Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis

Autor: AG Bajpayee, RE De la Vega, M Scheu, NH Varady, IA Yannatos, LA Brown, Y Krishnan, TJ Fitzsimons, P Bhattacharya, EH Frank, AJ Grodzinsky, RM Porter

Publikováno v: European Cells & Materials, Vol 34, Pp 341-364 (2017)

Disease-modifying osteoarthritis drugs (DMOADs) should reach their intra-tissue target sites at optimal doses for clinical efficacy. The dense, negatively charged matrix of cartilage poses a major hindrance to the transport of potential therapeutics.

Externí odkaz: https://doaj.org/article/0ac6005b5acd437292d1a78aabac3750

Pharmacokinetics and pharmacodynamics of verapamil in combination with atenolol, metoprolol and propranolol

Autor: TJ Fitzsimons, Dw Holt, Atholl Johnston, SJ Warrington

Publikováno v: British journal of clinical pharmacology. 17

Treatment of angina pectoris with beta-adrenoceptor antagonists and verapamil in combination is effective and increasingly common. The study reported here was designed to show whether the pharmacokinetics of verapamil are influenced by concurrent tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580b554aa8cbba9fb4b66993027b5ca4
https://pubmed.ncbi.nlm.nih.gov/6146339

Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis.

Autor: Bajpayee AG, De la Vega RE, Scheu M, Varady NH, Yannatos IA, Brown LA, Krishnan Y, Fitzsimons TJ, Bhattacharya P, Frank EH, Grodzinsky AJ, Porter RM; University of Arkansas for Medical Sciences, Division of Endocrinology and Metabolism, 4301 W. Markham Street, Mail Slot #587, Little Rock, AR 72205. rmporter@uams.edu.

Publikováno v: European cells & materials [Eur Cell Mater] 2017 Dec 05; Vol. 34, pp. 341-364. Date of Electronic Publication: 2017 Dec 05.

Comparison of once daily atenolol, nitrendipine and their combination in mild to moderate essential hypertension.

Autor: Maclean D; University Department of Clinical Pharmacology, Ninewells Hospital, Dundee., Mitchell ET, Lewis R, Irvine N, McLay JS, McEwen J, Coulson RR, Slater ND, Fitzsimons TJ, McDevitt DG

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 1990 Apr; Vol. 29 (4), pp. 455-63.

Calcium antagonists: a review of the recent comparative trials.

Autor: Fitzsimons TJ; Imperial Chemical Industries PLC, Pharmaceuticals Division, Medical Research Department, Macclesfield, Cheshire, UK.

Publikováno v: Journal of hypertension. Supplement : official journal of the International Society of Hypertension [J Hypertens Suppl] 1987 Aug; Vol. 5 (3), pp. S11-5.