publication: 2024 Oct 09.

Glutathione depletion and dihydroorotate dehydrogenase inhibition actuated ferroptosis-augment to surmount triple-negative breast cancer.

Autor: Zhou TJ; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, PR China., Zhang MM; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, PR China., Liu DM; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, PR China., Huang LL; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, PR China., Yu HQ; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, PR China., Wang Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, PR China., Xing L; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, PR China. Electronic address: xinglei6xl@163.com., Jiang HL; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, PR China; College of Pharmacy, Yanbian University, Yanji, 133002, PR China; NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, China Pharmaceutical University, 210009, PR China. Electronic address: jianghulin3@163.com.

Publikováno v: Biomaterials [Biomaterials] 2024 Mar; Vol. 305, pp. 122447. Date of Electronic Publication: 2023 Dec 26.

Engineered stem cell-based strategy: A new paradigm of next-generation stem cell product in regenerative medicine.

Autor: Han H; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China., Chen BT; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China., Liu Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China., Wang Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China., Xing L; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China; College of Pharmacy, Yanbian University, Yanji 133002, China., Wang H; Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China., Zhou TJ; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China. Electronic address: zhoutj1993@163.com., Jiang HL; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China; College of Pharmacy, Yanbian University, Yanji 133002, China. Electronic address: jianghulin3@163.com.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2024 Jan; Vol. 365, pp. 981-1003. Date of Electronic Publication: 2023 Dec 21.