Tumor-associated macrophages confer resistance to chemotherapy (Trifluridine/Tipiracil) in digestive cancers by overexpressing thymidine phosphorylase.

Autor: Malier M; Univ.Grenoble Alpes, Inserm U1209, CNRS UMR5309, Institute for Advanced Biosciences, Team Mechanobiology, Immunity and Cancer, 38000, Grenoble, France., Laverriere MH; Univ.Grenoble Alpes, Inserm U1209, CNRS UMR5309, Institute for Advanced Biosciences, Team Mechanobiology, Immunity and Cancer, 38000, Grenoble, France; Department of Pathology, DACP, University Hospital, Grenoble, France., Henry M; Univ.Grenoble Alpes, Inserm U1209, CNRS UMR5309, Institute for Advanced Biosciences OPTIMAL platform, Grenoble, France., Yakoubi M; CRCT Inserm U037, Toulouse University 3, Toulouse, France., Bellaud P; Univ Rennes, CNRS, Inserm, Biosit UAR 3480 US_S 018, France-BioImaging (ANR-10-INBS-04), Core Facility H2P2, F-35000, Rennes, France., Arellano C; CRCT Inserm U037, Toulouse University 3, Toulouse, France., Sébillot A; Univ Rennes, CNRS, Inserm, Biosit UAR 3480 US_S 018, France-BioImaging (ANR-10-INBS-04), Core Facility H2P2, F-35000, Rennes, France., Thomas F; CRCT Inserm U037, Toulouse University 3, Toulouse, France., Josserand V; Univ.Grenoble Alpes, Inserm U1209, CNRS UMR5309, Institute for Advanced Biosciences OPTIMAL platform, Grenoble, France., Girard E; Univ.Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, CHU Grenoble Alpes, TIMC, 38000, Grenoble, France., Roth GS; Univ.Grenoble Alpes, Inserm U1209, CNRS UMR5309, Institute for Advanced Biosciences, Team Mechanobiology, Immunity and Cancer, 38000, Grenoble, France; Hepato-Gastroenterology and Digestive Oncology department, University Hospital, Grenoble, France., Millet A; Univ.Grenoble Alpes, Inserm U1209, CNRS UMR5309, Institute for Advanced Biosciences, Team Mechanobiology, Immunity and Cancer, 38000, Grenoble, France; Hepato-Gastroenterology and Digestive Oncology department, University Hospital, Grenoble, France. Electronic address: arnaud.millet@inserm.fr.

Publikováno v: Cancer letters [Cancer Lett] 2024 Dec 01; Vol. 606, pp. 217307. Date of Electronic Publication: 2024 Oct 23.

Thymidine Phosphorylase Imaging Probe for Differential Diagnosis of Metabolic dysfunction-associated Steatohepatitis.

Autor: Higashikawa K; Central Institute of Isotope Science, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-0815, Japan., Uehara R; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan., Horiguchi S; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan., Shibata Y; Central Institute of Isotope Science, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-0815, Japan.; Graduate School of Biomedical Science and Engineering, Hokkaido University, Sapporo, 060-0815, Japan.; Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan., Okubo N; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan., Mizuno Y; Central Institute of Isotope Science, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-0815, Japan.; Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo, 060-0815, Japan., Yasui H; Central Institute of Isotope Science, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-0815, Japan.; Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan., Ohnishi S; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan., Takeda H; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan., Kuge Y; Central Institute of Isotope Science, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-0815, Japan. kuge@ric.hokudai.ac.jp.; Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo, 060-0815, Japan. kuge@ric.hokudai.ac.jp.

Publikováno v: Molecular imaging and biology [Mol Imaging Biol] 2024 Dec; Vol. 26 (6), pp. 1036-1045. Date of Electronic Publication: 2024 Nov 13.

Facile benzothiazole-triazole based thiazole derivatives as novel thymidine phosphorylase and α-glucosidase inhibitors: Experimental and computational approaches.

Autor: Khan S; Department of Chemistry, Abbottabad University of Science and Technology (AUST), Abbottabad 22500, Pakistan. Electronic address: shoaibkhanswati@gmail.com., Hussain R; Department of Chemistry, Hazara University, Mansehra 21120, Pakistan. Electronic address: rafaqathussain0347@gmail.com., Khan Y; Department of Chemistry, COMSATS University Islamabad campus, Islamabad 45550, Pakistan., Iqbal T; Department of Chemistry, Abbottabad University of Science and Technology (AUST), Abbottabad 22500, Pakistan., Ullah F; Department of Chemistry, Abbottabad University of Science and Technology (AUST), Abbottabad 22500, Pakistan., Felemban S; Department of Chemistry, Faculty of Applied Science, University College-Al Leith, University of Umm Al-Qura, Makkah 21955, Saudi Arabia., Khowdiary MM; Department of Chemistry, Faculty of Applied Science, University College-Al Leith, University of Umm Al-Qura, Makkah 21955, Saudi Arabia.

Publikováno v: Enzyme and microbial technology [Enzyme Microb Technol] 2024 Sep; Vol. 179, pp. 110470. Date of Electronic Publication: 2024 Jun 13.

Lysosomal dysfunction and overload of nucleosides in thymidine phosphorylase deficiency of MNGIE.

Autor: Du J; Department of Rheumatology and Immunology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Research Institute of Neuromuscular and Neurodegenerative Disease, Department of Neurology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, West Wenhua Street No.107, Jinan, 250012, Shandong, China.; Department of Rheumatology and Immunology, Cheeloo College of Medicine, Shandong Provincial Hospital, Shandong University, Jinan, 250021, Shandong, China., Liu F; Research Institute of Neuromuscular and Neurodegenerative Disease, Department of Neurology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, West Wenhua Street No.107, Jinan, 250012, Shandong, China., Liu X; Key Laboratory of Experimental Teratology, Ministry of Education, School of Basic Medical Science, Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China., Zhao D; Research Institute of Neuromuscular and Neurodegenerative Disease, Department of Neurology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, West Wenhua Street No.107, Jinan, 250012, Shandong, China., Wang D; Research Institute of Neuromuscular and Neurodegenerative Disease, Department of Neurology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, West Wenhua Street No.107, Jinan, 250012, Shandong, China., Sun H; Department of Rheumatology and Immunology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Department of Rheumatology and Immunology, Cheeloo College of Medicine, Shandong Provincial Hospital, Shandong University, Jinan, 250021, Shandong, China., Yan C; Research Institute of Neuromuscular and Neurodegenerative Disease, Department of Neurology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, West Wenhua Street No.107, Jinan, 250012, Shandong, China. czyan@sdu.edu.cn.; Mitochondrial Medicine Laboratory, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, 266000, Shandong, China. czyan@sdu.edu.cn.; Brain Science Research Institute, Shandong University, Jinan, 250012, Shandong, China. czyan@sdu.edu.cn., Zhao Y; Research Institute of Neuromuscular and Neurodegenerative Disease, Department of Neurology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, West Wenhua Street No.107, Jinan, 250012, Shandong, China. zyy72@126.com.

Publikováno v: Journal of translational medicine [J Transl Med] 2024 May 13; Vol. 22 (1), pp. 449. Date of Electronic Publication: 2024 May 13.

Proteomic profiling of gliomas unveils immune and metabolism-driven subtypes with implications for anti-nucleotide metabolism therapy.

Autor: Zhang J; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Shanghai, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China., Sun R; Affiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, Westlake University, Hangzhou, Zhejiang, China.; Westlake Center for Intelligent Proteomics, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.; Research Center for Industries of the Future, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Lyu Y; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Shanghai, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China., Liu C; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Shanghai, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China., Liu Y; Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China., Feng Y; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Shanghai, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China., Fu M; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Shanghai, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China., Wong PJC; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Shanghai, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China., Du Z; Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China., Qiu T; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Shanghai, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China., Zhang Y; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Shanghai, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China., Zhuang D; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Shanghai, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China., Qin Z; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Shanghai, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China., Yao Y; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Shanghai, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China., Zhu W; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Shanghai, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China.; Neurosurgical Institute of Fudan University, Shanghai, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China., Guo T; Affiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, Westlake University, Hangzhou, Zhejiang, China.; Westlake Center for Intelligent Proteomics, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.; Research Center for Industries of the Future, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Hua W; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China. hs_huawei@126.com.; National Center for Neurological Disorders, Shanghai, China. hs_huawei@126.com.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China. hs_huawei@126.com.; Neurosurgical Institute of Fudan University, Shanghai, China. hs_huawei@126.com.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China. hs_huawei@126.com., Yang H; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China. hui_yang@fudan.edu.cn.; National Center for Neurological Disorders, Shanghai, China. hui_yang@fudan.edu.cn.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China. hui_yang@fudan.edu.cn.; Neurosurgical Institute of Fudan University, Shanghai, China. hui_yang@fudan.edu.cn.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China. hui_yang@fudan.edu.cn.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institute for Translational Brain Research, Shanghai Medical College, Fudan University, Shanghai, China. hui_yang@fudan.edu.cn., Mao Y; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China. maoying@fudan.edu.cn.; National Center for Neurological Disorders, Shanghai, China. maoying@fudan.edu.cn.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China. maoying@fudan.edu.cn.; Neurosurgical Institute of Fudan University, Shanghai, China. maoying@fudan.edu.cn.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China. maoying@fudan.edu.cn.

Publikováno v: Nature communications [Nat Commun] 2024 Nov 19; Vol. 15 (1), pp. 10005. Date of Electronic Publication: 2024 Nov 19.