A Novel Microphysiological Colon Platform to Decipher Mechanisms Driving Human Intestinal Permeability

Autor: Rohit A. Panchakshari, Athanasia Apostolou, Cosmas Giallourakis, Galeb Abu-Ali, Antara Banerjee, Tengku Ibrahim Maulana, Raymond Luc, Gauri Kulkarni, Carolina Lucchesi, Jordan Kerns, Katia Karalis, Alexandra Dimitriou, Maria D. Paraskevopoulou, Magdalena Kasendra, Elias S. Manolakos, Lorna Ewart, Geraldine A. Hamilton, Bertram Bleck, Dimitris V. Manatakis

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1719-1741 (2021)

Background & Aims The limited availability of organoid systems that mimic the molecular signatures and architecture of human intestinal epithelium has been an impediment to allowing them to be harnessed for the development of therapeutics as well as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73f86b030301637ffe301dbedd59d97
http://europepmc.org/articles/PMC8551844

Regulation of Intestinal Epithelial Barrier and Immune Function by Activated T Cells

Autor: Kien Huu Nguyen, Alan D. Levine, Nga Thanh Le, Claire Mazahery

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 55-76 (2021)

Background & Aims Communication between T cells and the intestinal epithelium is altered in many diseases, causing T-cell activation, depletion, or recruitment, and disruption of the epithelium. We hypothesize that activation of T cells regulates epi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450cac7e7a2afdff8746af24c48114ab
https://doi.org/10.1016/j.jcmgh.2020.07.004

Loss of Claudin-3 Impairs Hepatic Metabolism, Biliary Barrier Function, and Cell Proliferation in the Murine Liver

Autor: Adolfo Odriozola, Mariana Castro Dias, Daniel Candinas, Tural Yarahmadov, Fadi Jebbawi, Mikio Furuse, Benoît Zuber, Alex Odermatt, Cristina Gómez Castellà, Urban Deutsch, Adrian Keogh, Riccardo Tombolini, Deborah Stroka, Britta Engelhardt, Daniel Sánchez-Taltavull, Felix Alexander Baier

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 745-767 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Baier, Felix Alexander; Sánchez-Taltavull, Daniel; Yarahmadov, Tural; Castellà, Cristina Gómez; Jebbawi, Fadi; Keogh, Adrian; Tombolini, Riccardo; Odriozola, Adolfo; Castro Dias, Mariana; Deutsch, Urban; Furuse, Mikio; Engelhardt, Britta; Zuber, Benoît; Odermatt, Alex; Candinas, Daniel; Keogh-Stroka, Deborah M. (2021). Loss of claudin-3 impairs hepatic metabolism, biliary barrier function and cell proliferation in the murine liver. Cellular and molecular gastroenterology and hepatology, 12(2), pp. 745-767. Elsevier 10.1016/j.jcmgh.2021.04.003

Background & Aims Tight junctions in the liver are essential to maintain the blood-biliary barrier, however, the functional contribution of individual tight junction proteins to barrier and metabolic homeostasis remains largely unexplored. Here, we d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bffc6cf475451c7410cb92d0d752071
https://doi.org/10.1016/j.jcmgh.2021.04.003

Basolateral protein Scribble binds phosphatase PP1 to establish a signaling network maintaining apicobasal polarity

Autor: Regina B. Troyanovsky, Sergey M. Troyanovsky, Rei Kato, Indrajyoti Indra, Brian J. Mitchell

Publikováno v: The Journal of Biological Chemistry

Scribble, a member of the LAP protein family, contributes to the apicobasal polarity (ABP) of epithelial cells. The LAP-unique region of these proteins, which is essential and sufficient for ABP, includes a conserved Leucine-Rich Repeat (LRR) domain.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ffc510128db201992cbbf4256e9e1dc
https://pubmed.ncbi.nlm.nih.gov/34634305

Disentangling Microbial Mediators of Malnutrition: Modeling Environmental Enteric Dysfunction

Autor: Bartelt, Luther A., Bolick, David T., Guerrant, Richard L.

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology

Environmental enteric dysfunction (EED) (also referred to as environmental enteropathy) is a subclinical chronic intestinal disorder that is an emerging contributor to early childhood malnutrition. EED is common in resource-limited settings, and is p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::60f11ea7f477d060b4b1ad0d11cd2d06
http://europepmc.org/articles/PMC6477186