Zobrazeno 1 - 10
of 803
pro vyhledávání: '"TIMP3"'
Autor:
Allison Grenell, Charandeep Singh, Monisha Raju, Alyson Wolk, Sonal Dalvi, Geeng-Fu Jang, John S. Crabb, Courtney E. Hershberger, Kannan V. Manian, Karen Hernandez, John W. Crabb, Ruchira Singh, Jianhai Du, Bela Anand-Apte
Publikováno v:
Molecular Metabolism, Vol 88, Iss , Pp 101995- (2024)
Objectives: Mutations in Tissue Inhibitor of Metalloproteinases 3 (TIMP3) cause Sorsby's Fundus Dystrophy (SFD), a dominantly inherited, rare form of macular degeneration that results in vision loss. TIMP3 is synthesized primarily by retinal pigment
Externí odkaz:
https://doaj.org/article/b2e34dbdf5864329895d170e3ed2ee8a
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Background: Numerous studies have demonstrated a positive association between the level of tissue inhibitor of metalloproteinase 3 (TIMP3) and chronic kidney disease (CKD). Nevertheless, whether those associations reflect causal links still to be det
Externí odkaz:
https://doaj.org/article/23f14ef85ae2433f85b192d4210276be
Publikováno v:
Health Science Reports, Vol 7, Iss 2, Pp n/a-n/a (2024)
Abstract Background Thyroid cancer (TC) is a prevalent and increasingly common malignant tumor. In most cases, TC progresses slowly and runs a virtually benign course. However, challenges remain with the treatment of refractory TC, which does not res
Externí odkaz:
https://doaj.org/article/8969bc3290cb4a00951b3a142fa67d5d
Autor:
Viviana Casagrande, Stefano Menini, Chiara Internò, Giuseppe Pugliese, Massimo Federici, Rossella Menghini
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2024)
IntroductionType 1 diabetes mellitus (T1DM) development involves a complex interplay of genetic, environmental, and immunological factors. By modulating the activity of proteases and receptors, the protein tissue inhibitor of metalloproteinase 3 (TIM
Externí odkaz:
https://doaj.org/article/f6790e3fbeaf407599870b22a1def2fa
Akademický článek
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Autor:
Agne Pasvenskaite, Rasa Liutkeviciene, Greta Gedvilaite, Alvita Vilkeviciute, Vykintas Liutkevicius, Virgilijus Uloza
Publikováno v:
Discover Oncology, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Purpose Results of laryngeal squamous cell carcinoma (LSCC) treatment and the 5 year survival rate of these patients remain poor. To purify therapeutic targets, investigation of new specific and prognostic blood-based markers for LSCC develo
Externí odkaz:
https://doaj.org/article/97befb4ce2ee49aea5675665fde8796b
Autor:
M. Mazzoni, K. Todoerti, L. Agnelli, E. Minna, S. Pagliardini, T. Di Marco, M. G. Borrello, A. Neri, A. Greco
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Papillary thyroid cancer (PTC) is the most frequent thyroid tumor. The tissue inhibitor of metalloproteinase-3 (TIMP3) gene encodes a matrix metalloproteinases inhibitor that exerts a tumor suppressor role in several tumor types.
Externí odkaz:
https://doaj.org/article/40db6e6443574265a77019ea58318b27
Autor:
Haohan Liu, Yongcong Yan, Jianhong Lin, Chuanchao He, Hao Liao, Huoming Li, Zhenyu Zhou, Jie Wang, Kai Mao, Zhiyu Xiao
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 788-802 (2022)
Hepatitis B virus X protein (HBx) is considered as an oncogene in tumorigenesis and progression of hepatocellular carcinoma (HCC). In recent years, the important role of circular RNAs (circRNAs) in HCC has been increasingly demonstrated. However, the
Externí odkaz:
https://doaj.org/article/03fe314552034a99a7411dbc4933fcdf
Autor:
Yue Zhou, Tongjia Zhang, Shujie Wang, Ruixiang Yang, Zitao Jiao, Kejia Lu, Hui Li, Wei Jiang, Xiaowei Zhang
Publikováno v:
Pharmacological Research, Vol 194, Iss , Pp 106846- (2023)
Malignant proliferation and metastasis are the main causes of breast cancer death. The transcription factor high mobility group (HMG) box-containing protein 1 (HBP1) is an important tumor suppressor whose deletion or mutation is closely related to th
Externí odkaz:
https://doaj.org/article/c83f8662045e4952972059064bcac8fc
Autor:
Lingyan Fang, Takaaki Kuniya, Yujin Harada, Osamu Yasuda, Nobuyo Maeda, Yutaka Suzuki, Daichi Kawaguchi, Yukiko Gotoh
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Adult neural stem cells (NSCs) in the mouse subventricular zone (SVZ) serve as a lifelong reservoir for newborn olfactory bulb neurons. Recent studies have identified a slowly dividing subpopulation of embryonic neural stem-progenitor cells (NPCs) as
Externí odkaz:
https://doaj.org/article/c8dc16d30b4041f5b8a665c2bdd19271