Zobrazeno 1 - 10 of 439 pro vyhledávání: '"TIM/TOM complex"'
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Akademický článek
The Mitochondrial Routing of the Kv1.3 Channel
Autor: Jesusa Capera, María Navarro-Pérez, Anne Stine Moen, Ildiko Szabó, Antonio Felipe
Publikováno v: Frontiers in Oncology, Vol 12 (2022)
Voltage-gated potassium channels control neuronal excitability and cardiac action potentials. In addition, these proteins are involved in a myriad of cellular processes. The potassium channel Kv1.3 plays an essential role in the immune response media
Externí odkaz: https://doaj.org/article/c65fc6c886f04dbf98ab37409251982e
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3
Porins as helpers in mitochondrial protein translocation
Autor: Alexander Grevel, Thomas Becker
Publikováno v: Biological Chemistry. 401:699-708
Mitochondria import the vast majority of their proteins via dedicated protein machineries. The translocase of the outer membrane (TOM complex) forms the main entry site for precursor proteins that are produced on cytosolic ribosomes. Subsequently, di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9af861256b85b9dbb9127433d62fc76
https://doi.org/10.1515/hsz-2019-0438
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4
Evolution of mitochondrial protein import – lessons from trypanosomes
Autor: André Schneider
Publikováno v: Schneider, André (2020). Evolution of mitochondrial protein import – lessons from trypanosomes. Biological chemistry, 401(6-7), pp. 663-676. De Gruyter 10.1515/hsz-2019-0444
The evolution of mitochondrial protein import and the systems that mediate it marks the boundary between the endosymbiotic ancestor of mitochondria and a true organelle that is under the control of the nucleus. Protein import has been studied in grea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114f4d3178b34f7c8aa8f1d7ddd759e4
https://doi.org/10.1515/hsz-2019-0444
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Msp1 cooperates with the proteasome for extraction of arrested mitochondrial import intermediates
Autor: Nikola Wagener, Johannes Wagener, Wasim Aftab, Axel Imhof, Andres Carbonell, Marion Basch, Mirjam Wagner, Rachel Zeng, Stéphane G. Rolland, Siavash Khosravi, Andreas Schmidt, Barbara Conradt
Publikováno v: Molecular Biology of the Cell
The mitochondrial AAA ATPase Msp1 is well known for extraction of mislocalized tail-anchored ER proteins from the mitochondrial outer membrane. Here, we analyzed the extraction of precursors blocking the import pore in the outer membrane. We demonstr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad7dc476157eb9a6cb25c19cd0f954f
https://doi.org/10.1091/mbc.e19-06-0329
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Biogenesis pathways of α-helical mitochondrial outer membrane proteins
Autor: Doron Rapaport, Layla Drwesh
Publikováno v: Biological Chemistry. 401:677-686
Mitochondria harbor in their outer membrane (OM) proteins of different topologies. These proteins are encoded by the nuclear DNA, translated on cytosolic ribosomes and inserted into their target organelle by sophisticated protein import machineries.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fe61830bebc5367f40870074769bc9
https://doi.org/10.1515/hsz-2019-0440
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Mutations in TOMM70 lead to multi-OXPHOS deficiencies and cause severe anemia, lactic acidosis, and developmental delay
Autor: Jianxin Lyu, Jie Xie, Yan Zhou, Miaomiao Du, Hezhi Fang, Pu Xu, Xiujuan Wei, Kun Zhang, Jin Li, Yanling Yang, Manli Jia, Huaibin Zhou, Ting Luo, Deyu Chen
Publikováno v: Journal of Human Genetics. 65:231-240
TOM70 is a member of the TOM complex that transports cytosolic proteins into mitochondria. Here, we identified two compound heterozygous variants in TOMM70 [c.794C>T (p.T265M) and c.1745C>T (p.A582V)] from a patient with severe anemia, lactic acidosi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c31ad15be890a5cbe7d843b9137c8b1c
https://doi.org/10.1038/s10038-019-0714-1
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Tom70-based transcriptional regulation of mitochondrial biogenesis and aging
Autor: B. Fong, Q. Liu, A. C. Wooldredge, B. K. Kennedy, C. E. Chang, Chuankai Zhou
Mitochondrial biogenesis has two major steps: the transcriptional activation of nuclear genome-encoded mitochondrial proteins and the import of nascent mitochondrial proteins that are synthesized in the cytosol. These nascent mitochondrial proteins a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::add11abfacdb6450889c7438f6e30688
https://doi.org/10.1101/2021.11.23.469672
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Monitoring checkpoints of metabolism and protein biogenesis in mitochondria by Phos-tag technology
Autor: Adinarayana Marada, Corvin Walter, Chris Meisinger
Publikováno v: Journal of proteomics. 252
A role for reversible phosphorylation in regulation of mitochondrial proteins has been neglected for a long time. Particularly, the import machineries that mediate influx of more than 1000 different precursor proteins into the organelle were consider
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539fccd448d7c0273ac49729833143a5
https://pubmed.ncbi.nlm.nih.gov/34813945
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10
Role of the Mitochondrial Protein Import Machinery and Protein Processing in Heart Disease
Autor: Ming-Hui Zou, Fujie Zhao
Publikováno v: Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Frontiers in Cardiovascular Medicine
Mitochondria are essential organelles for cellular energy production, metabolic homeostasis, calcium homeostasis, cell proliferation, and apoptosis. About 99% of mammalian mitochondrial proteins are encoded by the nuclear genome, synthesized as precu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f593198f635292568d78c437b914606d
https://www.frontiersin.org/articles/10.3389/fcvm.2021.749756/full
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