Výsledky vyhledávání - "TIC, total ion current"

Data parsing in mass spectrometry imaging using R Studio and Cardinal: A tutorial

Autor: Cameron Shedlock, Katherine Stumpo

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 23, Iss, Pp 58-70 (2022)
Journal of Mass Spectrometry and Advances in the Clinical Lab

Mass spectrometry imaging (MSI) has emerged as a rapidly expanding field in the MS community. The analysis of large spectral data is further complicated by the added spatial dimension of MSI. A plethora of resources exist for expert users to begin pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd723e80de2b52fdcd62794c13682312
https://doi.org/10.1016/j.jmsacl.2021.12.007

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In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging

Autor: Zhonghua Wang, Zeper Abliz, Meiling Huo, Chunyan Yang, Bingshu He, Wenqing Fu, Yaqi Liu, Jinfeng Wei

Publikováno v: Acta Pharmaceutica Sinica B, Vol 10, Iss 6, Pp 1083-1093 (2020)
Acta Pharmaceutica Sinica. B

Understanding of the nephrotoxicity induced by drug candidates is vital to drug discovery and development. Herein, an in situ metabolomics method based on air flow-assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI) wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e79605efb06e65af3a2ee9300ab4fcf
http://www.sciencedirect.com/science/article/pii/S2211383519310718

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Molecular & Cellular Proteomics

Autor: James E. Goldman, Alice Tang, Michelle L. Olsen, Natasha L. Pacheco, Jiangtao Li, Daniel Flint, Brett S. Phinney, Anthony W. Herren, Fatima Khan, Michael R. Heaven

Publikováno v: Molecular & cellular proteomics : MCP, vol 21, iss 1
Molecular & Cellular Proteomics : MCP

Alexander disease (AxD) is a rare and fatal neurodegenerative disorder caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). In this report, a mouse model of AxD (GFAPTg;Gfap+/R236H) was analyzed that contains a heterozygou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27db73f1a1ae5cb5705d0a860adbda89
https://hdl.handle.net/10919/111277

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Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms

Autor: Freek J. Vonk, Govert W. Somsen, Nicholas R. Casewell, Julien Slagboom, Jeroen Kool, Laura-Oana Albulescu, Chunfang Xie

Publikováno v: Acta Pharmaceutica Sinica B, 10(10), 1835-1845. Elsevier BV
Acta Pharmaceutica Sinica. B
Xie, C, Slagboom, J, Albulescu, L O, Somsen, G W, Vonk, F J, Casewell, N R & Kool, J 2020, ' Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms ', Acta Pharmaceutica Sinica B, vol. 10, no. 10, pp. 1835-1845 . https://doi.org/10.1016/j.apsb.2020.09.005
Acta Pharmaceutica Sinica B, Vol 10, Iss 10, Pp 1835-1845 (2020)

Repurposing small molecule drugs and drug candidates is considered as a promising approach to revolutionise the treatment of snakebite envenoming. In this study, we investigated the inhibiting effects of the small molecules varespladib (nonspecific p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1497cb67f49ee39b4203b8d147d304cb

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Characterization of glycan substrates accumulating in GM1 Gangliosidosis

Autor: Brett E. Crawford, Adam Harris, Jeremy L. Van Vleet, Roberto Giugliani, Sanjay Chandriani, Roger Lawrence, Gouri Yogalingam, Linley Mangini, Nathan T. Martin, Wyatt T. Clark, Alessandra d'Azzo, Jonathan H. LeBowitz

Publikováno v: Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports, Vol 21, Iss, Pp-(2019)

Introduction: GM1 gangliosidosis is a rare autosomal recessive genetic disorder caused by the disruption of the GLB1 gene that encodes β-galactosidase, a lysosomal hydrolase that removes β-linked galactose from the non-reducing end of glycans. Defi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad1e65eec41e62a514a14a12ceec192

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AlphaTims: Indexing Trapped Ion Mobility Spectrometry–TOF Data for Fast and Easy Accession and Visualization

Autor: Sander Willems, Matthias Mann, Patricia Skowronek, Eugenia Voytik, Maximilian T. Strauss

Publikováno v: Molecular & Cellular Proteomics : MCP

High-resolution MS-based proteomics generates large amounts of data, even in the standard LC–tandem MS configuration. Adding an ion mobility dimension vastly increases the acquired data volume, challenging both analytical processing pipelines and e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9129c8bbd80512cbab1fea9c7b29d651
https://doi.org/10.1016/j.mcpro.2021.100149

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A versatile ultra-high performance LC-MS method for lipid profiling

Autor: Oskar L, Knittelfelder, Bernd P, Weberhofer, Thomas O, Eichmann, Sepp D, Kohlwein, Gerald N, Rechberger

Publikováno v: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences

Highlights • UPLC-MSE based method for lipid separation and identification. • The method is suitable for polar and non-polar lipid species. • Excellent separation of lipid species within lipid classes. • Identification of low abundant lipid s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f46938c2d56ecdcc8963b7ecd500c9e
https://pubmed.ncbi.nlm.nih.gov/24548922

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Akademický článek

Bioactivity guided isolation and identification of phenolic compounds from Citrus aurantium L. with anti-colorectal cancer cells activity by UHPLC-Q-TOF/MS.

Autor: Gao L; School of Food Science and Engineering, South China University of Technology, Guangzhou, Guangdong, China., Gou N; School of Food Science and Engineering, South China University of Technology, Guangzhou, Guangdong, China., Amakye WK; School of Food Science and Engineering, South China University of Technology, Guangzhou, Guangdong, China., Wu J; State Key Laboratory for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China., Ren J; School of Food Science and Engineering, South China University of Technology, Guangzhou, Guangdong, China.

Publikováno v: Current research in food science [Curr Res Food Sci] 2022 Nov 17; Vol. 5, pp. 2251-2260. Date of Electronic Publication: 2022 Nov 17 (Print Publication: 2022).

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Akademický článek

Imaging mass spectrometry reveals complex lipid distributions across Staphylococcus aureus biofilm layers.

Autor: Rivera ES; Department of Biochemistry, Vanderbilt University, Nashville, TN, USA.; Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA., Weiss A; Department of Pathology Microbiology and Immunology, Vanderbilt University, Nashville, TN, USA., Migas LG; Delft University of Technology, Delft, Netherlands., Freiberg JA; Department of Pathology Microbiology and Immunology, Vanderbilt University, Nashville, TN, USA., Djambazova KV; Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA.; Department of Chemistry, Vanderbilt University, Nashville, TN, USA., Neumann EK; Department of Biochemistry, Vanderbilt University, Nashville, TN, USA.; Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA., Van de Plas R; Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA.; Delft University of Technology, Delft, Netherlands., Spraggins JM; Department of Biochemistry, Vanderbilt University, Nashville, TN, USA.; Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA.; Department of Chemistry, Vanderbilt University, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Skaar EP; Department of Pathology Microbiology and Immunology, Vanderbilt University, Nashville, TN, USA., Caprioli RM; Department of Biochemistry, Vanderbilt University, Nashville, TN, USA.; Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA.; Department of Chemistry, Vanderbilt University, Nashville, TN, USA.; Department of Medicine, Vanderbilt University, Nashville, TN, USA.; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.

Publikováno v: Journal of mass spectrometry and advances in the clinical lab [J Mass Spectrom Adv Clin Lab] 2022 Sep 13; Vol. 26, pp. 36-46. Date of Electronic Publication: 2022 Sep 13 (Print Publication: 2022).

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Akademický článek

Data parsing in mass spectrometry imaging using R Studio and Cardinal: A tutorial.

Autor: Shedlock CJ; Department of Chemistry, University of Scranton, Scranton, PA 18510, United States., Stumpo KA; Department of Chemistry, University of Scranton, Scranton, PA 18510, United States.; Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.; Bruker Scientific, Billerica, MA 01821, United States.

Publikováno v: Journal of mass spectrometry and advances in the clinical lab [J Mass Spectrom Adv Clin Lab] 2021 Dec 20; Vol. 23, pp. 58-70. Date of Electronic Publication: 2021 Dec 20 (Print Publication: 2022).

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