Tumoral microvesicle–activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma

Autor: Meng Wang, Ting-Lin Yan, Hui Wang, Ke Liu, Lin Wang, Zheng-Jun Shang, Erhui Jiang, Qing Liu, Zhe Shao, Xiaocheng Zhou, Zhi Xu, Chun-Ming Huang, Yang Chen

Publikováno v: The FASEB Journal. 33:5690-5703

Metabolic reprogramming is a hallmark of cancer. Stromal cells could function as providers of energy metabolites for tumor cells by undergoing the "reverse Warburg effect," but the mechanism has not been fully elucidated. The interaction between the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97802b4e10c9c3a988ff1ef1e272c46
https://doi.org/10.1096/fj.201802226r

Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway

Autor: Hui Wang, Zheng-Jun Shang, Ke Liu, Ting-Lin Yan, Yang Chen, Zhe Shao, Lin Wang, Zhi Xu, Xiaocheng Zhou, Erhui Jiang, Chunming Huang

Publikováno v: Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-15 (2018)

Background Cancer-associated fibroblasts (CAFs) have been widely reported to promote tumor angiogenesis. However, the underlying mechanisms of the proangiogenic switch of CAFs remain poorly understood. This study aims to clarify the mechanisms underl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da17ab46606e14c953645e43ff0b297f
https://pubmed.ncbi.nlm.nih.gov/30285793

Autophagy Induced by Areca Nut Extract Contributes to Decreasing Cisplatin Toxicity in Oral Squamous Cell Carcinoma Cells: Roles of Reactive Oxygen Species/AMPK Signaling

Autor: Zheng-Jun Shang, Ting-Lin Yan, Zhe Shao, Zhi Xu, Xiaocheng Zhou, Erhui Jiang, Chun-Ming Huang, Meng Wang, Xiao-Ping Zhao, Ke Liu

Publikováno v: International Journal of Molecular Sciences; Volume 18; Issue 3; Pages: 524
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 3, p 524 (2017)

Chewing areca nut is closely associated with oral squamous cell carcinoma (OSCC). The current study aimed to investigate potential associations between areca nut extract (ANE) and cisplatin toxicity in OSCC cells. OSCC cells (Cal-27 and Scc-9) viabil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65bf321fcf62576c272a30bcae381f8

EphA2 silencing promotes growth, migration, and metastasis in salivary adenoid cystic carcinoma: in vitro and in vivo study

Autor: Meng, Wang, Xiao-Ping, Zhao, Zhi, Xu, Ting-Lin, Yan, Yong, Song, Kai, Song, Chun-Ming, Huang, Lin, Wang, Xiao-Cheng, Zhou, Er-Hui, Jiang, Zhe, Shao, Zheng-Jun, Shang

Publikováno v: American journal of translational research. 8(3)

EphA2 is associated with tumor growth and distant metastasis in numerous human tumors. Considering the controversial effects of EphA2 in different tumors and the lack of reports in salivary adenoid cystic carcinoma (SACC), we evaluated the effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc3beb118eccb3d23d04bb35c8200e4e
https://pubmed.ncbi.nlm.nih.gov/27186278

Membrane microvesicles as mediators for melanoma-fibroblasts communication: roles of the VCAM-1/VLA-4 axis and the ERK1/2 signal pathway

Autor: Zheng-Jun Shang, Lin Wang, Ting-Lin Yan, Ke Liu, Yong Song, Meng Wang, Xiao-Ping Zhao, Kai Song

Publikováno v: Cancer letters. 360(2)

Recent studies suggest that microvesicles (MVs) within the tumor microenvironment are emerging as potent mediators for cell-cell communication. In this study, we investigated the MV-mediated transformation of normal fibroblasts to tumor-associated fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98ac12876880f3caf3b7c90ec77e180
https://pubmed.ncbi.nlm.nih.gov/25661735