Zobrazeno 1 - 10
of 175 479
pro vyhledávání: '"THOMAS R"'
Autor:
Muhamad Hartono, Andrew G. Baker, Thomas R. Else, Alexander S. Evtushenko, Sarah E. Bohndiek, Daniel Muñoz-Espín, Ljiljana Fruk
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Cellular senescence is considered an important tumour suppression mechanism in response to damage and oncogenic stress in early lesions. However, when senescent cells are not immune-cleared and persist in the tumour microenvironment, they ca
Externí odkaz:
https://doaj.org/article/bd57bc3ca13641928303ebf958e5d0e1
Autor:
Maria Gonzalez-Orozco, Hsiang-chi Tseng, Adam Hage, Hongjie Xia, Padmanava Behera, Kazi Afreen, Yoatzin Peñaflor-Tellez, Maria I. Giraldo, Matthew Huante, Lucinda Puebla-Clark, Sarah van Tol, Abby Odle, Matthew Crown, Natalia Teruel, Thomas R. Shelite, Joaquin Moreno-Contreras, Kaori Terasaki, Shinji Makino, Vineet Menachery, Mark Endsley, Janice J. Endsley, Rafael J. Najmanovich, Matthew Bashton, Robin Stephens, Pei-Yong Shi, Xuping Xie, Alexander N. Freiberg, Ricardo Rajsbaum
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract SARS-CoV-2 is a highly transmissible virus that causes COVID-19 disease. Mechanisms of viral pathogenesis include excessive inflammation and viral-induced cell death, resulting in tissue damage. Here we show that the host E3-ubiquitin ligase
Externí odkaz:
https://doaj.org/article/95c2025727034eb3ac04a9a6c6cbb887
Autor:
Behrang Fazli Besheli, Zhiyi Sha, Jay R. Gavvala, Sacit Karamursel, Michael Quach, Chandra Prakash Swamy, Amir Hossein Ayyoubi, Alica M. Goldman, Daniel J. Curry, Sameer A. Sheth, David Darrow, Kai J. Miller, David J. Francis, Gregory A. Worrell, Thomas R. Henry, Nuri F. Ince
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-13 (2024)
Abstract Background While high-frequency oscillations (HFOs) and their stereotyped clusters (sHFOs) have emerged as potential neuro-biomarkers for the rapid localization of the seizure onset zone (SOZ) in epilepsy, their clinical application is hinde
Externí odkaz:
https://doaj.org/article/16c3218c17fe4a649cb29fcf7612d65c
Publikováno v:
BioMedical Engineering OnLine, Vol 23, Iss 1, Pp 1-23 (2024)
Abstract Background Extracellular vesicles (EVs) have emerged as an exciting tool for targeted delivery of therapeutics for a wide range of diseases. As nano-scale membrane-bound particles derived from living cells, EVs possess inherent capabilities
Externí odkaz:
https://doaj.org/article/6c79735bf1b549dba28636b9ab6e274a
Autor:
Barış Yaşar, Nina Boskovic, Marilin Ivask, Jere Weltner, Eeva-Mari Jouhilahti, Piibe Vill, Tiina Skoog, Ülle Jaakma, Juha Kere, Thomas R. Bürglin, Shintaro Katayama, Tõnis Org, Ants Kurg
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Embryonic genome activation (EGA) is a critical step in early embryonic development, as it marks the transition from relying on maternal factors to the initiation of transcription from embryo’s own genome. The factors associated
Externí odkaz:
https://doaj.org/article/cd92ba7b704641dd8d6998ca2c0bee40
Autor:
Juliano Tiburcio de Freitas, Varsha Thakur, Kathryn M. LaPorte, Vijay S. Thakur, Brian Flores, Valentina Caicedo, Chioma G. E. Ajaegbu, Giuseppe Ingrasci, Zoe M. Lipman, Keman Zhang, Hong Qiu, Thomas R. Malek, Barbara Bedogni
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-14 (2024)
Abstract Background Immune checkpoint inhibitors (ICI) have dramatically improved the life expectancy of patients with metastatic melanoma. However, about half of the patient population still present resistance to these treatments. We have previously
Externí odkaz:
https://doaj.org/article/02f457d9d27b4896be22ab657b8b7584
Autor:
David Gonzalez-Martinez, Lee Roth, Thomas R. Mumford, Juan Guan, Anh Le, Robert C. Doebele, Bo Huang, Asmin Tulpule, Magdalena Niewiadomska-Bugaj, Trever G. Bivona, Lukasz J. Bugaj
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Drug resistance remains a challenge for targeted therapy of cancers driven by EML4-ALK and related fusion oncogenes. EML4-ALK forms cytoplasmic protein condensates, which result from networks of interactions between oncogene and adapter prot
Externí odkaz:
https://doaj.org/article/369d4a9ed829495a9689692c1e1918f3
Autor:
Noah H. Reed, Thomas R. Butts, Jason K. Norsworthy, Jarrod T. Hardke, L. Tom Barber, Jason A. Bond, Hunter D. Bowman, Nick R. Bateman, Aurelie M. Poncet, Koffi B. J. Kouame
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Rice (Oryza sativa L.) producers in the Mid-south are experiencing difficulties with herbicide-resistant weeds such as barnyardgrass [Echinochloa crus-galli (L.) P. Beauv.]. As a result, methods that can alter E. crus-galli ecology are neede
Externí odkaz:
https://doaj.org/article/3446dabf5d9342fb9e4d832c5556724c
Autor:
Tetsu Anan, Roberto Casini, Han Uitenbroek, Thomas A. Schad, Hector Socas-Navarro, Kiyoshi Ichimoto, Sarah A. Jaeggli, Sanjiv K. Tiwari, Jeffrey W. Reep, Yukio Katsukawa, Ayumi Asai, Jiong Qiu, Kevin P. Reardon, Alexandra Tritschler, Friedrich Wöger, Thomas R. Rimmele
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract The efficient release of magnetic energy in astrophysical plasmas, such as during solar flares, can in principle be achieved through magnetic diffusion, at a rate determined by the associated electric field. However, attempts at measuring el
Externí odkaz:
https://doaj.org/article/1c1ccbb820d44227aa9c3624f67db35a
Autor:
Junhao Wen, Zhijian Yang, Ilya M. Nasrallah, Yuhan Cui, Guray Erus, Dhivya Srinivasan, Ahmed Abdulkadir, Elizabeth Mamourian, Gyujoon Hwang, Ashish Singh, Mark Bergman, Jingxuan Bao, Erdem Varol, Zhen Zhou, Aleix Boquet-Pujadas, Jiong Chen, Arthur W. Toga, Andrew J. Saykin, Timothy J. Hohman, Paul M. Thompson, Sylvia Villeneuve, Randy Gollub, Aristeidis Sotiras, Katharina Wittfeld, Hans J. Grabe, Duygu Tosun, Murat Bilgel, Yang An, Daniel S. Marcus, Pamela LaMontagne, Tammie L. Benzinger, Susan R. Heckbert, Thomas R. Austin, Lenore J. Launer, Mark Espeland, Colin L. Masters, Paul Maruff, Jurgen Fripp, Sterling C. Johnson, John C. Morris, Marilyn S. Albert, R. Nick Bryan, Susan M. Resnick, Luigi Ferrucci, Yong Fan, Mohamad Habes, David Wolk, Li Shen, Haochang Shou, Christos Davatzikos
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Alzheimer’s disease (AD) is associated with heterogeneous atrophy patterns. We employed a semi-supervised representation learning technique known as Surreal-GAN, through which we identified two latent dimensional representations of brain a
Externí odkaz:
https://doaj.org/article/56d631e8319148739bce0f8e8b35d005