Zobrazeno 1 - 10
of 385
pro vyhledávání: '"THOMAS N. WIGHT"'
Autor:
Hunter A. Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K. Reid, Nadine Nagy, Graham Barlow, Ben A. Falk, Carlos O. Medina, Aviv Hargil, Svenja Zihsler, Israel Vlodavsky, Jin-Ping Li, Magdiel Pérez-Cruz, Sai-Wen Tang, Everett H. Meyer, Lucile E. Wrenshall, James D. Lord, K. Christopher Garcia, Theo D. Palmer, Lawrence Steinman, Gerald T. Nepom, Thomas N. Wight, Paul L. Bollyky, Hedwich F. Kuipers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Although FOXP3+ regulatory T cells (Treg) depend on IL-2 produced by other cells for their survival and function, the levels of IL-2 in inflamed tissue are low, making it unclear how Treg access this critical resource. Here, we show that Tre
Externí odkaz:
https://doaj.org/article/378775d4b0fd41108905367cda2de0de
Autor:
Nadine Nagy, Kathryn S. Czepiel, Gernot Kaber, Darko Stefanovski, Aviv Hargil, Nina Pennetzdorfer, Robert Targ, Saranya C. Reghupaty, Thomas N. Wight, Robert B. Vernon, Rebecca L. Hull-Meichle, Payton Marshall, Carlos O. Medina, Hunter Martinez, Anissa Kalinowski, Rudolph D. Paladini, Stavros Garantziotis, Joshua W. Knowles, Paul L. Bollyky
Publikováno v:
Cells, Vol 13, Iss 20, p 1727 (2024)
Given that the extracellular matrix polymer hyaluronan (HA) has been implicated in longevity, we asked whether 4-methylumbelliferone (4-MU), an inhibitor of HA synthesis, impacts lifespan in mice. We designed a prospective study of long-term administ
Externí odkaz:
https://doaj.org/article/da7d8866843c4dd994d1c93481a81662
Autor:
Samira Ghorbani, Emily Jelinek, Rajiv Jain, Benjamin Buehner, Cenxiao Li, Brian M. Lozinski, Susobhan Sarkar, Deepak K. Kaushik, Yifei Dong, Thomas N. Wight, Soheila Karimi-Abdolrezaee, Geert J. Schenk, Eva M. Strijbis, Jeroen Geurts, Ping Zhang, Chang-Chun Ling, V. Wee Yong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Ghorbani and colleagues describe versican-V1 as an inhibitor of remyelination using transgenic mice that illuminate new GFP + oligodendrocytes. Mechanisms of versican-V1 include the direct inhibition of oligodendrocytes, and elevating Th17 cells.
Externí odkaz:
https://doaj.org/article/0c313dc1a017483292124286d17323a9
Autor:
Michael J. Kratochvil, Gernot Kaber, Sally Demirdjian, Pamela C. Cai, Elizabeth B. Burgener, Nadine Nagy, Graham L. Barlow, Medeea Popescu, Mark R. Nicolls, Michael G. Ozawa, Donald P. Regula, Ana E. Pacheco-Navarro, Samuel Yang, Vinicio A. de Jesus Perez, Harry Karmouty-Quintana, Andrew M. Peters, Bihong Zhao, Maximilian L. Buja, Pamela Y. Johnson, Robert B. Vernon, Thomas N. Wight, Stanford COVID-19 Biobank Study Group, Carlos E. Milla, Angela J. Rogers, Andrew J. Spakowitz, Sarah C. Heilshorn, Paul L. Bollyky
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Thick, viscous respiratory secretions are a major pathogenic feature of COVID-19, but the composition and physical properties of these secretions are poorly understood. We characterized the composition and rheological properties (i.e., resistance to
Externí odkaz:
https://doaj.org/article/5333021197714d0f86602625ced4f91f
Autor:
Inkyung Kang, Christian Hundhausen, Stephen P. Evanko, Prasanthi Malapati, Gail Workman, Christina K. Chan, Cliff Rims, Gary S. Firestein, David L. Boyle, Kevin M. MacDonald, Jane H. Buckner, Thomas N. Wight
Publikováno v:
Matrix Biology Plus, Vol 14, Iss , Pp 100110- (2022)
The content and organization of hyaluronan (HA) in the extracellular matrix (ECM) have been identified as strong indicators of inflammation in joint disease, although the source and role of HA as an effector of inflammation is not clear. In this stud
Externí odkaz:
https://doaj.org/article/672816b90c5e42e8b85dff5cd6de79d6
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
A growing body of literature links events associated with the progression and severity of immunity and inflammatory disease with the composition of the tissue extracellular matrix as defined by the matrisome. One protein in the matrisome that is comm
Externí odkaz:
https://doaj.org/article/dfb20fa42a6c49bba00cd2535b729103
Autor:
John A. Gebe, Michel D. Gooden, Gail Workman, Nadine Nagy, Paul L. Bollyky, Thomas N. Wight, Robert B. Vernon
Publikováno v:
Matrix Biology Plus, Vol 9, Iss , Pp 100052- (2021)
The extracellular matrix glycosaminoglycan hyaluronan (HA) accumulates in human and mouse islets during the onset of autoimmune type 1 diabetes (T1D). HA plays a critical role in T1D pathogenesis, as spontaneous disease is blocked in mice fed the HA
Externí odkaz:
https://doaj.org/article/f80433efdfa743f1815450736b8a1bf5
Autor:
Chang Yeop Han, Inkyung Kang, Mohamed Omer, Shari Wang, Tomasz Wietecha, Thomas N. Wight, Alan Chait
Publikováno v:
JCI Insight, Vol 5, Iss 20 (2020)
The ability of HDL to inhibit inflammation in adipocytes and adipose tissue is reduced when HDL contains serum amyloid A (SAA) that is trapped by proteoglycans at the adipocyte surface. Because we recently found that the major extracellular matrix pr
Externí odkaz:
https://doaj.org/article/9756de8f826141f399d2f719eaee6049
Autor:
Chang Yeop Han, Inkyung Kang, Ingrid A. Harten, John A. Gebe, Christina K. Chan, Mohamed Omer, Kimberly M. Alonge, Laura J. den Hartigh, Diego Gomes Kjerulf, Leela Goodspeed, Savitha Subramanian, Shari Wang, Francis Kim, David E. Birk, Thomas N. Wight, Alan Chait
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107818- (2020)
Summary: Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their role in adipose tissue inflammation in obesity. We find that adipose tissue versican and biglycan increase in obe
Externí odkaz:
https://doaj.org/article/0ab5266a0eec4194a0bd5b3e2ad576af
Autor:
Thomas N. Wight, Inkyung Kang, Stephen P. Evanko, Ingrid A. Harten, Mary Y. Chang, Oliver M. T. Pearce, Carys E. Allen, Charles W. Frevert
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM versican binding molecules such as hyaluronan, tumor necrosis factor stimulated gene-6 (TSG-6), and inter alpha trypsin inhibitor (IαI) during inflammation in a num
Externí odkaz:
https://doaj.org/article/b4f9bdd001fd495a8cc95582e45802de