Zobrazeno 1 - 2
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pro vyhledávání: '"TIR1, transport inhibitor response 1"'
Publikováno v:
The Journal of Biological Chemistry
Post-translational modification of protein by ubiquitin (Ub) alters the stability, subcellular location, or function of the target protein, thereby impacting numerous biological processes and directly contributing to myriad cellular defects or diseas
Autor:
Bulatov, Emil, Ciulli, Alessio
Publikováno v:
Biochemical Journal
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets because they confer substrate specificity on the ubiquitin system. C