Zobrazeno 1 - 10
of 132
pro vyhledávání: '"THU H. LE"'
Autor:
Maliha Ahmed, Tanzy Love, Catherine Moore, Thu H. Le, Jerome Jean-Gilles, Bruce Goldman, Hae Yoon Grace Choung
Publikováno v:
Renal Failure, Vol 44, Iss 1, Pp 581-593 (2022)
Background A subset of patients without overt systemic lupus erythematosus (SLE) present with biopsy findings typically seen in lupus nephritis (LN). Although a minority eventually develops SLE, many do not. It remains unclear how to classify or trea
Externí odkaz:
https://doaj.org/article/86ef3827f0bc467fb05cff77f951fd60
Autor:
Andrew P. Morris, Thu H. Le, Haojia Wu, Artur Akbarov, Peter J. van der Most, Gibran Hemani, George Davey Smith, Anubha Mahajan, Kyle J. Gaulton, Girish N. Nadkarni, Adan Valladares-Salgado, Niels Wacher-Rodarte, Josyf C. Mychaleckyj, Nicole D. Dueker, Xiuqing Guo, Yang Hai, Jeffrey Haessler, Yoichiro Kamatani, Adrienne M. Stilp, Gu Zhu, James P. Cook, Johan Ärnlöv, Susan H. Blanton, Martin H. de Borst, Erwin P. Bottinger, Thomas A. Buchanan, Sylvia Cechova, Fadi J. Charchar, Pei-Lun Chu, Jeffrey Damman, James Eales, Ali G. Gharavi, Vilmantas Giedraitis, Andrew C. Heath, Eli Ipp, Krzysztof Kiryluk, Holly J. Kramer, Michiaki Kubo, Anders Larsson, Cecilia M. Lindgren, Yingchang Lu, Pamela A. F. Madden, Grant W. Montgomery, George J. Papanicolaou, Leslie J. Raffel, Ralph L. Sacco, Elena Sanchez, Holger Stark, Johan Sundstrom, Kent D. Taylor, Anny H. Xiang, Aleksandra Zivkovic, Lars Lind, Erik Ingelsson, Nicholas G. Martin, John B. Whitfield, Jianwen Cai, Cathy C. Laurie, Yukinori Okada, Koichi Matsuda, Charles Kooperberg, Yii-Der Ida Chen, Tatjana Rundek, Stephen S. Rich, Ruth J. F. Loos, Esteban J. Parra, Miguel Cruz, Jerome I. Rotter, Harold Snieder, Maciej Tomaszewski, Benjamin D. Humphreys, Nora Franceschini
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Estimated glomerular filtration rate (eGFR) is a measure of kidney function used to define chronic kidney disease. Here, Morris et al. perform trans-ethnic genome-wide meta-analyses for eGFR in 312,468 individuals and identify novel loci and downstre
Externí odkaz:
https://doaj.org/article/b8a9cf68600449b683542f422dc012d2
Autor:
Pei-Lun Chu, Joseph C. Gigliotti, Sylvia Cechova, Gabor Bodonyi-Kovacs, Yves T. Wang, Luojing Chen, Sylvia Wassertheil-Smoller, Jianwen Cai, Brant E. Isakson, Nora Franceschini, Thu H. Le
Publikováno v:
American Journal of Physiology-Renal Physiology. 324:F30-F42
The findings of our study are significant in several ways: 1) loss of an amino acid chaperone in the proximal tubule is sufficient to cause hypertension, 2) the results in global and proximal tubule-specific collectrin knockout mice support the notio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8916a7e38d01f9f03b405373b05af6d2
https://doi.org/10.1152/ajprenal.00176.2022
https://doi.org/10.1152/ajprenal.00176.2022
Publikováno v:
Kidney360. 4:245-257
Extracellular vesicles (EVs) are evolving as novel cell mediators, biomarkers, and therapeutic targets in kidney health and disease. They are naturally derived from cells both within and outside the kidney and carry cargo which mirrors the state of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d751b88dddd8f8a23948f2b44e431e41
https://doi.org/10.34067/kid.0001892022
https://doi.org/10.34067/kid.0001892022
Autor:
Rickinder Grewal, Hae Yoon G. Choung, Lisa L. Roberts, Timothy Beane, Luojing Chen, Daniel X. Gilroy, Phillip M. Rappold, Thu H. Le
Publikováno v:
Acta Oncologica. 61:1507-1511
Transmembrane protein 27 (TMEM27/collectrin), a glycoprotein and homolog of angiotensin-converting enzyme 2 (ACE2), is a regulator of renal amino acid uptake in the proximal tubule and may have a protective role in hypertension. Two previous reports
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb3f64e1927a8aafe1334ab8c24e9ac
https://doi.org/10.1080/0284186x.2022.2143279
https://doi.org/10.1080/0284186x.2022.2143279
Autor:
Rebecca V. Levy, Kimberly J. Reidy, Thu H. Le, Victor David, Cheryl Winkler, Yunwen Xu, Bradley Warady, Susan Furth, Frederick Kaskel, Michal L. Melamed
Publikováno v:
Am J Kidney Dis
RATIONALE & OBJECTIVE: Loss of function of the product of the GSTM1 gene has been implicated in rapid progression of adult chronic kidney disease (CKD). Its role in pediatric CKD has not been previously described. STUDY DESIGN: Secondary analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4d636721774820c12208e632a0551b
https://doi.org/10.1053/j.ajkd.2021.10.007
https://doi.org/10.1053/j.ajkd.2021.10.007
Autor:
Nora Franceschini, Thu H. Le
Publikováno v:
J Am Soc Nephrol
BACKGROUND: Uromodulin, the most abundant protein excreted in normal urine, plays major roles in kidney physiology and disease. The mechanisms regulating the urinary excretion of uromodulin remain essentially unknown. METHODS: We conducted a meta-ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c9b485e6fa03402f099925c835e445
https://pubmed.ncbi.nlm.nih.gov/35228297
https://pubmed.ncbi.nlm.nih.gov/35228297
Autor:
Hae Yoon Grace Choung, Catherine Moore, Thu H. Le, Paul Guirguis, Jack M McKeown, Jerome Jean-Gilles, Bruce Goldman
Publikováno v:
Nephron.
Introduction: The pathologic features of membranous lupus nephritis (MLN) are occasionally encountered in secondary membranous nephropathy (sMN) without overt clinical evidence of SLE. Moreover, some sMN with lupus-like features (LL-MN) have a clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd7aa525d23fbe06a9e273b92fe8214f
https://doi.org/10.1159/000529437
https://doi.org/10.1159/000529437
Autor:
Pei-Lun, Chu, Joseph C, Gigliotti, Sylvia, Cechova, Gabor, Bodonyi-Kovacs, Yves T, Wang, Luojing, Chen, Sylvia, Wassertheil-Smoller, Jianwen, Cai, Brant E, Isakson, Nora, Franceschini, Thu H, Le
Publikováno v:
American journal of physiology. Renal physiology. 324(1)
Collectrin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::018f2d8ddd6d9d2fbf9b241e033a6e4f
https://pubmed.ncbi.nlm.nih.gov/36264884
https://pubmed.ncbi.nlm.nih.gov/36264884
Autor:
Rebecca Levy, Thu H. Le
Publikováno v:
Kidney360
Over 20 years after the introduction of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, CKD remains a major public health burden with limited therapeutic options to halt or slow kidney disease progression at all ages. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03567cb2fb5dbf1463c5f005741bf29
https://europepmc.org/articles/PMC9802555/
https://europepmc.org/articles/PMC9802555/
