Approximating the semantic space: word embedding techniques in psychiatric speech analysis

Autor: Claudio Palominos, Rui He, Karla Fröhlich, Rieke Roxanne Mülfarth, Svenja Seuffert, Iris E. Sommer, Philipp Homan, Tilo Kircher, Frederike Stein, Wolfram Hinzen

Publikováno v: Schizophrenia, Vol 10, Iss 1, Pp 1-10 (2024)

Abstract Large language models provide high-dimensional representations (embeddings) of word meaning, which allow quantifying changes in the geometry of the semantic space in mental disorders. A pattern of a more condensed (‘shrinking’) semantic

Externí odkaz: https://doaj.org/article/d3accfac69b34785bf273dddd2245430

Multivariable prediction of functional outcome after first-episode psychosis: a crossover validation approach in EUFEST and PSYSCAN

Autor: Margot I. E. Slot, Maria F. Urquijo Castro, Inge Winter - van Rossum, Hendrika H. van Hell, Dominic Dwyer, Paola Dazzan, Arija Maat, Lieuwe De Haan, Benedicto Crespo-Facorro, Birte Y. Glenthøj, Stephen M. Lawrie, Colm McDonald, Oliver Gruber, Thérèse van Amelsvoort, Celso Arango, Tilo Kircher, Barnaby Nelson, Silvana Galderisi, Mark Weiser, Gabriele Sachs, Matthias Kirschner, the PSYSCAN Consortium, W. Wolfgang Fleischhacker, Philip McGuire, Nikolaos Koutsouleris, René S. Kahn

Publikováno v: Schizophrenia, Vol 10, Iss 1, Pp 1-11 (2024)

Abstract Several multivariate prognostic models have been published to predict outcomes in patients with first episode psychosis (FEP), but it remains unclear whether those predictions generalize to independent populations. Using a subset of demograp

Externí odkaz: https://doaj.org/article/303631fe2e7a477d8b64db7b350e187d

Associations between antagonistic SNPs for neuropsychiatric disorders and human brain structure

Autor: Lydia M. Federmann, Friederike S. David, Christiane Jockwitz, Thomas W. Mühleisen, Dominique I. Pelzer, Markus M. Nöthen, Svenja Caspers, Katrin Amunts, Janik Goltermann, Till F. M. Andlauer, Frederike Stein, Katharina Brosch, Tilo Kircher, Sven Cichon, Udo Dannlowski, Lisa Sindermann, Andreas J. Forstner

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract A previously published genome-wide association study (GWAS) meta-analysis across eight neuropsychiatric disorders identified antagonistic single-nucleotide polymorphisms (SNPs) at eleven genomic loci where the same allele was protective agai

Externí odkaz: https://doaj.org/article/25076bda5a404e498012095bc8fd994f

Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm

Autor: Yuchao Jiang, Cheng Luo, Jijun Wang, Lena Palaniyappan, Xiao Chang, Shitong Xiang, Jie Zhang, Mingjun Duan, Huan Huang, Christian Gaser, Kiyotaka Nemoto, Kenichiro Miura, Ryota Hashimoto, Lars T. Westlye, Genevieve Richard, Sara Fernandez-Cabello, Nadine Parker, Ole A. Andreassen, Tilo Kircher, Igor Nenadić, Frederike Stein, Florian Thomas-Odenthal, Lea Teutenberg, Paula Usemann, Udo Dannlowski, Tim Hahn, Dominik Grotegerd, Susanne Meinert, Rebekka Lencer, Yingying Tang, Tianhong Zhang, Chunbo Li, Weihua Yue, Yuyanan Zhang, Xin Yu, Enpeng Zhou, Ching-Po Lin, Shih-Jen Tsai, Amanda L. Rodrigue, David Glahn, Godfrey Pearlson, John Blangero, Andriana Karuk, Edith Pomarol-Clotet, Raymond Salvador, Paola Fuentes-Claramonte, María Ángeles Garcia-León, Gianfranco Spalletta, Fabrizio Piras, Daniela Vecchio, Nerisa Banaj, Jingliang Cheng, Zhening Liu, Jie Yang, Ali Saffet Gonul, Ozgul Uslu, Birce Begum Burhanoglu, Aslihan Uyar Demir, Kelly Rootes-Murdy, Vince D. Calhoun, Kang Sim, Melissa Green, Yann Quidé, Young Chul Chung, Woo-Sung Kim, Scott R. Sponheim, Caroline Demro, Ian S. Ramsay, Felice Iasevoli, Andrea de Bartolomeis, Annarita Barone, Mariateresa Ciccarelli, Arturo Brunetti, Sirio Cocozza, Giuseppe Pontillo, Mario Tranfa, Min Tae M. Park, Matthias Kirschner, Foivos Georgiadis, Stefan Kaiser, Tamsyn E. Van Rheenen, Susan L. Rossell, Matthew Hughes, William Woods, Sean P. Carruthers, Philip Sumner, Elysha Ringin, Filip Spaniel, Antonin Skoch, David Tomecek, Philipp Homan, Stephanie Homan, Wolfgang Omlor, Giacomo Cecere, Dana D. Nguyen, Adrian Preda, Sophia I. Thomopoulos, Neda Jahanshad, Long-Biao Cui, Dezhong Yao, Paul M. Thompson, Jessica A. Turner, Theo G. M. van Erp, Wei Cheng, ENIGMA Schizophrenia Consortium, Jianfeng Feng, ZIB Consortium

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy su

Externí odkaz: https://doaj.org/article/76bdd81832814fb8a0f1d01e09c35de4

PsyCog: A computerised mini battery for assessing cognition in psychosis

Autor: George Gifford, Alexis E. Cullen, Sandra Vieira, Anja Searle, Robert A. McCutcheon, Gemma Modinos, William S. Stone, Emily Hird, Jennifer Barnett, Hendrika H. van Hell, Ana Catalan, Edward Millgate, Nick Taptiklis, Francesca Cormack, Margot E. Slot, Paola Dazzan, Arija Maat, Lieuwe de Haan, Benedicto Crespo Facorro, Birte Glenthøj, Stephen M. Lawrie, Colm McDonald, Oliver Gruber, Thérèse van Amelsvoort, Celso Arango, Tilo Kircher, Barnaby Nelson, Silvana Galderisi, Rodrigo A. Bressan, Jun Soo Kwon, Mark Weiser, Romina Mizrahi, Gabriele Sachs, Matthias Kirschner, Abraham Reichenberg, René Kahn, Philip McGuire

Publikováno v: Schizophrenia Research: Cognition, Vol 37, Iss , Pp 100310- (2024)

Despite the functional impact of cognitive deficit in people with psychosis, objective cognitive assessment is not typically part of routine clinical care. This is partly due to the length of traditional assessments and the need for a highly trained

Externí odkaz: https://doaj.org/article/bf74cdebd23540a998210fa727352629