Zobrazeno 1 - 10
of 43
pro vyhledávání: '"TJ Kunicki"'
Publikováno v:
Blood. 88:887-899
The sequence beta (3)203–228 is involved, in a yet undetermined manner, in alpha IIb beta 3 function. We now show that murine monoclonal antibody (MoAb) AP6, specific for beta (3)211–221, binds to alpha IIb beta 3 on adenosine diphosphate (ADP)-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58ef8a943023d6273e2104c7773a23bc
https://doi.org/10.1182/blood.v88.3.887.bloodjournal883887
https://doi.org/10.1182/blood.v88.3.887.bloodjournal883887
Publikováno v:
Europe PubMed Central
We have characterized a murine IgG monoclonal antibody, OP-G2, specific for platelet glycoprotein (GP) IIb-IIIa (alpha IIb beta 3). OP-G2 Fab fragments inhibit fibrinogen-mediated platelet aggregation and competitively inhibit adenosine diphosphate-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3110201fe1528c19f5325b799542414f
https://doi.org/10.1182/blood.v79.9.2303.bloodjournal7992303
https://doi.org/10.1182/blood.v79.9.2303.bloodjournal7992303
Publikováno v:
Europe PubMed Central
Activation of the platelet integrin alpha(IIb)beta3, an essential step in platelet aggregation, is regulated by intracellular signal pathways (inside-out signaling). In this study, we characterize a 35-year-old Japanese female, HM, with a life-long h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f8ec70866533043f5514d091a8656e19
https://pubmed.ncbi.nlm.nih.gov/9843164
https://pubmed.ncbi.nlm.nih.gov/9843164
Publikováno v:
Blood. 84(4)
One proposed ligand binding site on platelet integrin alpha IIb beta 3 is the region of the beta 3 subunit encompassing amino acids 211–221. However, we recently showed that synthetic peptides corresponding to amino acids 211–221 inhibit fibrinog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592cb8a8ab99df42889591c0a758d561
https://pubmed.ncbi.nlm.nih.gov/8049427
https://pubmed.ncbi.nlm.nih.gov/8049427
Publikováno v:
Blood. 83(11)
The relative antithrombotic effectiveness of targeting glycoprotein (GP) Ib-dependent versus GPIIb-IIIa-dependent platelet interactions has been determined in baboons by measuring thrombus formation after infusing comparable antihemostatic doses of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72d55ecd0b1cdc9d7dfd1a09db0d142
https://pubmed.ncbi.nlm.nih.gov/8193356
https://pubmed.ncbi.nlm.nih.gov/8193356
Publikováno v:
Europe PubMed Central
In agreement with previous studies, we observed that incubation of washed human platelets with EDTA at 37 degrees C for short periods caused an irreversible loss of their aggregation response to adenosine diphosphate and markedly diminished their cap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdbb85b7a75a4ed743e16948d5024b74
https://doi.org/10.1182/blood.v67.3.604.bloodjournal673604
https://doi.org/10.1182/blood.v67.3.604.bloodjournal673604
Publikováno v:
Europe PubMed Central
A murine monoclonal antibody, designated AP-2, reacts specifically with the complex formed by human platelet membrane glycoproteins IIb and IIIa, but does not react at all with the individual glycoproteins. Purified AP-2 covalently coupled to Sepharo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::64d0de739dec83c1817f11eb97d0afdc
https://pubmed.ncbi.nlm.nih.gov/6226659
https://pubmed.ncbi.nlm.nih.gov/6226659
Publikováno v:
Blood. 59(4)
The gray platelet syndrome is a rare inherited platelet disorder characterized by the absence of alp ha-granules as observed by electron microscopy. Analysis of the glycoprotein composition of the platelets of 2 such patients by SDS-polyacrylamide ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea95b12a3e10440809de7bf80e66811
https://pubmed.ncbi.nlm.nih.gov/6460535
https://pubmed.ncbi.nlm.nih.gov/6460535
Publikováno v:
Europe PubMed Central
A number of recent reports have described murine monoclonal antibodies that react specifically with the complex formed by human platelet membrane glycoproteins (GP) IIb and IIIa. We show that the IgG L, a previously described human alloantibody isola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c437290649dc6206b3dd5e5c5be812f
https://pubmed.ncbi.nlm.nih.gov/6208954
https://pubmed.ncbi.nlm.nih.gov/6208954
Publikováno v:
Blood. 55(1)
To evaluate the possibility that changes in lipid composition might be related to the functional lesion that develops when platelets are stored as concentrates for several days, we measured lipid constituents of platelets in freshly prepared concentr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e90b8e288d3ffa7140a94b7935fbb67
https://pubmed.ncbi.nlm.nih.gov/7350932
https://pubmed.ncbi.nlm.nih.gov/7350932